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content/post/flowingdata-com-2025-01-13-fighting-fire-from-the-sky.md
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| --- | ||
| title: Fighting fire from the sky | ||
| date: '2025-01-13' | ||
| linkTitle: https://flowingdata.com/2025/01/13/fighting-fire-from-the-sky/ | ||
| source: FlowingData | ||
| description: <p><a href="https://flowingdata.com/2025/01/13/fighting-fire-from-the-sky/"><img | ||
| src="https://flowingdata.com/wp-content/uploads/2025/01/Reuters-firefight-air-750x701.png" | ||
| style="max-width:100%;height:auto" /></a></p>For Reuters, Simon Scarr, Vijdan Mohammad | ||
| Kawoosa, and Sudev Kiyada use flight data…<p><strong>Tags:</strong> <a href="https://flowingdata.com/tag/firefight/" | ||
| rel="tag">firefight</a>, <a href="https://flowingdata.com/tag/flight/" rel="tag">flight</a>, | ||
| <a href="https://flowingdata.com/tag/reuters/" rel="tag">Reuters</a>, <a href="https://flowingdata.com/tag/wildfire/" | ||
| ... | ||
| disable_comments: true | ||
| --- | ||
| <p><a href="https://flowingdata.com/2025/01/13/fighting-fire-from-the-sky/"><img src="https://flowingdata.com/wp-content/uploads/2025/01/Reuters-firefight-air-750x701.png" style="max-width:100%;height:auto" /></a></p>For Reuters, Simon Scarr, Vijdan Mohammad Kawoosa, and Sudev Kiyada use flight data…<p><strong>Tags:</strong> <a href="https://flowingdata.com/tag/firefight/" rel="tag">firefight</a>, <a href="https://flowingdata.com/tag/flight/" rel="tag">flight</a>, <a href="https://flowingdata.com/tag/reuters/" rel="tag">Reuters</a>, <a href="https://flowingdata.com/tag/wildfire/" ... |
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...d93e79a84e58982e9878fe4b88ee6b593e5baa6e58fafe8a786e58c96e59bbe-e7bc98e8b5b7.md
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| --- | ||
| title: 首次人体的剂量与浓度可视化图_缘起 | ||
| date: '2025-01-13' | ||
| linkTitle: https://s0521.github.io/cn/2025/01/%E9%A6%96%E6%AC%A1%E4%BA%BA%E4%BD%93%E7%9A%84%E5%89%82%E9%87%8F%E4%B8%8E%E6%B5%93%E5%BA%A6%E5%8F%AF%E8%A7%86%E5%8C%96%E5%9B%BE_%E7%BC%98%E8%B5%B7/ | ||
| source: 中文博客 on Yongchao Fu | 付永超 | ||
| description: |- | ||
| 引言： 首次人体试验（FIH）的剂量的预测，在本质上有两种对药效进行假设的思路： | ||
| 1.假设AUC相同，药效相同（比如：基于体表面积归一化的方法） | ||
| 2.假设浓度相同，药效相同（比如：直接使用mg/kg外推的方法） | ||
| 正文： 目前的异速缩放大部分主要是围绕AUC进行的，这对小分子药物来说非常友好。 | ||
| 但对大分子来说由于其性质，有时剂量的物种间外推可以直接mg/kg外推，这本质上是基于“浓度相同药效相同”的假设。 | ||
| 在阅读文献的过程中，我看到了罗氏对“CEA-IL2v”分子FIH预测1时绘制的可视化图表，感觉十分卓越与惊艳！ | ||
| 这张图完美融合了体外药理、体外药效、体内药效、毒理、临床剂量的信息，非常棒！ | ||
| 图表解释（笔者对此的解读，非该图作者的解读）： 最下方一行的浅蓝色菱形为计划用于首次人体实验的剂量，起始剂量=0.1mg（0.2nmol/L），最大剂量=3 ... | ||
| disable_comments: true | ||
| --- | ||
| 引言： 首次人体试验（FIH）的剂量的预测，在本质上有两种对药效进行假设的思路： | ||
| 1.假设AUC相同，药效相同（比如：基于体表面积归一化的方法） | ||
| 2.假设浓度相同，药效相同（比如：直接使用mg/kg外推的方法） | ||
| 正文： 目前的异速缩放大部分主要是围绕AUC进行的，这对小分子药物来说非常友好。 | ||
| 但对大分子来说由于其性质，有时剂量的物种间外推可以直接mg/kg外推，这本质上是基于“浓度相同药效相同”的假设。 | ||
| 在阅读文献的过程中，我看到了罗氏对“CEA-IL2v”分子FIH预测1时绘制的可视化图表，感觉十分卓越与惊艳！ | ||
| 这张图完美融合了体外药理、体外药效、体内药效、毒理、临床剂量的信息，非常棒！ | ||
| 图表解释（笔者对此的解读，非该图作者的解读）： 最下方一行的浅蓝色菱形为计划用于首次人体实验的剂量，起始剂量=0.1mg（0.2nmol/L），最大剂量=3 ... |
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...8982e9878fe4b88ee6b593e5baa6e58fafe8a786e58c96e59bbee4bdbfe794a8e8afb4e6988e.md
