This is the official repository of the paper "Systems analysis of multiple diabetes-helminth cohorts reveals markers of disease-disease interaction" by Nilesh Subramanian, Philge Philip, Anuradha Rajamanickam, Nathella Pavan Kumar, Subash Babu, and Manikandan Narayanan.
This repository contains two sections:
- DDI pipeline
- Application of DDI pipeline on the helminth-diabetes dataset
Copyright 2023 BIRDS Group, IIT Madras
DDI-pipeline is a free pipeline: you can redistribute it and modify it under the terms of the GNU Lesser General Public License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version.
DDI-pipeline is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. Please take a look at the GNU Lesser General Public License for more details.
This section will provide information on how to run steps 2a and 2b in the Figure below. Steps 1 and 3 will vary between the datasets used (hence it is not provided here) and a detailed methodology on the same is given in our paper.
The DDI Pipeline folder has scripts, read me file to navigate through this section.
The Application on the helminth-diabetes dataset provides details on how to run the code to reproduce the Main Figures, Supplementary Figures, and Supplementary Tables from our paper.