diff --git a/Cargo.lock b/Cargo.lock
index 6937828..625175a 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -131,6 +131,12 @@ dependencies = [
  "windows-sys 0.59.0",
 ]
 
+[[package]]
+name = "anyhow"
+version = "1.0.102"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "7f202df86484c868dbad7eaa557ef785d5c66295e41b460ef922eca0723b842c"
+
 [[package]]
 name = "arc-swap"
 version = "1.7.1"
@@ -307,6 +313,9 @@ dependencies = [
  "eyre",
  "lazy_static",
  "log",
+ "opentelemetry 0.30.0",
+ "opentelemetry-otlp",
+ "opentelemetry_sdk 0.30.0",
  "poem",
  "poem-openapi",
  "poem-openapi-derive",
@@ -321,6 +330,7 @@ dependencies = [
  "tantivy",
  "tempdir",
  "tokio",
+ "tracing-opentelemetry",
  "tracing-subscriber",
  "zstd-sys",
 ]
@@ -965,7 +975,7 @@ dependencies = [
  "bytes 0.5.6",
  "futures",
  "memchr",
- "pin-project",
+ "pin-project 0.4.30",
 ]
 
 [[package]]
@@ -989,6 +999,18 @@ dependencies = [
  "wasi",
 ]
 
+[[package]]
+name = "getrandom"
+version = "0.3.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "899def5c37c4fd7b2664648c28120ecec138e4d395b459e5ca34f9cce2dd77fd"
+dependencies = [
+ "cfg-if",
+ "libc",
+ "r-efi",
+ "wasip2",
+]
+
 [[package]]
 name = "ghash"
 version = "0.5.1"
@@ -1280,6 +1302,19 @@ dependencies = [
  "tower-service",
 ]
 
+[[package]]
+name = "hyper-timeout"
+version = "0.5.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "2b90d566bffbce6a75bd8b09a05aa8c2cb1fabb6cb348f8840c9e4c90a0d83b0"
+dependencies = [
+ "hyper 1.5.1",
+ "hyper-util",
+ "pin-project-lite",
+ "tokio",
+ "tower-service",
+]
+
 [[package]]
 name = "hyper-tls"
 version = "0.6.0"
@@ -1977,10 +2012,56 @@ dependencies = [
  "js-sys",
  "once_cell",
  "pin-project-lite",
- "thiserror",
+ "thiserror 1.0.69",
  "urlencoding",
 ]
 
+[[package]]
+name = "opentelemetry"
+version = "0.30.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "aaf416e4cb72756655126f7dd7bb0af49c674f4c1b9903e80c009e0c37e552e6"
+dependencies = [
+ "futures-core",
+ "futures-sink",
+ "js-sys",
+ "pin-project-lite",
+ "thiserror 2.0.18",
+ "tracing",
+]
+
+[[package]]
+name = "opentelemetry-http"
+version = "0.30.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "50f6639e842a97dbea8886e3439710ae463120091e2e064518ba8e716e6ac36d"
+dependencies = [
+ "async-trait",
+ "bytes 1.9.0",
+ "http 1.2.0",
+ "opentelemetry 0.30.0",
+ "reqwest",
+]
+
+[[package]]
+name = "opentelemetry-otlp"
+version = "0.30.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "dbee664a43e07615731afc539ca60c6d9f1a9425e25ca09c57bc36c87c55852b"
+dependencies = [
+ "http 1.2.0",
+ "opentelemetry 0.30.0",
+ "opentelemetry-http",
+ "opentelemetry-proto",
+ "opentelemetry_sdk 0.30.0",
+ "prost",
+ "reqwest",
+ "thiserror 2.0.18",
+ "tokio",
+ "tonic",
+ "tracing",
+]
+
 [[package]]
 name = "opentelemetry-prometheus"
 version = "0.14.1"
@@ -1988,12 +2069,24 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "6f8f082da115b0dcb250829e3ed0b8792b8f963a1ad42466e48422fbe6a079bd"
 dependencies = [
  "once_cell",
- "opentelemetry",
- "opentelemetry_sdk",
+ "opentelemetry 0.21.0",
+ "opentelemetry_sdk 0.21.2",
  "prometheus",
  "protobuf",
 ]
 
