diff --git a/tests/unit/rate_limiting/test_core.py b/tests/unit/rate_limiting/test_core.py
index 658a5e6ce8cc..7b4422ea39c6 100644
--- a/tests/unit/rate_limiting/test_core.py
+++ b/tests/unit/rate_limiting/test_core.py
@@ -16,9 +16,17 @@
 import redis
 
 from limits import storage
+from pyramid.httpexceptions import HTTPTooManyRequests
 
 from warehouse import rate_limiting
-from warehouse.rate_limiting import DummyRateLimiter, RateLimit, RateLimiter
+from warehouse.metrics.interfaces import IMetricsService
+from warehouse.rate_limiting import (
+    DummyRateLimiter,
+    IRateLimiter,
+    RateLimit,
+    RateLimiter,
+    ratelimit_tween_factory,
+)
 
 
 class TestRateLimiter:
@@ -175,14 +183,117 @@ def test_eq(self):
         assert RateLimit("1 per 5 minutes", identifiers=["foo"]) != object()
 
 
+class TestRateLimiterTween:
+    def test_ratelimit_tween(self):
+        response = pretend.stub(headers={})
+        handler = pretend.call_recorder(lambda request: response)
+        registry = pretend.stub()
+        tween = ratelimit_tween_factory(handler, registry)
+
+        metrics_service = pretend.stub(
+            increment=pretend.call_recorder(lambda *a, **kw: None)
+        )
+        ratelimiter_service = pretend.stub(
+            test=pretend.call_recorder(lambda a: True),
+            hit=pretend.call_recorder(lambda a: None),
+        )
+
+        request = pretend.stub(
+            remote_addr="192.0.2.1",
+            path="/project/foobar/",
+            find_service=pretend.call_recorder(
+                lambda *a, **kw: {
+                    IMetricsService: metrics_service,
+                    IRateLimiter: ratelimiter_service,
+                }[a[0]]
+            ),
+        )
+
+        assert tween(request) is response
+
+        assert metrics_service.increment.calls == []
+        assert ratelimiter_service.hit.calls == [pretend.call("192.0.2.1")]
+        assert ratelimiter_service.test.calls == [pretend.call("192.0.2.1")]
+
+    def test_ratelimiter_tween_blocking(self):
+        response = pretend.stub(headers={})
+        handler = pretend.call_recorder(lambda request: response)
+        registry = pretend.stub()
+        tween = ratelimit_tween_factory(handler, registry)
+
+        metrics_service = pretend.stub(
+            increment=pretend.call_recorder(lambda *a, **kw: None)
+        )
+        ratelimiter_service = pretend.stub(
+            test=pretend.call_recorder(lambda a: False),
+            hit=pretend.call_recorder(lambda a: None),
+        )
+
+        request = pretend.stub(
+            remote_addr="192.0.2.1",
+            path="/project/foobar/",
+            find_service=pretend.call_recorder(
+                lambda *a, **kw: {
+                    IMetricsService: metrics_service,
+                    IRateLimiter: ratelimiter_service,
+                }[a[0]]
+            ),
+        )
+
+        response = tween(request)
+        assert isinstance(response, HTTPTooManyRequests)
+        assert (
+            response.message
+            == "Your IP has issued too many requests reaching the PyPI backends."
+        )
+
+        assert metrics_service.increment.calls == [
+            pretend.call("warehouse.ratelimited", tags=["ratelimiter:ip.requests"])
+        ]
+        assert ratelimiter_service.test.calls == [pretend.call("192.0.2.1")]
+        assert ratelimiter_service.hit.calls == []
+
+
 def test_includeme():
     registry = {}
     config = pretend.stub(
         registry=pretend.stub(
-            settings={"ratelimit.url": "memory://"}, __setitem__=registry.__setitem__
-        )
+            settings={
+                "ratelimit.url": "memory://",
+                "warehouse.ip_requests_ratelimit_string": "1000 per second",
+            },
+            __setitem__=registry.__setitem__,
+        ),
+        register_service_factory=pretend.call_recorder(lambda *a, **kw: None),
+        add_tween=pretend.call_recorder(lambda *a, **kw: None),
+    )
+
+    rate_limiting.includeme(config)
+
+    assert config.register_service_factory.calls == [
+        pretend.call(RateLimit("1000 per second"), IRateLimiter, name="ip.requests")
+    ]
+    assert config.add_tween.calls == [
+        pretend.call("warehouse.rate_limiting.ratelimit_tween_factory")
+    ]
+    assert isinstance(registry["ratelimiter.storage"], storage.MemoryStorage)
+
+
+def test_includeme_no_ip_requests_ratelimit():
+    registry = {}
+    config = pretend.stub(
+        registry=pretend.stub(
+            settings={
+                "ratelimit.url": "memory://",
+            },
+            __setitem__=registry.__setitem__,
+        ),
+        register_service_factory=pretend.call_recorder(lambda *a, **kw: None),
+        add_tween=pretend.call_recorder(lambda *a, **kw: None),
     )
 
