Just-DNA-Seq is an open-source personal genomics platform designed to unlock the secrets of your DNA. We empower you with transparent insights into your genetic predispositions—covering longevity, health risks, and drug responses—so you can make informed decisions about your well-being.
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Personalized Genomic Reports:
Upload your VCF files to generate detailed analyses on longevity-associated variants, disease risks, polygenic risk scores (PRS), and pharmacogenetics. -
Modular & Transparent:
Built on the robust OakVar framework, our system lets you mix and match analysis modules to suit your interests—all while keeping the algorithms and data sources open and transparent. -
Privacy & Flexibility:
Run analyses locally or on our server, ensuring that your genomic data remains private and secure.
Core Analysis Modules
- oakvar-longevity – OakVar modules for longevity and health risk analysis.
- longevity2reporter – Generates comprehensive longevity reports.
- just_longevitymap – Leverages curated data from LongevityMap.
- just_prs – Calculates polygenic risk scores (PRS) for various traits.
- just_drugs – Analyzes pharmacogenetics for drug efficacy and side effects.
Health & Disease Specific Modules
- just_cancer – Analyzes germline cancer risks.
- just_cardio – Evaluates hereditary cardiovascular disease risks.
- just_coronary – Assesses coronary artery disease risks.
- just_lipidmetabolism – Explores lipid metabolism disorders.
- just_thrombophilia – Evaluates thrombophilia predispositions.
Experimental & Specialized Modules
- superhumanreporter – Reports on rare "superhuman" gene variants.
- just_superhuman – Identifies exceptional "superhuman" SNPs.
Bioinformatics Pipelines & Advanced Tools
- dna-seq – WDL pipelines for sequencing data processing.
- neural_networks – Deep learning models for predicting genetic phenotypes.
Websites & Documentation
- dna-seq.github.io – Official project website.
- report_example – Example analysis reports.
- just-dna-seq-docs – Comprehensive documentation and guides.
Auxiliary & Support Tools
- my_genes_and_longevity_comic – A fun comic explaining genetics and longevity.
- containers – Docker containers for our workflows.
- modules-preprocessing – Tools for data cleaning and preparation.
- longevity-map – Web tool for exploring longevity-associated variants.
- stroke_prs & prs – Projects focusing on polygenic risk score calculations.
- gero-drugs-module – Early-stage module for drug-related genetic analysis.
- longevity-annotator – Archive of legacy modules for reference.
The majority of Just-DNA-Seq core developers also contribute to Longevity Genie, an open-source AI assistant for health, genetics, and longevity research.
- Website: just-dna.life
- Telegram: Join our Telegram group
- Preprint: Read our preprint on arXiv
The project is supported by:
- HEALES (Healthy Life Extension Society)
- IBIMA (Institute of Biomedical Informatics)
- Systems Biology of Aging Group
Whether you're a developer, researcher, or simply curious about your genetic blueprint, we welcome your contributions and feedback. Explore our repositories, join the discussion, and help us democratize personal genomics!
Unlock your genetic potential with transparency and confidence—welcome to Just-DNA-Seq!