+[[package]]
+name = "opentelemetry-proto"
+version = "0.30.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "2e046fd7660710fe5a05e8748e70d9058dc15c94ba914e7c4faa7c728f0e8ddc"
+dependencies = [
+ "opentelemetry 0.30.0",
+ "opentelemetry_sdk 0.30.0",
+ "prost",
+ "tonic",
+]
+
 [[package]]
 name = "opentelemetry_sdk"
 version = "0.21.2"
@@ -2006,9 +2099,27 @@ dependencies = [
  "futures-util",
  "glob",
  "once_cell",
- "opentelemetry",
+ "opentelemetry 0.21.0",
  "ordered-float",
- "thiserror",
+ "thiserror 1.0.69",
+]
+
+[[package]]
+name = "opentelemetry_sdk"
+version = "0.30.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "11f644aa9e5e31d11896e024305d7e3c98a88884d9f8919dbf37a9991bc47a4b"
+dependencies = [
+ "futures-channel",
+ "futures-executor",
+ "futures-util",
+ "opentelemetry 0.30.0",
+ "percent-encoding",
+ "rand 0.9.2",
+ "serde_json",
+ "thiserror 2.0.18",
+ "tokio",
+ "tokio-stream",
 ]
 
 [[package]]
@@ -2093,7 +2204,16 @@ version = "0.4.30"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "3ef0f924a5ee7ea9cbcea77529dba45f8a9ba9f622419fe3386ca581a3ae9d5a"
 dependencies = [
- "pin-project-internal",
+ "pin-project-internal 0.4.30",
+]
+
+[[package]]
+name = "pin-project"
+version = "1.1.11"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "f1749c7ed4bcaf4c3d0a3efc28538844fb29bcdd7d2b67b2be7e20ba861ff517"
+dependencies = [
+ "pin-project-internal 1.1.11",
 ]
 
 [[package]]
@@ -2107,6 +2227,17 @@ dependencies = [
  "syn 1.0.109",
 ]
 
+[[package]]
+name = "pin-project-internal"
+version = "1.1.11"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d9b20ed30f105399776b9c883e68e536ef602a16ae6f596d2c473591d6ad64c6"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn 2.0.90",
+]
+
 [[package]]
 name = "pin-project-lite"
 version = "0.2.15"
@@ -2142,7 +2273,7 @@ dependencies = [
  "mime",
  "multer",
  "nix",
- "opentelemetry",
+ "opentelemetry 0.21.0",
  "opentelemetry-prometheus",
  "parking_lot",
  "percent-encoding",
@@ -2159,7 +2290,7 @@ dependencies = [
  "smallvec",
  "sse-codec",
  "tempfile",
- "thiserror",
+ "thiserror 1.0.69",
  "time",
  "tokio",
  "tokio-stream",
@@ -2200,7 +2331,7 @@ dependencies = [
  "serde_json",
  "serde_urlencoded",
  "serde_yaml",
- "thiserror",
+ "thiserror 1.0.69",
  "tokio",
 ]
 
@@ -2219,7 +2350,7 @@ dependencies = [
  "quote",
  "regex",
  "syn 1.0.109",
- "thiserror",
+ "thiserror 1.0.69",
 ]
 
