Regulatory target prioritization

results/permutation_analysis/prioritized_setbp1_targets.csv

@@ -0,0 +1,35 @@
+Target_Gene,Method,Spearman_Rho,GO_Term
+BAZ2B,GO:0010467; GO:0006325,,Gene expression; Chromatin organization
+BMPR1B,GO:0010467; GO:0051254,,Gene expression; Positive regulation RNA metabolic process
+BMPR2,GTEx_Coexpr; GO:0010467; GO:0051254; GO:0035556,0.7474918810946,Gene expression; Positive regulation RNA metabolic process; Intracellular signal transduction
+BPTF,GTEx_Coexpr; Brainspan_Coexpr; GO:0010467; GO:0051254; GO:0006325,0.711537323508429; 0.810125210856751,Gene expression; Positive regulation RNA metabolic process; Chromatin organization
+BRCA1,GO:0010467; GO:0051254; GO:0006325; GO:0035556; GO:0010564,,Gene expression; Positive regulation RNA metabolic process; Chromatin organization; Intracellular signal transduction; Regulation of cell cycle process
+CDK8,GTEx_Coexpr; Brainspan_Coexpr; GO:0010467; GO:0051254,0.715980907220096; 0.726755256041085,Gene expression; Positive regulation RNA metabolic process
+CDKN1A,GO:0010467; GO:0035556; GO:0010564,,Gene expression; Intracellular signal transduction; Regulation of cell cycle process
+CHEK1,GO:0010467; GO:0006325; GO:0035556; GO:0010564,,Gene expression; Chromatin organization; Intracellular signal transduction; Regulation of cell cycle process
+EED,GO:0010467; GO:0006325; GO:0003682,,Gene expression; Chromatin organization; Chromatin binding
+EPHA7,Brainspan_Coexpr; GO:0035556; GO:0007416,0.8350026342238,Intracellular signal transduction; Synapse assembly
+EPRS,Brainspan_Coexpr,0.821415914810745,
+ERBB4,GO:0010467; GO:0051254; GO:0051896; GO:0035556; GO:0007416,,Gene expression; Positive regulation RNA metabolic process; Regulation of protein kinase B signaling; Intracellular signal transduction; Synapse assembly
+GGCX,GTEx_Coexpr,0.756490182916181,
+HDAC9,GO:0010467; GO:0006325,,Gene expression; Chromatin organization
+HGF,GO:0010467; GO:0051254; GO:0051896; GO:0035556,,Gene expression; Positive regulation RNA metabolic process; Regulation of protein kinase B signaling; Intracellular signal transduction
+KAT6A,Brainspan_Coexpr; GO:0010467; GO:0051254; GO:0006325; GO:0003682; GO:0035556,0.867259060324318,Gene expression; Positive regulation RNA metabolic process; Chromatin organization; Chromatin binding; Intracellular signal transduction
+KMT2A,GTEx_Coexpr; GO:0010467; GO:0051254; GO:0006325; GO:0003682,0.76702022179054,Gene expression; Positive regulation RNA metabolic process; Chromatin organization; Chromatin binding
+MAP4K1,GO:0035556,,Intracellular signal transduction
+MGAT2,Brainspan_Coexpr,0.724337445865331,
+NDUFAB1,GO:0010467,,Gene expression
+NFE2L2,GO:0010467; GO:0051254; GO:0035556,,Gene expression; Positive regulation RNA metabolic process; Intracellular signal transduction
+PARG,GTEx_Coexpr,0.689870605098776,
+PBRM1,GTEx_Coexpr; Brainspan_Coexpr; GO:0010467; GO:0006325; GO:0003682; GO:0010564,0.784728267921418; 0.899652829181532,Gene expression; Chromatin organization; Chromatin binding; Regulation of cell cycle process
+PDE4D,Brainspan_Coexpr; GO:0010467; GO:0035556,0.746948212122413,Gene expression; Intracellular signal transduction