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| --- | ||
| title: FurtPlot首次人体的剂量与浓度可视化图使用说明 | ||
| date: '2025-01-13' | ||
| linkTitle: https://s0521.github.io/cn/2025/01/furtplot%E9%A6%96%E6%AC%A1%E4%BA%BA%E4%BD%93%E7%9A%84%E5%89%82%E9%87%8F%E4%B8%8E%E6%B5%93%E5%BA%A6%E5%8F%AF%E8%A7%86%E5%8C%96%E5%9B%BE%E4%BD%BF%E7%94%A8%E8%AF%B4%E6%98%8E/ | ||
| source: 中文博客 on Yongchao Fu | 付永超 | ||
| description: |- | ||
| 工具名称：Furt Plot First in hUman dose and concentRaTion plot，Furt Plot，首次人体的剂量与浓度可视化图。 | ||
| [TOC] | ||
| 使用前需要准备的数据与信息： 分子的分子量、药理试验测得亲和力常数Kd、毒理研究测得Cmax，其他有用的药理学或药效学对应的药物的浓度数据。 | ||
| 使用步骤： 1.在浏览器中输入以下网址打开工具所在的页面： https://furt.netlify.app/ | ||
| 2.阅读使用说明 3.在“1、输入分子量”中输入分子量。 4.在“3、录入数据”中调整计划录入数据的行数 5.在“3、录入数据”中根据列名信息录入数据 其中“纵坐标”、“浓度数据1”、“单位”为必填信息，如果缺少这些信息本行数据可能无法在图 ... | ||
| disable_comments: true | ||
| --- | ||
| 工具名称：Furt Plot First in hUman dose and concentRaTion plot，Furt Plot，首次人体的剂量与浓度可视化图。 | ||
| [TOC] | ||
| 使用前需要准备的数据与信息： 分子的分子量、药理试验测得亲和力常数Kd、毒理研究测得Cmax，其他有用的药理学或药效学对应的药物的浓度数据。 | ||
| 使用步骤： 1.在浏览器中输入以下网址打开工具所在的页面： https://furt.netlify.app/ | ||
| 2.阅读使用说明 3.在“1、输入分子量”中输入分子量。 4.在“3、录入数据”中调整计划录入数据的行数 5.在“3、录入数据”中根据列名信息录入数据 其中“纵坐标”、“浓度数据1”、“单位”为必填信息，如果缺少这些信息本行数据可能无法在图 ... |
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...ce-two-different-opinion-field-inversions-that-differ-in-some-important-ways.md
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| --- | ||
| title: 'The theory crisis in physics compared to the replication crisis in social | ||
| science: Two different opinion-field inversions that differ in some important ways' | ||
| date: '2025-01-13' | ||
| linkTitle: https://statmodeling.stat.columbia.edu/2025/01/13/the-theory-crisis-in-physics-compared-to-the-replication-crisis-in-social-science-two-different-opinion-field-inversions-that-differ-in-some-important-ways/ | ||
| source: Statistical Modeling, Causal Inference, and Social Science | ||
| description: 'Yesterday we discussed an “opinion-field inversion” in theoretical | ||
| physics: in the prestige news media and publicity complex (NPR, Ted, etc), string | ||
| theory reigns supreme; in elite physics departments, string theory is where it’s | ||
| at, but then there’s a middle range … <a href="https://statmodeling.stat.columbia.edu/2025/01/13/the-theory-crisis-in-physics-compared-to-the-replication-crisis-in-social-science-two-different-opinion-field-inversions-that-differ-in-some-important-ways/">Continue | ||
| reading <span class="meta-nav">→</span></a> ...' | ||
| disable_comments: true | ||
| --- | ||
| Yesterday we discussed an “opinion-field inversion” in theoretical physics: in the prestige news media and publicity complex (NPR, Ted, etc), string theory reigns supreme; in elite physics departments, string theory is where it’s at, but then there’s a middle range … <a href="https://statmodeling.stat.columbia.edu/2025/01/13/the-theory-crisis-in-physics-compared-to-the-replication-crisis-in-social-science-two-different-opinion-field-inversions-that-differ-in-some-important-ways/">Continue reading <span class="meta-nav">→</span></a> ... |
