Science Research Conversation 001: Live-seq replicate semantics

[safal207]

What changed

• adds the first live RESONANCE Science Research Conversation;
• converts a private researcher clarification into a scoped model correction without publishing the person's identity or wording;
• distinguishes cell = biological replicate for the narrow cell-heterogeneity question from the still-unresolved unit for held-out biological generalization;
• records plate = sub-batch, not independent biological replicate;
• makes plate-effect sensitivity the next discriminating test;
• links the conversation from the Science Desk manifesto.

Evidence discipline

The public technical metadata and the private semantic clarification remain separate evidence layers. The report explicitly marks private correspondence as not independently verifiable from public sources and does not imply endorsement.

Core lesson

A correction should reduce uncertainty without silently increasing authority.

blocked → expert replied → everything unlocked is rejected.

The intended path is:

blocked question → external correction → scope the correction → preserve unresolved dimensions → next discriminating test.

Related implementation

Kairos PR #15 now carries the corresponding external semantics overlay and CI gate.

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📥 Commits

Reviewing files that changed from the base of the PR and between bc8cbc2 and 9293ec4.

📒 Files selected for processing (2)

• reports/science/conversations/001-live-seq-replicate-semantics.md
• science/README.md

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