diff --git a/demos/common.smk b/demos/common.smk
index 5929ad96..1ff89474 100644
--- a/demos/common.smk
+++ b/demos/common.smk
@@ -1,8 +1,17 @@
+import platform
 from pathlib import Path
+import os
+
+# Check if this is running on O2
+IS_O2 = (platform.system() == "Linux")
+
+if IS_O2:
+  O2_USER = os.environ["USER"]
+  O2_SCRATCH_DIR = f"/n/scratch/users/{O2_USER[0]}/{O2_USER}/vitessce-python/demos"
 
 # Directory / file constants
 SRC_DIR = Path("src")
-DATA_DIR = Path("data")
+DATA_DIR = Path("data" if not IS_O2 else O2_SCRATCH_DIR)
 RAW_DIR = DATA_DIR / "raw"
 PROCESSED_DIR = DATA_DIR / "processed"
 
diff --git a/demos/salcher-2022/Snakefile b/demos/salcher-2022/Snakefile
new file mode 100644
index 00000000..8b4b783f
--- /dev/null
+++ b/demos/salcher-2022/Snakefile
@@ -0,0 +1,36 @@
+include: "../common.smk"
+configfile: "config.yml"
+
+# May need to get new URLs from https://cellxgene.cziscience.com/collections/edb893ee-4066-4128-9aec-5eb2b03f8287
+
+# The single-cell lung cancer atlas (LuCA) -- extended atlas
+H5AD_URL = "https://datasets.cellxgene.cziscience.com/6e5e887d-96f7-40af-908c-9b4fc5057ef9.h5ad"
+
+rule all:
+    input:
+        [ (PROCESSED_DIR / f) for f in config['output'] ]
+
+rule convert_to_zarr:
+    input:
+        (RAW_DIR / "6e5e887d-96f7-40af-908c-9b4fc5057ef9.h5ad")
+    output:
+        directory(PROCESSED_DIR / "salcher_2022_extended.h5ad.zarr")
+    params:
+        script=(SRC_DIR / "convert_to_zarr.py")
+    shell:
+        '''
+        python {params.script} \
+            -i {input} \
+            -o {output}
+        '''
+
+# Download raw h5ad file.
+rule download_adata:
+    output:
+        (RAW_DIR / "6e5e887d-96f7-40af-908c-9b4fc5057ef9.h5ad")
+    params:
+        file_url=H5AD_URL
+    shell:
+        '''
+        curl -L --retry 999 --retry-delay 3 -C - -o {output} "{params.file_url}"
+        '''
diff --git a/demos/salcher-2022/config.yml b/demos/salcher-2022/config.yml
new file mode 100644
index 00000000..674fa553
--- /dev/null
+++ b/demos/salcher-2022/config.yml
@@ -0,0 +1,2 @@
+output:
+- salcher_2022_extended.h5ad.zarr
\ No newline at end of file
diff --git a/demos/salcher-2022/src/convert_to_zarr.py b/demos/salcher-2022/src/convert_to_zarr.py
new file mode 100644
index 00000000..37be86e6
--- /dev/null
+++ b/demos/salcher-2022/src/convert_to_zarr.py
@@ -0,0 +1,70 @@
+import argparse
+from anndata import read_h5ad
+import scipy
+import numpy as np
+import pandas as pd
+import platform
+import os
+import zarr
+import math
+
+def convert_h5ad_to_zarr(input_path, output_path):
+    adata = read_h5ad(input_path)
+
+    # Clear X so that we can write it ourselves manually
+    X = adata.X #.copy()
+    
+    adata.X = None
+    adata.write_zarr(output_path)
+
+    assert isinstance(X, scipy.sparse.spmatrix)
+
+    print(output_path)
+
+    store = zarr.DirectoryStore(output_path)
+    z = zarr.zeros(shape=X.shape, chunks=(X.shape[0], 10), dtype=X.dtype, store = store, path = "/X", overwrite=True)
+
+    chunk_shape = (10000, 10000)
+    x_chunks = math.ceil(X.shape[0] / chunk_shape[0])
+    y_chunks = math.ceil(X.shape[1] / chunk_shape[1])
+
+
+    for i in range(x_chunks):
+        for j in range(y_chunks):
+            x_start = i * chunk_shape[0]
+            x_end = min((i + 1) * chunk_shape[0], X.shape[0])
+            y_start = j * chunk_shape[1]
+            y_end = min((j + 1) * chunk_shape[1], X.shape[1])
+
+            X_chunk = X[x_start:x_end, y_start:y_end].tocoo(copy=False)
+            z.set_coordinate_selection(
+                # Add x_start and y_start as offsets to the row/chunk coordinates
+                ([cx+x_start for cx in X_chunk.row], [cy+y_start for cy in X_chunk.col]),
+                X_chunk.data
+            )
+
+    print("done")
+
+if __name__ == '__main__':
+    # Argparse
+    parser = argparse.ArgumentParser()
+    parser.add_argument(
+        '-i',
+        '--input',
+        type=str,
+        required=True,
+        help='Input H5AD file'
+    )
+    parser.add_argument(
+        '-o',
+        '--output',
+        type=str,
+        required=True,
+        help='Output Zarr store'
+    )
+    args = parser.parse_args()
+
+    convert_h5ad_to_zarr(
+        args.input,
+        args.output,
+    )
diff --git a/demos/sikkema-2023/Snakefile b/demos/sikkema-2023/Snakefile
new file mode 100644
index 00000000..c3551bbf
--- /dev/null
+++ b/demos/sikkema-2023/Snakefile
@@ -0,0 +1,36 @@
+include: "../common.smk"
+configfile: "config.yml"
+
+# May need to get new URLs from https://cellxgene.cziscience.com/collections/edb893ee-4066-4128-9aec-5eb2b03f8287
+
+# The single-cell lung cancer atlas (LuCA) -- extended atlas
+H5AD_URL = "https://datasets.cellxgene.cziscience.com/3ab47484-a3eb-4f6a-beea-670e1a8fc1e8.h5ad"
+
+rule all:
+    input:
+        [ (PROCESSED_DIR / f) for f in config['output'] ]
+
+rule convert_to_zarr:
+    input:
+        (RAW_DIR / "3ab47484-a3eb-4f6a-beea-670e1a8fc1e8.h5ad")
+    output:
+        directory(PROCESSED_DIR / "sikkema_2023_full.h5ad.zarr")
+    params:
+        script=(SRC_DIR / "convert_to_zarr.py")
+    shell:
+        '''
+        python {params.script} \
+            -i {input} \
+            -o {output}
+        '''
+
+# Download raw h5ad file.