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...ww-jihongzhang-org-posts-lectures-2025-01-13-experiment-design-syllabus-html.md
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| --- | ||
| title: ESRM 64103 - EXPERIMENTAL DESIGN IN EDUC | ||
| title: 'ESRM 64103: EXPERIMENTAL DESIGN IN EDUC' | ||
| date: '2025-01-13' | ||
| linkTitle: https://www.jihongzhang.org/posts/Lectures/2025-01-13-Experiment-Design/syllabus.html | ||
| source: Jihong Z. - Play Harder and Learn Harder | ||
| description: |2- | ||
| <section id="general-information" class="level1" data-number="1"> | ||
| <div class="quarto-figure quarto-figure-center"> | ||
| <figure class="figure"> | ||
| <p><a href="images/logo_ESRM64103.png" class="lightbox" data-gallery="quarto-lightbox-gallery-1"><img src="https://www.jihongzhang.org/posts/Lectures/2025-01-13-Experiment-Design/images/logo_ESRM64103.png" class="img-fluid quarto-figure quarto-figure-center figure-img" width="512"></a></p> | ||
| </figure> | ||
| </div> | ||
| <section id="general-information" class="level1" data-number="1"> | ||
| <h1 data-number="1"><span class="header-section-number">1</span> General Information</h1> | ||
| <hr> | ||
| <ul> | ||
| <li>Course Code: ESRM 64103</li> | ||
| <li>Credits: 3 CH</li> | ||
| <li>Course time and location: Mon 17:00-19:45; GRAD 210</li> | ||
| <li>Instructor: Dr. Jihong Zhang</li> | ||
| <li>Contact Information: <a href="mailto:[email protected]">[email protected]</a></li> | ||
| <li>Personal Website: <a href="http://jihongzhang.org" class="uri">http://jihongzhang.org</a></li> | ||
| <li>Office Location: GRAD 133B</li> | ||
| <li>Office Hours: Monday 2:00-5:00PM or by appointment</li> | ||
| <li> ... | ||
| <li>Credits: 3 ... | ||
| disable_comments: true | ||
| --- | ||
| <section id="general-information" class="level1" data-number="1"> | ||
| <div class="quarto-figure quarto-figure-center"> | ||
| <figure class="figure"> | ||
| <p><a href="images/logo_ESRM64103.png" class="lightbox" data-gallery="quarto-lightbox-gallery-1"><img src="https://www.jihongzhang.org/posts/Lectures/2025-01-13-Experiment-Design/images/logo_ESRM64103.png" class="img-fluid quarto-figure quarto-figure-center figure-img" width="512"></a></p> | ||
| </figure> | ||
| </div> | ||
| <section id="general-information" class="level1" data-number="1"> | ||
| <h1 data-number="1"><span class="header-section-number">1</span> General Information</h1> | ||
| <hr> | ||
| <ul> | ||
| <li>Course Code: ESRM 64103</li> | ||
| <li>Credits: 3 CH</li> | ||
| <li>Course time and location: Mon 17:00-19:45; GRAD 210</li> | ||
| <li>Instructor: Dr. Jihong Zhang</li> | ||
| <li>Contact Information: <a href="mailto:[email protected]">[email protected]</a></li> | ||
| <li>Personal Website: <a href="http://jihongzhang.org" class="uri">http://jihongzhang.org</a></li> | ||
| <li>Office Location: GRAD 133B</li> | ||
| <li>Office Hours: Monday 2:00-5:00PM or by appointment</li> | ||
| <li> ... | ||
| <li>Credits: 3 ... |
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content/post/www-r-bloggers-com-2025-01-bayesian-meta-analysis-with-brms.md
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| --- | ||
