Haku, the Protein Structure Navigator.

This repository contains a Streamlit app called Haku, a collection of tools to navigate protein structures.

Features

• Find structures — Find all the structures of a protein using its UniProt AC.
• List proteins — List all the UniProt protein entries in the structure(s).
• View interactions — View all the ligand-protein interactions in the structure(s).
• Transmembrane annotations — Visualise transmembrane annotation on a protein structure.
• Similar structures — Find similar proteins with experimental structures.
• 3D viewer — Navigate protein structures in a 3D viewer (py3dmol / Mol*).
• Align sequences — Align sequences from PDB structure to UniProt protein sequence.
• Fetch SIFTS mappings — Fetch SIFTS mappings in DBREF format.

Input

• UniProt accession
• PDB code

Prerequisites

• Python 3.x
• Python libraries: streamlit, pandas, requests, pybiolib, matplotlib, aiohttp, tenacity, py3Dmol

Author

• Conny Yu – GitHub Profile
  Haku 2.3 September 2026 Haku 2.2 April 2026 Haku 2.0 October 2025