To apply bioinformatics skills to download, analyze, and interpret the sequence of the human TNF gene.
The Tumor Necrosis Factor (TNF) gene encodes a multifunctional proinflammatory cytokine that is a key regulator in immune response and inflammation.
Secreted primarily by macrophages in response to inflammatory stimuli, TNF interacts with its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR, to influence a wide range of biological processes.
TNFα can induce apoptotic or necrotic cell death in specific tumor cell lines and promote cell proliferation and differentiation under certain conditions.
It is also a potent pyrogen, capable of inducing fever by direct action or through the stimulation of interleukin-1 secretion.
Chronic overproduction of TNFα is associated with cachexia-like syndrome, particularly in cancer and severe infections.
Additionally, TNFα contributes to the development of insulin resistance in adipose tissue, linking it to obesity and diabetes.
https://atlasgeneticsoncology.org/gene/319/tnf-(tumor-necrosis-factor-(tnf-superfamily-member-2))