| title: Bayesian Meta-Analysis with brms | ||
| date: '2025-01-13' | ||
| linkTitle: https://www.r-bloggers.com/2025/01/bayesian-meta-analysis-with-brms/ | ||
| source: R-bloggers | ||
| description: |- | ||
| <div style = "width:60%; display: inline-block; float:left; "> | ||
| <p>In our previous post, Examining Meta Analysis, we contrasted a frequentist version of a meta analysis conducted with R’s meta package with a Bayesian meta analysis done mostly in stan using the rstan package as a front end. We did this to hint a...</p></div> | ||
| <div style = "width: 40%; display: inline-block; float:right;"></div> | ||
| <div style="clear: both;"></div> | ||
| <strong>Continue reading</strong>: <a href="https://www.r-bloggers.com/2025/01/bayesian-meta-analysis-with-brms/">Bayesian Meta-Analysis with ... | ||
| disable_comments: true | ||
| --- | ||
| <div style = "width:60%; display: inline-block; float:left; "> | ||
| <p>In our previous post, Examining Meta Analysis, we contrasted a frequentist version of a meta analysis conducted with R’s meta package with a Bayesian meta analysis done mostly in stan using the rstan package as a front end. We did this to hint a...</p></div> | ||
| <div style = "width: 40%; display: inline-block; float:right;"></div> | ||
| <div style="clear: both;"></div> | ||
| <strong>Continue reading</strong>: <a href="https://www.r-bloggers.com/2025/01/bayesian-meta-analysis-with-brms/">Bayesian Meta-Analysis with ... |
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content/post/www-r-bloggers-com-2025-01-identifying-data-gaps-with-r.md
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| --- | ||
| title: Identifying data gaps with R | ||
| date: '2025-01-13' | ||
| linkTitle: https://www.r-bloggers.com/2025/01/identifying-data-gaps-with-r/ | ||
| source: R-bloggers | ||
| description: |- | ||
| <div style = "width:60%; display: inline-block; float:left; "> In this post, Giles outlines a simple approach that can be used to identify potential 'data gaps' using R. Data gaps are assumed to denote the difference between the data required to achieve an outcome and the currently data available. To demonstrate how the methodology might be applied, the availability ...</div> | ||
| <div style = "width: 40%; display: inline-block; float:right;"></div> | ||
| <div style="clear: both;"></div> | ||
| <strong>Continue reading</strong>: <a href="https://www.r-bloggers.com/2025/01/identifying-data-gaps-with-r/">Identifyin ... | ||
| disable_comments: true | ||
| --- | ||
| <div style = "width:60%; display: inline-block; float:left; "> In this post, Giles outlines a simple approach that can be used to identify potential 'data gaps' using R. Data gaps are assumed to denote the difference between the data required to achieve an outcome and the currently data available. To demonstrate how the methodology might be applied, the availability ...</div> | ||
| <div style = "width: 40%; display: inline-block; float:right;"></div> | ||
| <div style="clear: both;"></div> | ||
| <strong>Continue reading</strong>: <a href="https://www.r-bloggers.com/2025/01/identifying-data-gaps-with-r/">Identifyin ... |