Centralized Resource for LLPS Prediction Tools

This curated list collects models developed to predict liquid-liquid phase separation (LLPS) propensity in proteins and related properties. For an interactive and browseable list, please visit: https://biogenies.info/llps-prediction-list/

1. PLAAC (2014): publication; web server; model repository.
2. R+Y (2015): publication.
3. CatGranule (2016): publication; web server.
4. PScore (2017): publication; web server; model repository.
5. PSPer (2019): publication; web server; model repository.
6. FuzDrop (2020): publication; web server.
7. Droppler (2021): publication; model repository.
8. PSAP (2021): publication; model repository.
9. DeePhase (2021): publication; web server; model repository.
10. ParSe 2.0 (2021): publication; web server; model repository.
11. MaGSeq (2022): publication; web server; model repository.
12. PASTA+PScore (2022): publication; model repository.
13. PSPredictor (2022): publication; web server.
14. LLPhyScore (2022): publication; model repository.
15. PhaSePred (2022): publication; web server.
16. Seq2Phase (2023): publication; model repository.
17. dSCOPE (2023): publication; web server.
18. PULPS (2023): publication; web server.
19. FLFB (2024): publication; web server; model repository.
20. PSPHunter (2024): publication; web server; model repository.
21. PSPire (2024): publication; model repository.
22. PICNIC (2024): publication; web server; model repository.
23. MolPhase (2024): publication; web server.
24. Opt_PredLLPs (2024): publication; model repository.
25. RNA-dependent LLPS Protein -Predictor (2024): publication; web server.
26. RNAPSEC models (2024): publication; web server; model repository.
27. CatGranule2.0 ROBOT (2025): publication; web server; model repository.
28. Prediction of Phase Transition in disordered proteins (2025): publication; web server; model repository.
29. PSTP-Scan (2025): publication; web server; model repository.