+PHF8,GTEx_Coexpr; GO:0010467; GO:0051254; GO:0006325; GO:0003682,0.664580654846671,Gene expression; Positive regulation RNA metabolic process; Chromatin organization; Chromatin binding
+PITRM1,GTEx_Coexpr; GO:0010467,0.800958901344844,Gene expression
+PKN2,GTEx_Coexpr; GO:0035556; GO:0010564,0.682733654788693,Intracellular signal transduction; Regulation of cell cycle process
+PRKACB,GO:0010467; GO:0035556,,Gene expression; Intracellular signal transduction
+PTGS2,GO:0010467; GO:0035556,,Gene expression; Intracellular signal transduction
+PTPN13,GO:0051896; GO:0035556; GO:0007416,,Regulation of protein kinase B signaling; Intracellular signal transduction; Synapse assembly
+PTPRC,GO:0010467; GO:0035556,,Gene expression; Intracellular signal transduction
+RAD52,GTEx_Coexpr,0.713643644110946,
+STK17B,GO:0035556,,Intracellular signal transduction
+TFPI,GTEx_Coexpr,0.670779105480738,

results/permutation_analysis/prioritized_target_coexpression.csv

@@ -0,0 +1,131 @@
+Target_Gene,Spearman_Rho,P_Value,FDR,Method
+RNF217,0.840891425714916,0,0,GTEx_Coexpr
+MYO9A,0.8390821820084338,0,0,GTEx_Coexpr
+UBR1,0.8236870308086461,0,0,GTEx_Coexpr
+MLLT10,0.8230857009832709,0,0,GTEx_Coexpr
+EPC2,0.816869184030563,0,0,GTEx_Coexpr
+RALGAPA1,0.8104387281195069,0,0,GTEx_Coexpr
+DCAF8,0.8012994667679644,0,0,GTEx_Coexpr
+PITRM1,0.8009589013448437,0,0,GTEx_Coexpr
+PBRM1,0.7847282679214185,0,0,GTEx_Coexpr
+IPO8,0.7796582882643719,0,0,GTEx_Coexpr
+ATP9B,0.7726039181088198,0,0,GTEx_Coexpr
+ZFPM2,0.7724182273098258,0,0,GTEx_Coexpr
+TBC1D23,0.7715737178414818,0,0,GTEx_Coexpr
+ESYT1,0.7715601969412416,0,0,GTEx_Coexpr
+EPC1,0.7693798677668975,0,0,GTEx_Coexpr
+CCDC50,0.7688489620428584,0,0,GTEx_Coexpr
+KAT7,0.7687530389441259,0,0,GTEx_Coexpr
+KMT2A,0.7670202217905395,0,0,GTEx_Coexpr
+ZEB1,0.7619917916837197,0,0,GTEx_Coexpr
+INO80D,0.7593816752528586,0,0,GTEx_Coexpr
+GGCX,0.756490182916181,0,0,GTEx_Coexpr
+TTC23,0.7507166573294056,0,0,GTEx_Coexpr
+BMPR2,0.7474918810945999,0,0,GTEx_Coexpr
+CWF19L2,0.7391402818207754,0,0,GTEx_Coexpr
+BMI1,0.7379064473392568,0,0,GTEx_Coexpr
+ZZEF1,0.7379008632291393,0,0,GTEx_Coexpr
+CHERP,0.7344391458096833,0,0,GTEx_Coexpr
+REEP3,0.7286550009563179,0,0,GTEx_Coexpr
+COL5A2,0.7284376040921356,0,0,GTEx_Coexpr
+NBR1,0.7245617593047815,0,0,GTEx_Coexpr
+TMTC3,0.7226914832831698,0,0,GTEx_Coexpr
+RBMS3,0.720715773126173,0,0,GTEx_Coexpr
+ZMYND11,0.7199296437460875,0,0,GTEx_Coexpr
+TIMM23B,0.7181462446481214,0,0,GTEx_Coexpr
+ZC3H10,0.7180324747959462,0,0,GTEx_Coexpr
+CDK8,0.7159809072200963,0,0,GTEx_Coexpr
+ARID5B,0.7138676651009463,0,0,GTEx_Coexpr
+RAD52,0.7136436441109464,0,0,GTEx_Coexpr
+BPTF,0.7115373235084295,0,0,GTEx_Coexpr
+ACTA2,0.71144787918701,0,0,GTEx_Coexpr
+NUDT9,0.7083930145296485,0,0,GTEx_Coexpr
+NAALADL2,0.7049563171171831,0,0,GTEx_Coexpr
+BAG5,0.7049074964618852,0,0,GTEx_Coexpr
+PDPR,0.7021572429222492,0,0,GTEx_Coexpr
+FAF1,0.697608819191427,0,0,GTEx_Coexpr
+RIOK2,0.6971399082050161,0,0,GTEx_Coexpr
+TANC1,0.6970615667419872,0,0,GTEx_Coexpr
+MBNL1,0.6954854270496389,0,0,GTEx_Coexpr
+CEP44,0.6942782495488128,0,0,GTEx_Coexpr
+JMJD1C,0.6920506583096422,0,0,GTEx_Coexpr
