diff --git a/.changeset/sour-eggs-give.md b/.changeset/sour-eggs-give.md
new file mode 100644
index 0000000000..6fe64e887c
--- /dev/null
+++ b/.changeset/sour-eggs-give.md
@@ -0,0 +1,5 @@
+---
+"@react-router/dev": patch
+---
+
+Fix "Status message is not supported by HTTP/2" error during dev when using HTTPS
diff --git a/contributors.yml b/contributors.yml
index 46fd53bfa9..73053809c5 100644
--- a/contributors.yml
+++ b/contributors.yml
@@ -145,6 +145,7 @@
 - ivanjonas
 - Ivanrenes
 - JackPriceBurns
+- jacob-briscoe
 - jacob-ebey
 - JaffParker
 - jakkku
diff --git a/packages/react-router-dev/vite/node-adapter.ts b/packages/react-router-dev/vite/node-adapter.ts
index 8803e34ce1..8f2bc29b78 100644
--- a/packages/react-router-dev/vite/node-adapter.ts
+++ b/packages/react-router-dev/vite/node-adapter.ts
@@ -86,7 +86,12 @@ export function fromNodeRequest(
 // https://github.com/solidjs/solid-start/blob/7398163869b489cce503c167e284891cf51a6613/packages/start/node/fetch.js#L162-L185
 export async function toNodeRequest(res: Response, nodeRes: ServerResponse) {
   nodeRes.statusCode = res.status;
-  nodeRes.statusMessage = res.statusText;
+
+  // HTTP/2 doesn't support status messages
+  // https://datatracker.ietf.org/doc/html/rfc7540#section-8.1.2.4
+  if (!nodeRes.req || nodeRes.req.httpVersionMajor < 2) {
+    nodeRes.statusMessage = res.statusText;
+  }
 
   let cookiesStrings = [];