     rate_limiting.includeme(config)
 
+    assert config.register_service_factory.calls == []
+    assert config.add_tween.calls == []
     assert isinstance(registry["ratelimiter.storage"], storage.MemoryStorage)
diff --git a/warehouse/config.py b/warehouse/config.py
index 1014a1ca6dbe..13baae49ebc4 100644
--- a/warehouse/config.py
+++ b/warehouse/config.py
@@ -482,6 +482,11 @@ def configure(settings=None):
     maybe_set(settings, "helpscout.mailbox_id", "HELPSCOUT_WAREHOUSE_MAILBOX_ID")
 
     # Configure our ratelimiters
+    maybe_set(
+        settings,
+        "warehouse.ip_requests_ratelimit_string",
+        "IP_REQUESTS_RATE_LIMIT_STRING",
+    )
     maybe_set(
         settings,
         "warehouse.account.user_login_ratelimit_string",
diff --git a/warehouse/rate_limiting/__init__.py b/warehouse/rate_limiting/__init__.py
index d40dbe4bac1f..5b38270af3a4 100644
--- a/warehouse/rate_limiting/__init__.py
+++ b/warehouse/rate_limiting/__init__.py
@@ -21,6 +21,7 @@
 from limits.storage import storage_from_string
 from limits.strategies import MovingWindowRateLimiter
 from more_itertools import first_true
+from pyramid.httpexceptions import HTTPTooManyRequests
 from zope.interface import implementer
 
 from warehouse.metrics import IMetricsService
@@ -162,7 +163,37 @@ def __eq__(self, other):
         )
 
 
+def ratelimit_tween_factory(handler, registry):
+    def ratelimit_tween(request):
+        ratelimiter = request.find_service(
+            IRateLimiter, name="ip.requests", context=None
+        )
+        metrics = request.find_service(IMetricsService, context=None)
+
+        if not ratelimiter.test(request.remote_addr):
+            metrics.increment("warehouse.ratelimited", tags=["ratelimiter:ip.requests"])
+            return HTTPTooManyRequests(
+                "Your IP has issued too many requests reaching the PyPI backends."
+            )
+
+        ratelimiter.hit(request.remote_addr)
+
+        response = handler(request)
+        return response
+
+    return ratelimit_tween
+
+
 def includeme(config):
     config.registry["ratelimiter.storage"] = storage_from_string(
         config.registry.settings["ratelimit.url"]
     )
+
+    ip_requests_ratelimit_string = config.registry.settings.get(
+        "warehouse.ip_requests_ratelimit_string"
+    )
+    if ip_requests_ratelimit_string is not None:
+        config.register_service_factory(
+            RateLimit(ip_requests_ratelimit_string), IRateLimiter, name="ip.requests"
+        )
+        config.add_tween("warehouse.rate_limiting.ratelimit_tween_factory")