diff --git a/synchronicity/exceptions.py b/synchronicity/exceptions.py
index 2b11a26..9f15709 100644
--- a/synchronicity/exceptions.py
+++ b/synchronicity/exceptions.py
@@ -1,6 +1,10 @@
 import asyncio
 
 
+class SynchronizerShutdown(Exception):
+    pass
+
+
 class UserCodeException(Exception):
     """This is used to wrap and unwrap exceptions in "user code".
 
diff --git a/synchronicity/synchronizer.py b/synchronicity/synchronizer.py
index 8ea3aa1..f35161c 100644
--- a/synchronicity/synchronizer.py
+++ b/synchronicity/synchronizer.py
@@ -1,6 +1,7 @@
 import asyncio
 import atexit
 import collections.abc
+import concurrent.futures
 import contextlib
 import functools
 import inspect
@@ -17,7 +18,7 @@
 
 from .async_wrap import wraps_by_interface
 from .callback import Callback
-from .exceptions import UserCodeException, unwrap_coro_exception, wrap_coro_exception
+from .exceptions import SynchronizerShutdown, UserCodeException, unwrap_coro_exception, wrap_coro_exception
 from .interface import Interface
 
 _BUILTIN_ASYNC_METHODS = {
@@ -100,6 +101,8 @@ def should_have_aio_interface(func):
 class Synchronizer:
     """Helps you offer a blocking (synchronous) interface to asynchronous code."""
 
+    _stopping: asyncio.Event
+
     def __init__(
         self,
         multiwrap_warning=False,
@@ -313,7 +316,15 @@ def _run_function_sync(self, coro, interface, original_func):
         coro = self._wrap_check_async_leakage(coro)
         loop = self._get_loop(start=True)
         fut = asyncio.run_coroutine_threadsafe(coro, loop)
-        value = fut.result()
+        try:
+            value = fut.result()
+        except concurrent.futures.CancelledError:
+            if not self._loop or self._stopping.is_set():
+                # this allows differentiate between wrapped code raising concurrent.futures.CancelledError
+                # and synchronicity itself raising it due to the event loop shutting down while waiting
+                # for the synchronizer.
+                raise SynchronizerShutdown()
+            raise
 
         if getattr(original_func, self._output_translation_attr, True):
             return self._translate_out(value, interface)
@@ -332,12 +343,18 @@ async def _run_function_async(self, coro, interface, original_func):
         coro = wrap_coro_exception(coro)
         coro = self._wrap_check_async_leakage(coro)
         loop = self._get_loop(start=True)
+
         if self._is_inside_loop():
             value = await coro
         else:
-            c_fut = asyncio.run_coroutine_threadsafe(coro, loop)
-            a_fut = asyncio.wrap_future(c_fut)
-            value = await a_fut
+            try:
+                c_fut = asyncio.run_coroutine_threadsafe(coro, loop)
+                a_fut = asyncio.wrap_future(c_fut)
+                value = await a_fut
+            except asyncio.CancelledError:
+                if not self._loop or self._stopping.is_set():
+                    raise SynchronizerShutdown()
+                raise
 
         if getattr(original_func, self._output_translation_attr, True):
             return self._translate_out(value, interface)
diff --git a/test/shutdown_test.py b/test/shutdown_test.py
index fadff2c..b81f50b 100644
--- a/test/shutdown_test.py
+++ b/test/shutdown_test.py
@@ -1,7 +1,14 @@
+import asyncio
 import os
+import pytest
 import signal
 import subprocess
 import sys
+import threading
+import time
+
+import synchronicity
+from synchronicity.exceptions import SynchronizerShutdown
 
 
 def test_shutdown():
@@ -21,3 +28,57 @@ def test_shutdown():
     assert p.stdout.readline() == b"exiting\n"
     stderr_content = p.stderr.read()
     assert b"Traceback" not in stderr_content
+
+
+def test_shutdown_raises_shutdown_error():
+    s = synchronicity.Synchronizer()
+
+    @s.create_blocking
+    async def wrapped():
+        await asyncio.sleep(10)
+
+    def shut_down_soon():
+        s._get_loop(start=True)  # ensure loop is running
+        time.sleep(0.1)
+        s._close_loop()
+
+    t = threading.Thread(target=shut_down_soon)
+    t.start()
+
+    with pytest.raises(SynchronizerShutdown):
+        wrapped()
+
+    t.join()
+
+
+@pytest.mark.asyncio
+async def test_shutdown_raises_shutdown_error_async():
+    s = synchronicity.Synchronizer()
+
+    @s.create_blocking
+    async def wrapped():
+        await asyncio.sleep(10)
+
+    @s.create_blocking
+    async def supercall():
+        try:
+            # loop-internal calls should propagate the CancelledError
+            return await wrapped.aio()
+        except asyncio.CancelledError:
+            raise  # expected
+        except BaseException:
+            raise Exception("asyncio.CancelledError is expected internally")
+
+    def shut_down_soon():
+        s._get_loop(start=True)  # ensure loop is running
+        time.sleep(0.1)
+        s._close_loop()
+
+    t = threading.Thread(target=shut_down_soon)
+    t.start()
+
+    with pytest.raises(SynchronizerShutdown):
+        # calls from outside of the synchronizer loop should get the SynchronizerShutdown
+        await supercall.aio()
+
+    t.join()