Revise B cell slides

Author: sarahCobey

bcells/images/cohort_ve.png

@@ -77,7 +77,6 @@ <h3>Structure of a B cell receptor</h3>
 					<h3>Origins of B cell receptor diversity</h3>
 					<p>VDJ recombination
 					<p>Affinity maturation
-					
 				</section>
 
 				<section>
@@ -134,6 +133,16 @@ <h3>Dynamics in one GC</h3>
 						</div>
 				</section>
 
+                <section>
+                    <h3>Ab feedback may diversify the repertoire</h3>
+                    <img class="stretch" src="images/em_div.png">
+                        <div class="citation">
+                            <a href="http://cobeylab.uchicago.edu/publications">
+                                Childs et al. 2015
+                            </a>
+                        </div>
+                        </section>
+                
                 <section>
                     <h3>GC B cells evolve</h3>
                     <img class="stretch" src="images/gc_micro.png">
@@ -176,7 +185,7 @@ <h3>GCs produce plasma and memory cells</h3>
 				</section>
 
 				<section>
-					<h3>Memory cells can evolve further</h3>
+					<h3>(Can?) Memory cells evolve further (?)</h3>
 					<img src="images/andrews_memory.jpg" style="width: 70%; height: 70%;">
 						<div class="citation">
 							<a href="http://stm.sciencemag.org/content/7/316/316ra192">
@@ -185,17 +194,6 @@ <h3>Memory cells can evolve further</h3>
 						</div>
 						</section>
 
-				
-				<section>
-					<h3>Ab feedback may diversify the repertoire</h3>
-					<img class="stretch" src="images/em_div.png">
-						<div class="citation">
-							<a href="http://cobeylab.uchicago.edu/publications">
-								Childs et al. 2015
-							</a>
-						</div>
-				</section>
-				
 				<section>
 					<h3>Clones can be long-lived</h3>
 					<img class="stretch" src="images/ch103.png">
@@ -227,9 +225,9 @@ <h3>Broadly neutralizing antibodies to flu elusive</h3>
 				</section>
 
 				<section data-background="#99CCFF">
-					<p>Why do some people develop broadly neutralizing antibodies?</p>
-					<p>Can we induce them in everyone?
-					<p>Will they dominate?
+					<p>Why do some people develop more bnAbs?
+					<p>Can we induce high levels in everyone?
+					<p>How can we guarantee they will dominate?
 				</section>
 
 				<section>
@@ -371,6 +369,7 @@ <h3>Early infections affect vaccine response</h3>
                             </a>
                         </div>
                         </section>
+            
 
 				<section>
 					<h3>Response to 2009 H1N1 vaccine</h3>
@@ -413,15 +412,15 @@ <h3>Stalk antibodies are more polyreactive</h3>
 						</section>
 
 				<section data-background="#99CCFF">
-					<h3>Potential factors influencing specific antibody responses</h3>
+					<h3>What determines Ab immunodominance?</h3>
 					<p>Host genotype
 					<p>Order (Age?) of infection
 					<p>Immunogenicity
 					<p>Autoreactivity
 				</section>
 
                 <section>
-                    <h3>In U.S., flu vaccine coverage is high</h3>
+                    <h3>In U.S., flu vaccine coverage is high(-ish)</h3>
                     <img src="images/vaccine_coverage.png" style="width: 60%; height: 60%;">
                     <div class="citation">
                         <a href="https://www.cdc.gov/flu/fluvaxview/coverage-1516estimates.htm">
@@ -431,7 +430,7 @@ <h3>In U.S., flu vaccine coverage is high</h3>
                 </section>
 
                 <section>
-                    <h3>In RCT, vaccine provides high indirect protection</h3>
+                    <h3>In RCT, vaccine provides indirect protection</h3>
                     <img src="images/hutterite.png" style="width: 90%; height: 90%;">
                         <div class="citation">
                             <a href="http://jamanetwork.com/journals/jama/fullarticle/185509">
@@ -471,6 +470,16 @@ <h3>Sin diminishes egg effects in 2012-2013?</h3>
                         </div>
                 </section>
 
+                <section>
+                    <h3>Vaccine effectiveness tracks cohorts</h3>
+                    <img src="images/cohort_ve.png" style="width: 60%; height: 60%;">
+                        <div class="citation">
+                            <a href="https://www.medrxiv.org/content/10.1101/19001875v1">
+                                Arevalo et al. 2019
+                            </a>
+                        </div>
+                        </section>
+                
                 <section>
                     <h3>Another curiosity: low VE in repeat vaccinees</h3>
                     <img src="images/mclean.jpg" style="width: 90%; height: 90%;">