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+SAFETY DATA SHEET
+Creation Date 28-Apr-2009 Revision Date 13-Oct-2023 Revision Number 9
+1. Identification
+Product Name Acetone
+Cat No. : A9-4; A9-20; A9-200; A11-1; A11-4; A11-20; A11-200; A11S-4; A13-20;
+A13-200; A16F-1GAL; A16P-1GAL; A16P-4; A16S-4; A16S-20; A18-1;
+A18-4; A18-20; A18-20LC; A18-200; A18-200LC; A18-500; A18CU1300;
+A18FB-19; A18FB-50; A18FB-115; A18FB-200; A18P-4; A18POP-19;
+A18POPB-50; A18RB-19; A18RB-50; A18RB-115; A18RB-200;
+A18RS-28; A18RS-50; A18RS-115; A18RS-200; A18S-4; A18SK-4;
+A18SS-19; A18SS-28; A18SS-50; A18SS-115; A18SS-200; A19-1;
+A19-4; A19RS-115; A19RS-200; A40-4; A928-4; A929-1; A929-4;
+A929-4LC; A929RS-19; A929RS-50; A929RS-200; A929SK-4;
+A929SS-28; A929SS-50; A929SS-115; A929SS-200; A946-4; A946-4LC;
+A946FB-200; A946RB-19; A946RB-50; A946RB-115; A946RB-200;
+A949-1; A949-4; A949-4LC; A949CU-50; A949N-119; A949N-219;
+A949POP-19; A949RS-28; A949RS-50; A949RS-115; A949SK-1;
+A949SK-4; A949SS-19; A949SS-28; A949SS-50; A949SS-115;
+A949SS-200; BP2403-1; BP2403-4; BP2403-20; BP2403-RS200;
+BP2404-1; BP2404-4; BP2404-SK1; BP2404-SK4; HC300-1GAL;
+S70091; 22050131; 22050295; XXA9ET200LI; NC2396838
+CAS No 67-64-1
+Synonyms 2-Propanone; Dimethyl ketone; (Certified ACS, HPLC, OPTIMA, Histological,
+Spectranalyzed, NF/FCC/EP, Pesticide, Electronic, GC Resolv, SAFE-COTE)
+Recommended Use Laboratory chemicals.
+Uses advised against Food, drug, pesticide or biocidal product use.
+Details of the supplier of the safety data sheet
+Company
+Fisher Scientific Company
+One Reagent Lane
+Fair Lawn, NJ 07410
+Tel: (201) 796-7100
+Emergency Telephone Number
+CHEMTREC�, Inside the USA: 800-424-9300
+CHEMTREC�, Outside the USA: 001-703-527-3887
+2. Hazard(s) identification
+Classification
+______________________________________________________________________________________________
+Page 1 / 9
+Acetone Revision Date 13-Oct-2023
+______________________________________________________________________________________________
+This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)
+Flammable liquids Category 2
+Serious Eye Damage/Eye Irritation Category 2
+Specific target organ toxicity (single exposure) Category 3
+Target Organs - Central nervous system (CNS).
+Specific target organ toxicity - (repeated exposure) Category 2
+Label Elements
+Signal Word
+Danger
+Hazard Statements
+Highly flammable liquid and vapor
+Causes serious eye irritation
+May cause drowsiness or dizziness
+May cause damage to organs through prolonged or repeated exposure
+Precautionary Statements
+Prevention
+Wash face, hands and any exposed skin thoroughly after handling
+Do not breathe dust/fume/gas/mist/vapors/spray
+Use only outdoors or in a well-ventilated area
+Keep away from heat/sparks/open flames/hot surfaces. - No smoking
+Keep container tightly closed
+Ground/bond container and receiving equipment
+Use explosion-proof electrical/ventilating/lighting equipment
+Use only non-sparking tools
+Take precautionary measures against static discharge
+Wear protective gloves/protective clothing/eye protection/face protection
+Keep cool
+Response
+Get medical attention/advice if you feel unwell
+Inhalation
+IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
+Call a POISON CENTER or doctor/physician if you feel unwell
+Skin
+IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower
+Eyes
+IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
+If eye irritation persists: Get medical advice/attention
+Fire
+In case of fire: Use CO2, dry chemical, or foam for extinction
+Storage
+Store in a well-ventilated place. Keep container tightly closed
+Store locked up
+Disposal
+______________________________________________________________________________________________
+Page 2 / 9
+Acetone Revision Date 13-Oct-2023
+______________________________________________________________________________________________
+Dispose of contents/container to an approved waste disposal plant
+Hazards not otherwise classified (HNOC)
+Repeated exposure may cause skin dryness or cracking
+3. Composition/Information on Ingredients
+Component CAS No Weight %
+Acetone 67-64-1 >95
+4. First-aid measures
+General Advice If symptoms persist, call a physician.
+Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get
+medical attention.
+Skin Contact Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists,
+call a physician.
+Inhalation Remove to fresh air. If not breathing, give artificial respiration. Get medical attention if
+symptoms occur.
+Ingestion Clean mouth with water and drink afterwards plenty of water.
+Most important symptoms and Difficulty in breathing. Symptoms of overexposure may be headache, dizziness, tiredness,
+effects nausea and vomiting: May cause pulmonary edema
+Notes to Physician Treat symptomatically
+5. Fire-fighting measures
+Suitable Extinguishing Media Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water mist may
+be used to cool closed containers.
+Unsuitable Extinguishing Media Water may be ineffective
+Flash Point -20 �C / -4 �F
+Method - CC (closed cup)
+Autoignition Temperature 465 �C / 869 �F
+Explosion Limits
+Upper 12.8 vol %
+Lower 2.5 vol %
+Oxidizing Properties Not oxidising
+Sensitivity to Mechanical ImpactNo information available
+Sensitivity to Static Discharge No information available
+Specific Hazards Arising from the Chemical
+Flammable. Risk of ignition. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may
+travel to source of ignition and flash back.
+Hazardous Combustion Products
+Carbon monoxide (CO). Carbon dioxide (CO2). Formaldehyde. Methanol.
+Protective Equipment and Precautions for Firefighters
+______________________________________________________________________________________________
+Page 3 / 9
+Acetone Revision Date 13-Oct-2023
+______________________________________________________________________________________________
+As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
+protective gear.
+NFPA
+Health Flammability Instability Physical hazards
+2 3 0 N/A
+6. Accidental release measures
+Personal Precautions Use personal protective equipment as required. Ensure adequate ventilation. Remove all
+sources of ignition. Take precautionary measures against static discharges.
+Environmental Precautions Should not be released into the environment.
+Methods for Containment and CleanSoak up with inert absorbent material. Keep in suitable, closed containers for disposal.
+Up Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.
+7. Handling and storage
+Handling Do not get in eyes, on skin, or on clothing. Wear personal protective equipment/face
+protection. Ensure adequate ventilation. Avoid ingestion and inhalation. Keep away from
+open flames, hot surfaces and sources of ignition. Use only non-sparking tools. To avoid
+ignition of vapors by static electricity discharge, all metal parts of the equipment must be
+grounded. Take precautionary measures against static discharges.
+Storage. Flammables area. Keep containers tightly closed in a dry, cool and well-ventilated place.
+Keep away from heat, sparks and flame. Incompatible Materials. Strong oxidizing agents.
+Strong reducing agents. Strong bases. Peroxides. Halogenated compounds. Alkali metals.
+Amines.
+8. Exposure controls / personal protection
+Exposure Guidelines
+Component ACGIH TLV OSHA PEL NIOSH Mexico OEL (TWA)
+Acetone TWA: 250 ppm (Vacated) TWA: 750 ppm IDLH: 2500 ppm TWA: 500 ppm
+STEL: 500 ppm (Vacated) TWA: 1800 mg/m3 TWA: 250 ppm STEL: 750 ppm
+(Vacated) STEL: 2400 TWA: 590 mg/m3
+mg/m3
+(Vacated) STEL: 1000 ppm
+TWA: 1000 ppm
+TWA: 2400 mg/m3
+Legend
+ACGIH - American Conference of Governmental Industrial Hygienists
+OSHA - Occupational Safety and Health Administration
+NIOSH: NIOSH - National Institute for Occupational Safety and Health
+Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations
+and safety showers are close to the workstation location. Use explosion-proof
+electrical/ventilating/lighting equipment.
+Personal Protective Equipment
+Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
+OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
+EN166.
+Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.
+Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
+______________________________________________________________________________________________
+Page 4 / 9
+Acetone Revision Date 13-Oct-2023
+______________________________________________________________________________________________
+EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
+exposure limits are exceeded or if irritation or other symptoms are experienced.
+Recommended Filter type: low boiling organic solvent. Type AX. Brown. conforming to EN371.
+Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.
