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38 changes: 38 additions & 0 deletions participants/thyroid-cancer.md
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---
title: Thyroid Cancer Research Group, The University of Sydney
description:
toc: false
type: ABLeS Participant
---

## Project title

Applying single cell RNA sequencing to understand the immune landscape of thyroid cancer, with the goal of identifying therapeutic targets and biomarkers.

## Collaborators and funding

- Thyroid Cancer Research Group, Faculty of Medicine and Health, University of Sydney
- Kolling Institute of Medical Research
- Sydney Informatics Hub, University of Sydney

## Contact(s)

- Dr Martyn Bullock <martyn.bullock@sydney.edu.au>
- Dr Georgie Samaha <georgina.samaha@sydney.edu.au>
- Mr Frederick Jaya <frederick.jaya@sydney.edu.au>

## Project description and aims

Understanding the immune composition of thyroid tumours is critical for identifying novel therapeutic targets and predictive biomarkers. Leveraging single-cell RNA sequencing, this study will profile the tumour immune microenvironment at high resolution, enabling the discovery of cell-type-specific expression patterns and pathway dysregulation.

This project will be implemented on NCI's Gadi HPC, leveraging the open source [nf-core/scrnaseq](https://nf-co.re/scrnaseq) pipeline, and will produce public interactive notebooks for quality control, cell type annotation, differential expression, and biomarker discovery.

## How is ABLeS supporting this work?

This work is supported through the production bioinformatics scheme provided by ABLeS. The support includes and 10 KSUs per quarter.

## Expected outputs enabled by participation in ABLeS

A public scalable computational workflow and analytical notebooks for single-cell RNA sequencing in cancer cohorts that can be deployed on NCI Gadi.

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