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1. KG4SL KG4SL Public

   Synthetic lethality (SL) is a promising gold mine for the discovery of anti-cancer drug targets. KG4SL is the first graph neural network (GNN)-based model that uses knowledge graph for SL prediction.

   Python 31 12

2. SL_benchmark SL_benchmark Public

   Benchmarking study of machine learning methods for prediction of synthetic lethality

   Python 12 3

3. KR4SL KR4SL Public

   KR4SL is a machine learning method that leverages knowledge graph reasoning to predict synthetic lethality (SL) partners for a given primary gene, capturing the structural semantics of a knowledge …

   Python 4 4

4. PromptSL PromptSL Public

   PromptSL is a prompt-learning framework based on Biomedical Large Language Models (LLMs) for context-specific synthetic lethality prediction.

   Python

5. PiLSL PiLSL Public

   PiLSL is a pairwise interaction learning-based graph neural network (GNN) model for prediction of synthetic lethality (SL) as anti-cancer drug targets. It learns the representation of pairwise inte…

   Python 10 1

6. NSF4SL NSF4SL Public

   NSF4SL is a negative-sample-free model for prediction of synthetic lethality (SL) based on a self-supervised contrastive learning framework.

   Python 5 1