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NTR: add sympathoblast (CL_9900001) #3810

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NTR: add sympathoblast (CL_9900001) #3810

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NTR: add sympathoblast (CL_9900001)
github-actions[bot] Oct 16, 2026
fed37b0
Amend sympathoblast definition and references (#3809)
github-actions[bot] Oct 19, 2026
1383746
Add molecular markers comment for sympathoblast (#3809)
claude[bot] Oct 19, 2026
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14 changes: 14 additions & 0 deletions src/ontology/cl-edit.owl
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Original file line number Diff line number Diff line change
Expand Up @@ -3370,6 +3370,7 @@ Declaration(Class(obo:CL_7770003))
Declaration(Class(obo:CL_7770004))
Declaration(Class(obo:CL_7770005))
Declaration(Class(obo:CL_7770006))
Declaration(Class(obo:CL_9900001))
Declaration(Class(obo:CP_0000000))
Declaration(Class(obo:CP_0000025))
Declaration(Class(obo:CP_0000027))
Expand Down Expand Up @@ -36585,6 +36586,19 @@ SubClassOf(obo:CL_7770006 obo:CL_0002367)
SubClassOf(obo:CL_7770006 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606))
SubClassOf(obo:CL_7770006 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_Q9UIK5))

# Class: obo:CL_9900001 (sympathoblast)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33833454") Annotation(oboInOwl:hasDbXref "PMID:35277192") Annotation(oboInOwl:hasDbXref "PMID:37361539") Annotation(oboInOwl:hasDbXref "PMID:38632395") obo:IAO_0000115 obo:CL_9900001 "A proliferating, immature cell of the sympathoadrenal lineage, derived from the neural crest. Sympathoblasts are found in both intra-adrenal (within the adrenal medulla) and extra-adrenal (such as sympathetic ganglia) locations during embryonic development, and are a key intermediate in the developmental pathway from neural crest cells to postganglionic sympathetic neurons and chromaffin cells.")
AnnotationAssertion(terms:creator obo:CL_9900001 "Claude")
AnnotationAssertion(terms:date obo:CL_9900001 "2026-10-16T15:51:18Z"^^xsd:dateTime)
AnnotationAssertion(obo:IAO_0000233 obo:CL_9900001 "https://github.com/obophenotype/cell-ontology/issues/3809")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:38632395") oboInOwl:hasRelatedSynonym obo:CL_9900001 "sympathetic neuroblast")
AnnotationAssertion(rdfs:label obo:CL_9900001 "sympathoblast")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33833454") Annotation(oboInOwl:hasDbXref "PMID:35277192") Annotation(oboInOwl:hasDbXref "PMID:37361539") rdfs:comment obo:CL_9900001 "Commonly cited molecular markers for sympathoblasts include STMN2, ISL1, PRPH, NEFM, GAP43, ALK, and CARTPT. These markers are used to identify sympathoblasts in both developmental biology and neuroblastoma research.")
SubClassOf(obo:CL_9900001 obo:CL_0002676)
SubClassOf(obo:CL_9900001 ObjectSomeValuesFrom(obo:RO_0002203 obo:CL_0000166))
SubClassOf(obo:CL_9900001 ObjectSomeValuesFrom(obo:RO_0002203 obo:CL_0011103))

# Class: obo:CP_0000000 (obsolete CP:0000000)

AnnotationAssertion(obo:IAO_0100001 obo:CP_0000000 obo:CL_0017500)
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