+9. Physical and chemical properties
+Physical State Liquid
+Appearance Colorless
+Odor sweet
+Odor Threshold 19.8 ppm
+pH 7
+Melting Point/Range -95 �C / -139 �F
+Boiling Point/Range 56 �C / 132.8 �F
+Flash Point -20 �C / -4 �F
+Method - CC (closed cup)
+Evaporation Rate 5.6 (Butyl Acetate = 1.0)
+Flammability (solid,gas) Not applicable
+Flammability or explosive limits
+Upper 12.8 vol %
+Lower 2.5 vol %
+Vapor Pressure 247 mbar @ 20 �C
+Vapor Density 2.0
+Specific Gravity 0.790
+Solubility Soluble in water
+Partition coefficient; n-octanol/water No data available
+Autoignition Temperature 465 �C / 869 �F
+Decomposition Temperature > 4�C
+Viscosity 0.32 mPa.s @ 20 �C
+Molecular Formula C3 H6 O
+Molecular Weight 58.08
+VOC Content(%) 100
+Refractive index 1.358 - 1.359
+10. Stability and reactivity
+Reactive Hazard None known, based on information available
+Stability Stable under normal conditions.
+Conditions to Avoid Heat, flames and sparks. Incompatible products. Keep away from open flames, hot
+surfaces and sources of ignition.
+Incompatible Materials Strong oxidizing agents, Strong reducing agents, Strong bases, Peroxides, Halogenated
+compounds, Alkali metals, Amines
+Hazardous Decomposition ProductsCarbon monoxide (CO), Carbon dioxide (CO2), Formaldehyde, Methanol
+Hazardous Polymerization Hazardous polymerization does not occur.
+Hazardous Reactions None under normal processing.
+11. Toxicological information
+Acute Toxicity
+Product Information
+Component Information
+Component LD50 Oral LD50 Dermal LC50 Inhalation
+______________________________________________________________________________________________
+Page 5 / 9
+Acetone Revision Date 13-Oct-2023
+______________________________________________________________________________________________
+Acetone 5800 mg/kg ( Rat ) > 15800 mg/kg (rabbit) 76 mg/l, 4 h, (rat)
+> 7400 mg/kg (rat)
+Toxicologically Synergistic Carbon tetrachloride; Chloroform; Trichloroethylene; Bromodichloromethane;
+Products Dibromochloromethane; N-nitrosodimethylamine; 1,1,2-Trichloroethane; Styrene;
+Acetonitrile, 2,5-Hexanedione; Ethanol; 1,2-Dichlorobenzene
+Delayed and immediate effects as well as chronic effects from short and long-term exposure
+Irritation Irritating to eyes
+Sensitization No information available
+Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.
+Component CAS No IARC NTP ACGIH OSHA Mexico
+Acetone 67-64-1 Not listed Not listed Not listed Not listed Not listed
+Mutagenic Effects No information available
+Reproductive Effects No information available.
+Developmental Effects No information available.
+Teratogenicity No information available.
+STOT - single exposure Central nervous system (CNS)
+STOT - repeated exposure None known
+Aspiration hazard No information available
+Symptoms / effects,both acute and Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting:
+delayed May cause pulmonary edema
+Endocrine Disruptor Information No information available
+Other Adverse Effects The toxicological properties have not been fully investigated.
+12. Ecological information
+Ecotoxicity
+.
+Component Freshwater Algae Freshwater Fish Microtox Water Flea
+Acetone NOEC = 430 mg/l (algae; 96 Oncorhynchus mykiss: LC50 EC50 = 14500 mg/L/15 min EC50 = 8800 mg/L/48h
+h) = 5540 mg/l 96h EC50 = 12700 mg/L/48h
+Alburnus alburnus: LC50 = EC50 = 12600 mg/L/48h
+11000 mg/l 96h
+Leuciscus idus: LC50 =
+11300 mg/L/48h
+Salmo gairdneri: LC50 =
+6100 mg/L/24h
+Persistence and Degradability Persistence is unlikely based on information available.
+Bioaccumulation/ Accumulation No information available.
+Mobility Will likely be mobile in the environment due to its volatility.
+Component log Pow
+Acetone -0.24
+13. Disposal considerations
+Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
+hazardous waste. Chemical waste generators must also consult local, regional, and
+national hazardous waste regulations to ensure complete and accurate classification.
