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N3ha-Rao authored Dec 6, 2024
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Expand Up @@ -24,14 +24,6 @@ The NARAC dataset comprises a case-control study of Rheumatoid Arthritis with 86
4. **Polygenic Risk Scores (PRS)**:
- Calculated PRS using summary statistics from European and Asian populations to predict RA risk in the NARAC dataset.

## Key Findings

- **HLA Region Association**: The HLA region on chromosome 6 exhibited the most significant association with RA across all analyses.
- **Sex-Specific Differences**: Genetic associations were more pronounced in females, consistent with the higher prevalence of RA in women.
- **Population-Specific PRS Performance**:
- The European-derived PRS explained a substantial proportion of variance in RA status within the NARAC dataset.
- The Asian-derived PRS showed a weaker association, highlighting the importance of ancestry-matched PRS models.

## Citations

- Purcell S, Neale B, Todd-Brown K, et al. PLINK: A tool set for whole-genome association and population-based linkage analyses. *Am J Hum Genet*. 2007;81(3):559-575. [doi:10.1086/519795](https://doi.org/10.1086/519795)
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