 [[package]]
@@ -2305,7 +2436,30 @@ dependencies = [
  "memchr",
  "parking_lot",
  "protobuf",
- "thiserror",
+ "thiserror 1.0.69",
+]
+
+[[package]]
+name = "prost"
+version = "0.13.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "2796faa41db3ec313a31f7624d9286acf277b52de526150b7e69f3debf891ee5"
+dependencies = [
+ "bytes 1.9.0",
+ "prost-derive",
+]
+
+[[package]]
+name = "prost-derive"
+version = "0.13.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8a56d757972c98b346a9b766e3f02746cde6dd1cd1d1d563472929fdd74bec4d"
+dependencies = [
+ "anyhow",
+ "itertools",
+ "proc-macro2",
+ "quote",
+ "syn 2.0.90",
 ]
 
 [[package]]
@@ -2343,6 +2497,12 @@ dependencies = [
  "proc-macro2",
 ]
 
+[[package]]
+name = "r-efi"
+version = "5.3.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "69cdb34c158ceb288df11e18b4bd39de994f6657d83847bdffdbd7f346754b0f"
+
 [[package]]
 name = "radium"
 version = "0.7.0"
@@ -2369,10 +2529,20 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "34af8d1a0e25924bc5b7c43c079c942339d8f0a8b57c39049bef581b46327404"
 dependencies = [
  "libc",
- "rand_chacha",
+ "rand_chacha 0.3.1",
  "rand_core 0.6.4",
 ]
 
+[[package]]
+name = "rand"
+version = "0.9.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "6db2770f06117d490610c7488547d543617b21bfa07796d7a12f6f1bd53850d1"
+dependencies = [
+ "rand_chacha 0.9.0",
+ "rand_core 0.9.5",
+]
+
 [[package]]
 name = "rand_chacha"
 version = "0.3.1"
@@ -2383,6 +2553,16 @@ dependencies = [
  "rand_core 0.6.4",
 ]
 
+[[package]]
+name = "rand_chacha"
+version = "0.9.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d3022b5f1df60f26e1ffddd6c66e8aa15de382ae63b3a0c1bfc0e4d3e3f325cb"
+dependencies = [
+ "ppv-lite86",
+ "rand_core 0.9.5",
+]
+
 [[package]]
 name = "rand_core"
 version = "0.3.1"
@@ -2404,7 +2584,16 @@ version = "0.6.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "ec0be4795e2f6a28069bec0b5ff3e2ac9bafc99e6a9a7dc3547996c5c816922c"
 dependencies = [
- "getrandom",
+ "getrandom 0.2.15",
+]
+
+[[package]]
+name = "rand_core"
+version = "0.9.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "76afc826de14238e6e8c374ddcc1fa19e374fd8dd986b0d2af0d02377261d83c"
+dependencies = [
+ "getrandom 0.3.4",
 ]
 
 [[package]]
@@ -2455,7 +2644,7 @@ dependencies = [
  "flate2",
  "log",
  "rdkit-sys",
- "thiserror",
+ "thiserror 1.0.69",
 ]
 
 [[package]]
@@ -2602,7 +2791,7 @@ checksum = "c17fa4cb658e3583423e915b9f3acc01cceaee1860e33d59ebae66adc3a2dc0d"
 dependencies = [
  "cc",
  "cfg-if",
- "getrandom",
+ "getrandom 0.2.15",
  "libc",
  "spin",
  "untrusted",
@@ -3041,7 +3230,7 @@ dependencies = [
  "tantivy-stacker",
  "tantivy-tokenizer-api",
  "tempfile",
- "thiserror",
+ "thiserror 1.0.69",
  "time",
  "uuid",
  "winapi",
@@ -3235,7 +3424,16 @@ version = "1.0.69"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "b6aaf5339b578ea85b50e080feb250a3e8ae8cfcdff9a461c9ec2904bc923f52"
 dependencies = [
- "thiserror-impl",
+ "thiserror-impl 1.0.69",
+]
+
+[[package]]
+name = "thiserror"
+version = "2.0.18"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "4288b5bcbc7920c07a1149a35cf9590a2aa808e0bc1eafaade0b80947865fbc4"
+dependencies = [
+ "thiserror-impl 2.0.18",
 ]
 