+______________________________________________________________________________________________
+Page 6 / 9
+Acetone Revision Date 13-Oct-2023
+______________________________________________________________________________________________
+Component RCRA - U Series Wastes RCRA - P Series Wastes
+Acetone - 67-64-1 U002 -
+14. Transport information
+DOT
+UN-No UN1090
+Proper Shipping Name ACETONE
+Hazard Class 3
+Packing Group II
+TDG
+UN-No UN1090
+Proper Shipping Name ACETONE
+Hazard Class 3
+Packing Group II
+IATA
+UN-No UN1090
+Proper Shipping Name ACETONE
+Hazard Class 3
+Packing Group II
+IMDG/IMO
+UN-No UN1090
+Proper Shipping Name ACETONE
+Hazard Class 3
+Packing Group II
+15. Regulatory information
+United States of America Inventory
+Component CAS No TSCA TSCA Inventory notification - TSCA - EPA Regulatory
+Active-Inactive Flags
+Acetone 67-64-1 X ACTIVE -
+Legend:
+TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)
+X - Listed
+'-' - Not Listed
+TSCA - Per 40 CFR 751, Regulation of Certain Chemical Not applicable
+Substances & Mixtures, Under TSCA Section 6(h) (PBT)
+TSCA 12(b) - Notices of Export Not applicable
+International Inventories
+Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea
+(KECL).
+Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL
+Acetone 67-64-1 X - 200-662-2 X X X X X KE-29367
+KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)
+U.S. Federal Regulations
+SARA 313 Not applicable
+SARA 311/312 Hazard Categories See section 2 for more information
+CWA (Clean Water Act) Not applicable
+______________________________________________________________________________________________
+Page 7 / 9
+Acetone Revision Date 13-Oct-2023
+______________________________________________________________________________________________
+Clean Air Act Not applicable
+OSHA - Occupational Safety and Not applicable
+Health Administration
+CERCLA This material, as supplied, contains one or more substances regulated as a hazardous
+substance under the Comprehensive Environmental Response Compensation and Liability
+Act (CERCLA) (40 CFR 302)
+Component Hazardous Substances RQs CERCLA EHS RQs
+Acetone 5000 lb -
+California Proposition 65 This product does not contain any Proposition 65 chemicals.
+U.S. State Right-to-Know
+Regulations
+Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island
+Acetone X X X - X
+U.S. Department of Transportation
+Reportable Quantity (RQ): Y
+DOT Marine Pollutant N
+DOT Severe Marine Pollutant N
+U.S. Department of Homeland This product does not contain any DHS chemicals.
+Security
+Other International Regulations
+Mexico - Grade Serious risk, Grade 3
+Authorisation/Restrictions according to EU REACH
+Component CAS No REACH (1907/2006) - REACH (1907/2006) - REACH Regulation (EC
+Annex XIV - Substances Annex XVII - Restrictions 1907/2006) article 59 -
+Subject to Authorization on Certain Dangerous Candidate List of
+Substances Substances of Very High
+Concern (SVHC)
+Acetone 67-64-1 - Use restricted. See item -
+75.
+(see link for restriction
+details)
+REACH links
+https://echa.europa.eu/substances-restricted-under-reach
+Safety, health and environmental regulations/legislation specific for the substance or mixture
+Component CAS No OECD HPV Persistent Organic Ozone Depletion Restriction of
+Pollutant Potential Hazardous
+Substances (RoHS)
+Acetone 67-64-1 Listed Not applicable Not applicable Not applicable
+Contains component(s) that meet a 'definition' of per & poly fluoroalkyl substance (PFAS)?
+Not applicable
+______________________________________________________________________________________________
+Page 8 / 9
+Acetone Revision Date 13-Oct-2023
+______________________________________________________________________________________________
+Other International Regulations
+Component CAS No Seveso III Directive Seveso III Directive Rotterdam Basel Convention
+(2012/18/EC) - (2012/18/EC) - Convention (PIC) (Hazardous Waste)
+Qualifying QuantitiesQualifying Quantities
+for Major Accident for Safety Report
+Notification Requirements
+Acetone 67-64-1 Not applicable Not applicable Not applicable Annex I - Y42
+16. Other information
+Prepared By Regulatory Affairs
+Thermo Fisher Scientific
+Email: EMSDS.RA@thermofisher.com
+Creation Date 28-Apr-2009
+Revision Date 13-Oct-2023
+Print Date 13-Oct-2023
+Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
+replacing the current legislation under 29 CFR 1910.1200 to align with the Globally
+Harmonized System of Classification and Labeling of Chemicals (GHS).
+Disclaimer
+The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
+date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
+transportation, disposal and release and is not to be considered a warranty or quality specification. The information
+relates only to the specific material designated and may not be valid for such material used in combination with any other
+materials or in any process, unless specified in the text
+End of SDS
+______________________________________________________________________________________________
+Page 9 / 9