+rule download_adata:
+    output:
+        (RAW_DIR / "3ab47484-a3eb-4f6a-beea-670e1a8fc1e8.h5ad")
+    params:
+        file_url=H5AD_URL
+    shell:
+        '''
+        curl -L --retry 999 --retry-delay 3 -C - -o {output} "{params.file_url}"
+        '''
diff --git a/demos/sikkema-2023/config.yml b/demos/sikkema-2023/config.yml
new file mode 100644
index 00000000..baeb72df
--- /dev/null
+++ b/demos/sikkema-2023/config.yml
@@ -0,0 +1,2 @@
+output:
+- sikkema_2023_full.h5ad.zarr
\ No newline at end of file
diff --git a/demos/sikkema-2023/src/convert_to_zarr.py b/demos/sikkema-2023/src/convert_to_zarr.py
new file mode 100644
index 00000000..aba2a980
--- /dev/null
+++ b/demos/sikkema-2023/src/convert_to_zarr.py
@@ -0,0 +1,41 @@
+import argparse
+from anndata import read_h5ad
+from scipy import sparse
+from vitessce.data_utils import (
+    to_uint8,
+)
+
+
+def convert_h5ad_to_zarr(input_path, output_path):
+    adata = read_h5ad(input_path)
+
+    adata.layers['X_uint8'] = to_uint8(adata.X, norm_along="var")
+
+    # Vitessce plays nicely with csc matrices
+    # TODO: automate conversion to csc in optimize_adata function
+    if isinstance(adata.X, sparse.spmatrix):
+        adata.X = adata.X.tocsc()
+    adata.write_zarr(output_path, chunks=[adata.shape[0], 10])
+
+
+if __name__ == '__main__':
+    parser = argparse.ArgumentParser()
+    parser.add_argument(
+        '-i',
+        '--input',
+        type=str,
+        required=True,
+        help='Input H5AD file'
+    )
+    parser.add_argument(
+        '-o',
+        '--output',
+        type=str,
+        required=True,
+        help='Output Zarr store'
+    )
+    args = parser.parse_args()
+    convert_h5ad_to_zarr(
+        args.input,
+        args.output
+    )
diff --git a/demos/spatialdata-2024/Snakefile b/demos/spatialdata-2024/Snakefile
new file mode 100644
index 00000000..7f4d9a16
--- /dev/null
+++ b/demos/spatialdata-2024/Snakefile
@@ -0,0 +1,35 @@
+
+include: "../common.smk"
+configfile: "config.yml"
+
+BASE_URL = "https://s3.embl.de/spatialdata/spatialdata-sandbox/{dataset}.zip"
+
+
+rule all:
+    input:
+        [ (PROCESSED_DIR / f) for f in config['output'] ]
+
+
+# Unzip the downloaded zip files
+rule unzip_file:
+    input:
+        (RAW_DIR / "{dataset}.zip")
+    output:
+        directory(PROCESSED_DIR / "{dataset}.zarr")
+    shell:
+        """
+        mkdir -p {RAW_DIR}/{wildcards.dataset} &&\
+        unzip {input} -d {RAW_DIR}/{wildcards.dataset} &&\
+        mv {RAW_DIR}/{wildcards.dataset}/data.zarr {PROCESSED_DIR}/{wildcards.dataset}.zarr
+        """
+
+# Download visium .zip file containing single-cell data.
+rule download_data:
+    output:
+        (RAW_DIR / "{dataset}.zip")
+    params:
+        file_url=BASE_URL
+    shell:
+        '''
+        curl -L -o {output} {params.file_url}
+        '''
\ No newline at end of file
diff --git a/demos/spatialdata-2024/config.yml b/demos/spatialdata-2024/config.yml
new file mode 100644
index 00000000..4f75ebc2
--- /dev/null
+++ b/demos/spatialdata-2024/config.yml
@@ -0,0 +1,10 @@
+output:
+- toy.zarr
+- visium_hd_3.0.0_io.zarr
+- visium_associated_xenium_io.zarr
+- xenium_rep1_io.zarr
+- xenium_rep2_io.zarr
+- mcmicro_io.zarr
+- merfish.zarr
+- mibitof.zarr
+- steinbock_io.zarr
\ No newline at end of file