diff --git a/.CMake/alg_support.cmake b/.CMake/alg_support.cmake
index 7aedc6e7bb..c24ba64076 100644
--- a/.CMake/alg_support.cmake
+++ b/.CMake/alg_support.cmake
@@ -28,7 +28,7 @@ endif()
 endif()
 
 # BIKE is not supported on Windows and 32-bit ARM
-cmake_dependent_option(OQS_ENABLE_KEM_BIKE "Enable BIKE algorithm family" ON "NOT WIN32; NOT ARCH_ARM32v7" OFF)
+cmake_dependent_option(OQS_ENABLE_KEM_BIKE "Enable BIKE algorithm family" ON "NOT WIN32; NOT ARCH_ARM32v7; NOT ARCH_X86" OFF)
 cmake_dependent_option(OQS_ENABLE_KEM_bike_l1 "" ON "OQS_ENABLE_KEM_BIKE" OFF)
 cmake_dependent_option(OQS_ENABLE_KEM_bike_l3 "" ON "OQS_ENABLE_KEM_BIKE" OFF)
 
diff --git a/CMakeLists.txt b/CMakeLists.txt
index bcbad3befe..eb712a0d86 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -35,6 +35,12 @@ if(CMAKE_SYSTEM_PROCESSOR MATCHES "x86_64|amd64|AMD64")
     if(${OQS_DIST_BUILD})
         set(OQS_DIST_X86_64_BUILD ON)
     endif()
+elseif(CMAKE_SYSTEM_PROCESSOR MATCHES "i586|i686")
+    set(ARCH "i586")
+    set(ARCH_X86 ON)
+    if(${OQS_DIST_BUILD})
+        set(OQS_DIST_X86_BUILD ON)
+    endif()
 elseif(CMAKE_SYSTEM_PROCESSOR MATCHES "aarch64|arm64|arm64v8")
     set(ARCH "arm64v8")
     set(ARCH_ARM64v8 ON)
@@ -47,6 +53,12 @@ elseif(CMAKE_SYSTEM_PROCESSOR MATCHES "armel|armhf|armv7|arm32v7")
     if(${OQS_DIST_BUILD})
         set(OQS_DIST_ARM32v7_BUILD ON)
     endif()
+elseif(CMAKE_SYSTEM_PROCESSOR MATCHES "ppc64le")
+    set(ARCH "ppc64le")
+    set(ARCH_PPC64LE ON)
+    if(${OQS_DIST_BUILD})
+        set(OQS_DIST_PPC64LE_BUILD ON)
+    endif()
 elseif(OQS_PERMIT_UNSUPPORTED_ARCHITECTURE)
     message(WARNING "Unknown or unsupported processor: " ${CMAKE_SYSTEM_PROCESSOR})
     message(WARNING "Compilation on an unsupported processor should only be used for testing, as it may result an insecure configuration, for example due to variable-time instructions leaking secret information.")
diff --git a/src/common/common.c b/src/common/common.c
index fa4a991a34..4a89c9bb5d 100644
--- a/src/common/common.c
+++ b/src/common/common.c
@@ -65,6 +65,11 @@ static void set_available_cpu_extensions(void) {
 		cpu_ext_data[OQS_CPU_EXT_VPCLMULQDQ] = is_bit_set(leaf_7.ecx, 10);
 	}
 }
+#elif defined(OQS_DIST_X86_BUILD)
+static void set_available_cpu_extensions(void) {
+	/* mark that this function has been called */
+	cpu_ext_data[OQS_CPU_EXT_INIT] = 1;
+}
 #elif defined(OQS_DIST_ARM64v8_BUILD)
 #include <sys/auxv.h>
 #include <asm/hwcap.h>
@@ -103,6 +108,11 @@ static void set_available_cpu_extensions(void) {
 		cpu_ext_data[OQS_CPU_EXT_ARM_NEON] = 1;
 	}
 }
+#elif defined(OQS_DIST_PPC64LE_BUILD)
+static void set_available_cpu_extensions(void) {
+	/* mark that this function has been called */
+	cpu_ext_data[OQS_CPU_EXT_INIT] = 1;
+}
 #elif defined(OQS_DIST_BUILD)
 static void set_available_cpu_extensions(void) {
 }
diff --git a/src/kem/sike/CMakeLists.txt b/src/kem/sike/CMakeLists.txt
index a7a4afcd59..574f50dea4 100644
--- a/src/kem/sike/CMakeLists.txt
+++ b/src/kem/sike/CMakeLists.txt
@@ -81,6 +81,8 @@ if(OQS_ENABLE_KEM_sike_p434 OR
     add_library(sike OBJECT ${SRCS})
     if(ARCH STREQUAL "x86")
         target_compile_definitions(sike PRIVATE _GENERIC_ _X86_)
+    elseif(ARCH_X86)
+        target_compile_definitions(sike PRIVATE _GENERIC_ _X86_)
     elseif(ARCH_X86_64)
         target_compile_definitions(sike PRIVATE _AMD64_)
         if(OQS_USE_BMI2_INSTRUCTIONS)
@@ -124,6 +126,8 @@ if(OQS_ENABLE_KEM_sike_p434 OR
                 target_compile_definitions(sike PRIVATE USE_SIKEP751_ASM)
             endif()
         endif()
+    elseif(ARCH_PPC64LE)
+        target_compile_definitions(sike PRIVATE _GENERIC_ _PPC64LE_)
     endif()
 
     if(CMAKE_C_COMPILER_ID STREQUAL "GNU")
diff --git a/src/kem/sike/external/P434/P434_internal.h b/src/kem/sike/external/P434/P434_internal.h
index b7160db1a7..6c7f66c896 100644
--- a/src/kem/sike/external/P434/P434_internal.h
+++ b/src/kem/sike/external/P434/P434_internal.h
@@ -9,7 +9,7 @@
 