 [[package]]
@@ -3249,6 +3447,17 @@ dependencies = [
  "syn 2.0.90",
 ]
 
+[[package]]
+name = "thiserror-impl"
+version = "2.0.18"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "ebc4ee7f67670e9b64d05fa4253e753e016c6c95ff35b89b7941d6b856dec1d5"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn 2.0.90",
+]
+
 [[package]]
 name = "thread_local"
 version = "1.1.8"
@@ -3402,6 +3611,57 @@ dependencies = [
  "winnow",
 ]
 
+[[package]]
+name = "tonic"
+version = "0.13.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "7e581ba15a835f4d9ea06c55ab1bd4dce26fc53752c69a04aac00703bfb49ba9"
+dependencies = [
+ "async-trait",
+ "base64 0.22.1",
+ "bytes 1.9.0",
+ "http 1.2.0",
+ "http-body 1.0.1",
+ "http-body-util",
+ "hyper 1.5.1",
+ "hyper-timeout",
+ "hyper-util",
+ "percent-encoding",
+ "pin-project 1.1.11",
+ "prost",
+ "tokio",
+ "tokio-stream",
+ "tower",
+ "tower-layer",
+ "tower-service",
+ "tracing",
+]
+
+[[package]]
+name = "tower"
+version = "0.5.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "ebe5ef63511595f1344e2d5cfa636d973292adc0eec1f0ad45fae9f0851ab1d4"
+dependencies = [
+ "futures-core",
+ "futures-util",
+ "indexmap 2.7.0",
+ "pin-project-lite",
+ "slab",
+ "sync_wrapper",
+ "tokio",
+ "tokio-util",
+ "tower-layer",
+ "tower-service",
+ "tracing",
+]
+
+[[package]]
+name = "tower-layer"
+version = "0.3.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "121c2a6cda46980bb0fcd1647ffaf6cd3fc79a013de288782836f6df9c48780e"
+
 [[package]]
 name = "tower-service"
 version = "0.3.3"
@@ -3451,6 +3711,24 @@ dependencies = [
  "tracing-core",
 ]
 
+[[package]]
+name = "tracing-opentelemetry"
+version = "0.31.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "ddcf5959f39507d0d04d6413119c04f33b623f4f951ebcbdddddfad2d0623a9c"
+dependencies = [
+ "js-sys",
+ "once_cell",
+ "opentelemetry 0.30.0",
+ "opentelemetry_sdk 0.30.0",
+ "smallvec",
+ "tracing",
+ "tracing-core",
+ "tracing-log",
+ "tracing-subscriber",
+ "web-time",
+]
+
 [[package]]
 name = "tracing-subscriber"
 version = "0.3.19"
@@ -3571,7 +3849,7 @@ version = "1.11.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "f8c5f0a0af699448548ad1a2fbf920fb4bee257eae39953ba95cb84891a0446a"
 dependencies = [
- "getrandom",
+ "getrandom 0.2.15",
  "serde",
 ]
 
@@ -3608,6 +3886,15 @@ version = "0.11.0+wasi-snapshot-preview1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "9c8d87e72b64a3b4db28d11ce29237c246188f4f51057d65a7eab63b7987e423"
 
+[[package]]
+name = "wasip2"
+version = "1.0.2+wasi-0.2.9"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9517f9239f02c069db75e65f174b3da828fe5f5b945c4dd26bd25d89c03ebcf5"
+dependencies = [
+ "wit-bindgen",
+]
+
 [[package]]
 name = "wasm-bindgen"
 version = "0.2.99"
@@ -3685,6 +3972,16 @@ dependencies = [
  "wasm-bindgen",
 ]
 
+[[package]]
+name = "web-time"
+version = "1.1.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5a6580f308b1fad9207618087a65c04e7a10bc77e02c8e84e9b00dd4b12fa0bb"
+dependencies = [
+ "js-sys",
+ "wasm-bindgen",
+]
+
 [[package]]
 name = "which"
 version = "4.4.2"
@@ -3864,6 +4161,12 @@ dependencies = [
  "memchr",
 ]
 
