BraVE is a web application to explore the BIPMed genomic variant dataset
Initially, the table shows the first 10 variants ordered by genomic position. Change the number of showed variants at the top of the table to see more variants at same page (up to 100). At the bottom of the table, use the navigation buttons to move throughout the table.
When available, dbSNP column will present one or more links to NCBI dbSNP database.
Some variants may have more than one Alternative allele, in this case they are separated by comma.
Some variants have clinical characteristic. When available, they are provided on Clinical Significancecolumn.
They are many available values:
- Uncertain
- Not provided
- Benign
- Likely benign
- Likely pathogenic
- Pathogenic
- Drug response
- Histocompatibility
- Other
You can search for variants by typing or pasting:
- Gene symbols (
SCN1A,BRCA1) - Genomic range (
1:65000-70000,X:2600000-2800000) - Genomic position (
1:7737651,5:2747603) - dbSNP ID (
rs35735053,rs80357323)
The search system is case insensitive (scn1a will work) and ignores spaces (1 : 65000 -70000 will work too, except for dbSNP IDs).
It supports for multiple queries separated by new line or comma.
Example: SCN1A,1:65000-70000,1:7737651,rs35735053. The Shift+Enter is a key binding for Search Variants button.
Search results can be shared by copying the URL.
For example: http://bipmed.org/brave/index.html?queries=SCN1A%2C1:65000-70000%2C1:7737651%2Crs35735053.
This project is part of the Brazilian Initiative on Precision Medicine (BIPMed). and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN) institute, developed by the Laboratory of Biostatistics and Computational Biology (BCBLab) with funding from São Paulo Research Foundation (FAPESP).