 #include "../config.h"
 
-#if (TARGET == TARGET_AMD64) || (TARGET == TARGET_ARM64) || (TARGET == TARGET_S390X)
+#if (TARGET == TARGET_AMD64) || (TARGET == TARGET_ARM64) || (TARGET == TARGET_S390X) || (TARGET == TARGET_PPC64LE)
 #define NWORDS_FIELD 7    // Number of words of a 434-bit field element
 #define p434_ZERO_WORDS 3 // Number of "0" digits in the least significant part of p434 + 1
 #elif (TARGET == TARGET_x86) || (TARGET == TARGET_ARM)
diff --git a/src/kem/sike/external/P503/P503_internal.h b/src/kem/sike/external/P503/P503_internal.h
index d754085f0f..3a9bb326a4 100644
--- a/src/kem/sike/external/P503/P503_internal.h
+++ b/src/kem/sike/external/P503/P503_internal.h
@@ -9,7 +9,7 @@
 
 #include "../config.h"
 
-#if (TARGET == TARGET_AMD64) || (TARGET == TARGET_ARM64) || (TARGET == TARGET_S390X)
+#if (TARGET == TARGET_AMD64) || (TARGET == TARGET_ARM64) || (TARGET == TARGET_S390X) || (TARGET == TARGET_PPC64LE)
 #define NWORDS_FIELD 8    // Number of words of a 503-bit field element
 #define p503_ZERO_WORDS 3 // Number of "0" digits in the least significant part of p503 + 1
 #elif (TARGET == TARGET_x86) || (TARGET == TARGET_ARM)
diff --git a/src/kem/sike/external/P610/P610_internal.h b/src/kem/sike/external/P610/P610_internal.h
index 8456d5db24..8a6a08fb4a 100644
--- a/src/kem/sike/external/P610/P610_internal.h
+++ b/src/kem/sike/external/P610/P610_internal.h
@@ -9,7 +9,7 @@
 
 #include "../config.h"
 
-#if (TARGET == TARGET_AMD64) || (TARGET == TARGET_ARM64) || (TARGET == TARGET_S390X)
+#if (TARGET == TARGET_AMD64) || (TARGET == TARGET_ARM64) || (TARGET == TARGET_S390X) || (TARGET == TARGET_PPC64LE)
 #define NWORDS_FIELD 10   // Number of words of a 610-bit field element
 #define p610_ZERO_WORDS 4 // Number of "0" digits in the least significant part of p610 + 1
 #elif (TARGET == TARGET_x86) || (TARGET == TARGET_ARM)
diff --git a/src/kem/sike/external/P751/P751_internal.h b/src/kem/sike/external/P751/P751_internal.h
index 9216994904..1f9f231f9e 100644
--- a/src/kem/sike/external/P751/P751_internal.h
+++ b/src/kem/sike/external/P751/P751_internal.h
@@ -9,7 +9,7 @@
 
 #include "../config.h"
 
-#if (TARGET == TARGET_AMD64) || (TARGET == TARGET_ARM64) || (TARGET == TARGET_S390X)
+#if (TARGET == TARGET_AMD64) || (TARGET == TARGET_ARM64) || (TARGET == TARGET_S390X) || (TARGET == TARGET_PPC64LE)
 #define NWORDS_FIELD 12   // Number of words of a 751-bit field element
 #define p751_ZERO_WORDS 5 // Number of "0" digits in the least significant part of p751 + 1
 #elif (TARGET == TARGET_x86) || (TARGET == TARGET_ARM)
diff --git a/src/kem/sike/external/config.h b/src/kem/sike/external/config.h
index 1ae39862de..591f1cd554 100644
--- a/src/kem/sike/external/config.h
+++ b/src/kem/sike/external/config.h
@@ -31,6 +31,7 @@
 #define TARGET_S390X 3
 #define TARGET_ARM 4
 #define TARGET_ARM64 5
+#define TARGET_PPC64LE 6
 
 #if defined(_AMD64_)
 #define TARGET TARGET_AMD64
@@ -62,6 +63,12 @@ typedef uint16_t hdigit_t; // Unsigned 16-bit digit
 #define LOG2RADIX 6
 typedef uint64_t digit_t;  // Unsigned 64-bit digit
 typedef uint32_t hdigit_t; // Unsigned 32-bit digit
+#elif defined(_PPC64LE_)
+#define TARGET TARGET_PPC64LE
+#define RADIX           64
+#define LOG2RADIX       6
+typedef uint64_t digit_t;  // Unsigned 64-bit digit
+typedef uint32_t hdigit_t; // Unsigned 32-bit digit
 #else
 #error-- "Unsupported ARCHITECTURE"
 #endif
diff --git a/src/oqsconfig.h.cmake b/src/oqsconfig.h.cmake
index 9678be6991..88c90b07c3 100644
--- a/src/oqsconfig.h.cmake
+++ b/src/oqsconfig.h.cmake
@@ -4,8 +4,10 @@
 #cmakedefine OQS_COMPILE_BUILD_TARGET "@OQS_COMPILE_BUILD_TARGET@"
 #cmakedefine OQS_DIST_BUILD 1
 #cmakedefine OQS_DIST_X86_64_BUILD 1
+#cmakedefine OQS_DIST_X86_BUILD 1
 #cmakedefine OQS_DIST_ARM64v8_BUILD 1
 #cmakedefine OQS_DIST_ARM32v7_BUILD 1
+#cmakedefine OQS_DIST_PPC64LE_BUILD 1
 #cmakedefine OQS_DEBUG_BUILD 1
 #cmakedefine ARCH_X86_64 1
 #cmakedefine ARCH_ARM64v8 1