+[[package]]
+name = "wit-bindgen"
+version = "0.51.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d7249219f66ced02969388cf2bb044a09756a083d0fab1e566056b04d9fbcaa5"
+
 [[package]]
 name = "write16"
 version = "1.0.0"
diff --git a/Cargo.toml b/Cargo.toml
index e8544a3..84e3434 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -30,7 +30,11 @@ serde = { version = "1", features = ["derive"] }
 serde_json = { version = "1" }
 tantivy = "0.22"
 tokio = { version = "1", features = ["full"] }
-tracing-subscriber = { version = "0.3", features = ["env-filter"] }
+tracing-subscriber = { version = "0.3", features = ["env-filter", "registry"] }
+opentelemetry = "0.30"
+opentelemetry_sdk = { version = "0.30", features = ["rt-tokio"] }
+opentelemetry-otlp = { version = "0.30", features = ["grpc-tonic"] }
+tracing-opentelemetry = "0.31"
 zstd-sys = "=2.0.9"
 
 [dev-dependencies]
diff --git a/src/main.rs b/src/main.rs
index 3d10a3f..262276c 100644
--- a/src/main.rs
+++ b/src/main.rs
@@ -2,16 +2,56 @@
 
 use cheminee::{command_line, rest_api};
 use clap::*;
+use tracing_subscriber::layer::SubscriberExt;
+use tracing_subscriber::util::SubscriberInitExt;
 
-#[tokio::main]
-async fn main() -> eyre::Result<()> {
-    if std::env::var_os("RUST_LOG").is_some() {
-        tracing_subscriber::fmt()
-            .with_env_filter(tracing_subscriber::EnvFilter::from_default_env())
-            .init();
+fn init_tracing() -> eyre::Result<Option<opentelemetry_sdk::trace::SdkTracerProvider>> {
+    let env_filter = if std::env::var_os("RUST_LOG").is_some() {
+        tracing_subscriber::EnvFilter::from_default_env()
+    } else {
+        tracing_subscriber::EnvFilter::new("info")
+    };
+
+    let fmt_layer = tracing_subscriber::fmt::layer();
+
+    let registry = tracing_subscriber::registry()
+        .with(env_filter)
+        .with(fmt_layer);
+
+    if let Ok(endpoint) = std::env::var("OTEL_EXPORTER_OTLP_ENDPOINT") {
+        log::info!("OpenTelemetry enabled, exporting to {}", endpoint);
+
+        let exporter = opentelemetry_otlp::SpanExporter::builder()
+            .with_tonic()
+            .build()?;
+
+        let tracer_provider = opentelemetry_sdk::trace::SdkTracerProvider::builder()
+            .with_batch_exporter(exporter)
+            .with_resource(
+                opentelemetry_sdk::Resource::builder()
+                    .with_service_name(
+                        std::env::var("OTEL_SERVICE_NAME")
+                            .unwrap_or_else(|_| "cheminee".to_string()),
+                    )
+                    .build(),
+            )
+            .build();
+
+        let otel_layer =
+            tracing_opentelemetry::layer().with_tracer(tracer_provider.tracer("cheminee"));
+
+        registry.with(otel_layer).init();
+
+        Ok(Some(tracer_provider))
     } else {
-        tracing_subscriber::fmt().with_env_filter("info").init();
+        registry.init();
+        Ok(None)
     }
+}
+
+#[tokio::main]
+async fn main() -> eyre::Result<()> {
+    let tracer_provider = init_tracing()?;
 
     let app = Command::new("cheminee")
         .subcommand_required(true)
@@ -81,5 +121,9 @@ async fn main() -> eyre::Result<()> {
 
     matches?;
 
+    if let Some(provider) = tracer_provider {
+        provider.shutdown()?;
+    }
+
     Ok(())
 }