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NP-factor

First, estimating the task-based connectome for eight task conditions

CONN v16 batch with the shen-268 template

code for task-based connectome estimation: .\functions\xic_conn_batch.m

Second, predicting each of the eight psychiatric symptoms

code for brain-behavior prediction:.\functions\CPM-master

using the default threshold p = 0.01, linear regression

the significance level was set as 0.05/8/8 with Bonferroni correction

Thrid, we conducted the cross-disorder network for each task condition

the edge was both predictive to externalising and internalising symptoms

the longitudinal analysis for each group of cross-disorder network

Fourth, neurobiological characterisation of the NP factor

Brain anatomy, Cognitive behavior relevance

Fifth, genetic association of the NP factor

PRS of ADHD, MDD and IQ

SNP of rs6780942

code for gene expression:.\BrainSpan_NP_factor

Last, generalisation of the NP factor

ADHD-rest

ABCD-task

IMAGEN-rest

HCP-rest

Striatify-task

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  • MATLAB 100.0%