+PPP3CC,0.6910649104120933,0,0,GTEx_Coexpr
+PARG,0.6898706050987761,0,0,GTEx_Coexpr
+WDR75,0.6845241005777399,0,0,GTEx_Coexpr
+BET1L,0.6841960228971125,0,0,GTEx_Coexpr
+FRZB,0.6836835073553298,0,0,GTEx_Coexpr
+SUPT5H,0.6834033866980204,0,0,GTEx_Coexpr
+PKN2,0.6827336547886925,0,0,GTEx_Coexpr
+E4F1,0.6802659037190822,0,0,GTEx_Coexpr
+FBXO8,0.6779230817658755,0,0,GTEx_Coexpr
+CHD2,0.6747043484877061,0,0,GTEx_Coexpr
+UTP14A,0.6716843489426706,0,0,GTEx_Coexpr
+RNF139,0.6707941030803772,0,0,GTEx_Coexpr
+TFPI,0.6707791054807377,0,0,GTEx_Coexpr
+EIF4B,0.670426056616079,0,0,GTEx_Coexpr
+NAA30,0.6684199360192891,0,0,GTEx_Coexpr
+USP48,0.6664224211523371,0,0,GTEx_Coexpr
+AFF1,0.6650660374207301,0,0,GTEx_Coexpr
+PHF8,0.6645806548466711,0,0,GTEx_Coexpr
+PBRM1,0.8996528291815317,5.193292567810596e-190,1.4697017966903987e-187,Brainspan_Coexpr
+EPC2,0.8762826658548637,1.1355972204798998e-167,1.606870066979058e-165,Brainspan_Coexpr
+EPC1,0.87202904141237,4.2832205362191945e-164,4.0405047058334403e-162,Brainspan_Coexpr
+KAT6A,0.8672590603243179,3.1127564134570265e-160,2.2022751625208465e-158,Brainspan_Coexpr
+EPHA7,0.8350026342237999,1.554269060737794e-137,8.797162883775917e-136,Brainspan_Coexpr
+CHERP,0.8332364869232324,1.9505681581718096e-136,9.200179812710367e-135,Brainspan_Coexpr
+JMJD1C,0.829780708979109,2.529303147305518e-134,1.0225611295535167e-132,Brainspan_Coexpr
+LEO1,0.8284393994049094,1.6228175973952227e-133,5.740717250785599e-132,Brainspan_Coexpr
+NCOA5,0.8238664195116253,8.140169847519039e-131,2.559631185386542e-129,Brainspan_Coexpr
+EPRS,0.8214159148107448,2.1167805269964606e-129,5.990488891399984e-128,Brainspan_Coexpr
+SEMA3A,0.8106506754849587,1.9693470866781127e-123,5.066592959362779e-122,Brainspan_Coexpr
+BPTF,0.8101252108567508,3.76554009118376e-123,8.880398715041698e-122,Brainspan_Coexpr
+TAF5,0.807397303118699,1.0549756973773712e-121,2.296600941213816e-120,Brainspan_Coexpr
+COX4I1,-0.7988146566553582,2.6920388850845556e-117,5.441764317706638e-116,Brainspan_Coexpr
+DIEXF,0.795646457085308,1.0071212605623211e-115,1.9001021115942462e-114,Brainspan_Coexpr
+RP11-277P12.6,-0.7931057016452419,1.756225695962438e-114,3.1063241997335616e-113,Brainspan_Coexpr
+ETFDH,-0.7918503891857853,7.104770329187421e-114,1.1827352959764944e-112,Brainspan_Coexpr
+INO80D,0.79156456230413,9.75366087700904e-114,1.5334922378853102e-112,Brainspan_Coexpr
+MLLT10,0.7882284696752022,3.7982391608918364e-112,5.657377276486262e-111,Brainspan_Coexpr
+EIF4B,0.7879218750977395,5.300302652475869e-112,7.499928253253356e-111,Brainspan_Coexpr
+ANP32A,0.7743391348044478,8.017808306260882e-106,1.080495119367538e-104,Brainspan_Coexpr
+KLHDC9,-0.7738174402772361,1.357569109536665e-105,1.7463275363585282e-104,Brainspan_Coexpr
+TPD52L1,-0.7610120031654475,3.639392048656096e-100,4.478034564215978e-99,Brainspan_Coexpr
+C4orf46,0.7566507294757406,2.1494242026551718e-98,2.5345293722975565e-97,Brainspan_Coexpr
+MTND5P11,-0.7551099905913948,8.894982566998288e-98,1.0069120265842063e-96,Brainspan_Coexpr
+ARRDC3,0.75204705676295,1.4515814087778164e-96,1.5799905334004696e-95,Brainspan_Coexpr
+RPIA,0.7517068502119513,1.9744314367952134e-96,2.0694966541223903e-95,Brainspan_Coexpr
+CCDC50,0.7499507705524081,9.58571355793698e-96,9.688417631772018e-95,Brainspan_Coexpr
+ARL5B,0.7492345769624533,1.819002104942758e-95,1.7750951575820706e-94,Brainspan_Coexpr
+PDE4D,0.7469482121224126,1.3857857781923623e-94,1.3072579174281282e-93,Brainspan_Coexpr
+UTP14A,0.7407309978711025,3.107612509634212e-92,2.836949484601555e-91,Brainspan_Coexpr
+C4orf36,-0.7385191702621436,2.0534979010351325e-91,1.8160622062279454e-90,Brainspan_Coexpr
+KLHL1,0.7282073266595911,1.067768227684585e-87,9.15692146771932e-87,Brainspan_Coexpr
+FAF1,0.7270254028953836,2.776396577490415e-87,2.3109418571464344e-86,Brainspan_Coexpr
+MED29,-0.7267797769349299,3.384179617567856e-87,2.7134059890128766e-86,Brainspan_Coexpr
+CDK8,0.7267552560410849,3.451682530193058e-87,2.7134059890128766e-86,Brainspan_Coexpr
+MGAT2,0.724337445865331,2.3945140996815147e-86,1.8314797032699149e-85,Brainspan_Coexpr
+NSUN6,0.7221188053987667,1.390728602196525e-85,1.0357268274253071e-84,Brainspan_Coexpr
+NEBL,-0.7212387221611747,2.781341420442779e-85,2.0182554409879655e-84,Brainspan_Coexpr
+CHD2,0.7199546280059466,7.609774448730088e-85,5.383915422476537e-84,Brainspan_Coexpr
+SET,0.7193114966711217,1.2571274056587338e-84,8.677245263449308e-84,Brainspan_Coexpr
+ASB7,0.7172030334180581,6.454081713678158e-84,4.3488217261212345e-83,Brainspan_Coexpr
+TAF13,-0.7166272928391065,1.0062464156349854e-83,6.622505479644205e-83,Brainspan_Coexpr
+EIF3D,0.7060276777504164,2.94843652392418e-80,1.8963807642512335e-79,Brainspan_Coexpr
+ST8SIA4,0.7024050639483449,4.1604938794666977e-79,2.6164883730868347e-78,Brainspan_Coexpr
+CTNNBL1,0.6997359833691623,2.8511815086808275e-78,1.7540964499058134e-77,Brainspan_Coexpr
+RNF111,0.6964448457122839,2.9718333970820386e-77,1.7894230880302487e-76,Brainspan_Coexpr
+ZC3H10,0.6950595820188451,7.895542075076033e-77,4.655080015096911e-76,Brainspan_Coexpr
+CDKN2B,-0.6943851114360652,1.2680092026490292e-76,7.323400088768884e-76,Brainspan_Coexpr
+CSRNP3,0.6921310032923886,6.117808962340094e-76,3.462679872684494e-75,Brainspan_Coexpr
+SOX2-OT,-0.6899719135680192,2.7250559448783583e-75,1.5121388870599516e-74,Brainspan_Coexpr
+ACTA2,-0.6871438371445668,1.8905956255154546e-74,1.0289203115786032e-73,Brainspan_Coexpr
+MIR4461,-0.6854989312355636,5.77388982814577e-74,3.083039285594817e-73,Brainspan_Coexpr
+DNAJC19,-0.6838761361243224,1.7245614069128133e-73,9.037979225117153e-73,Brainspan_Coexpr
+WDR75,0.6793497792911042,3.514937285352324e-72,1.8085950031903776e-71,Brainspan_Coexpr
+GNL3,0.6793224226476309,3.5789750460865523e-72,1.8086606036473113e-71,Brainspan_Coexpr
+DNAJC12,-0.6772208819598365,1.4241936218958036e-71,7.070996403447585e-71,Brainspan_Coexpr
+ZZEF1,0.6641655910974141,5.895870184580735e-68,2.8767780383385313e-67,Brainspan_Coexpr
+VAMP8,-0.6637569095333314,7.600243107522766e-68,3.645540338015157e-67,Brainspan_Coexpr
+SLC38A11,-0.6628154127749565,1.3621381232645518e-67,6.424751481397803e-67,Brainspan_Coexpr
+KLRC2,-0.6598509159233871,8.435331365720325e-67,3.9134406172112334e-66,Brainspan_Coexpr
+TRDMT1,0.6567367331066833,5.601661177386085e-66,2.556887279355261e-65,Brainspan_Coexpr