diff --git a/pkg/webhook/pod/validating/cluster_colocation_profile.go b/pkg/webhook/pod/validating/cluster_colocation_profile.go
index 53b6d0a09..5fae1a11f 100644
--- a/pkg/webhook/pod/validating/cluster_colocation_profile.go
+++ b/pkg/webhook/pod/validating/cluster_colocation_profile.go
@@ -57,6 +57,8 @@ func (h *PodValidatingHandler) clusterColocationProfileValidatingPod(ctx context
 	allErrs = append(allErrs, validateRequiredQoSClass(newPod)...)
 	allErrs = append(allErrs, forbidSpecialQoSClassAndPriorityClass(newPod, extension.QoSBE, extension.PriorityNone, extension.PriorityProd)...)
 	allErrs = append(allErrs, forbidSpecialQoSClassAndPriorityClass(newPod, extension.QoSLSR, extension.PriorityNone, extension.PriorityMid, extension.PriorityBatch, extension.PriorityFree)...)
+	allErrs = append(allErrs, forbidSpecialQoSClassAndPriorityClass(newPod, extension.QoSLSE, extension.PriorityNone, extension.PriorityMid, extension.PriorityBatch, extension.PriorityFree)...)
+	allErrs = append(allErrs, forbidSpecialQoSClassAndPriorityClass(newPod, extension.QoSSystem, extension.PriorityMid, extension.PriorityBatch, extension.PriorityFree)...)
 	allErrs = append(allErrs, validateResources(newPod)...)
 	err := allErrs.ToAggregate()
 	allowed := true
diff --git a/pkg/webhook/pod/validating/cluster_colocation_profile_test.go b/pkg/webhook/pod/validating/cluster_colocation_profile_test.go
index dc3221cdd..8d4a06888 100644
--- a/pkg/webhook/pod/validating/cluster_colocation_profile_test.go
+++ b/pkg/webhook/pod/validating/cluster_colocation_profile_test.go
@@ -383,6 +383,156 @@ func TestClusterColocationProfileValidatingPod(t *testing.T) {
 			},
 			wantAllowed: true,
 		},
+		{
+			name:      "forbidden QoS and priorityClass combination: LSE And batch",
+			operation: admissionv1.Create,
+			newPod: &corev1.Pod{
+				ObjectMeta: metav1.ObjectMeta{
+					Labels: map[string]string{
+						extension.LabelPodQoS: string(extension.QoSLSE),
+					},
+				},
+				Spec: corev1.PodSpec{
+					Priority: pointer.Int32(extension.PriorityBatchValueMax),
+					Containers: []corev1.Container{
+						{
+							Resources: corev1.ResourceRequirements{
+								Requests: corev1.ResourceList{
+									corev1.ResourceCPU: resource.MustParse("1"),
+								},
+							},
+						},
+					},
+				},
+			},
+			wantAllowed: false,
+			wantReason:  `Pod: Forbidden: koordinator.sh/qosClass=LSE and priorityClass=koord-batch cannot be used in combination`,
+		},
+		{
+			name:      "forbidden QoS and priorityClass combination: LSE And Mid",
+			operation: admissionv1.Create,
+			newPod: &corev1.Pod{
+				ObjectMeta: metav1.ObjectMeta{
+					Labels: map[string]string{
+						extension.LabelPodQoS: string(extension.QoSLSE),
+					},
+				},
+				Spec: corev1.PodSpec{
+					Priority: pointer.Int32(extension.PriorityMidValueMax),
+					Containers: []corev1.Container{
+						{
+							Resources: corev1.ResourceRequirements{
+								Requests: corev1.ResourceList{
+									corev1.ResourceCPU: resource.MustParse("1"),
+								},
+							},
+						},
+					},
+				},
+			},
+			wantAllowed: false,
+			wantReason:  `Pod: Forbidden: koordinator.sh/qosClass=LSE and priorityClass=koord-mid cannot be used in combination`,
+		},
+		{
+			name:      "forbidden QoS and priorityClass combination: LSE And free",
+			operation: admissionv1.Create,
+			newPod: &corev1.Pod{
+				ObjectMeta: metav1.ObjectMeta{
+					Labels: map[string]string{
+						extension.LabelPodQoS: string(extension.QoSLSE),
+					},
+				},
+				Spec: corev1.PodSpec{
+					Priority: pointer.Int32(extension.PriorityFreeValueMax),
+					Containers: []corev1.Container{
+						{
+							Resources: corev1.ResourceRequirements{
+								Requests: corev1.ResourceList{
+									corev1.ResourceCPU: resource.MustParse("1"),
+								},
+							},
+						},
+					},
+				},
+			},
+			wantAllowed: false,
+			wantReason:  `Pod: Forbidden: koordinator.sh/qosClass=LSE and priorityClass=koord-free cannot be used in combination`,
+		},
+		{
+			name:      "forbidden QoS and priorityClass combination: SYSTEM And batch",
+			operation: admissionv1.Create,
+			newPod: &corev1.Pod{
+				ObjectMeta: metav1.ObjectMeta{
+					Labels: map[string]string{
+						extension.LabelPodQoS: string(extension.QoSSystem),
+					},
+				},
+				Spec: corev1.PodSpec{
+					Priority: pointer.Int32(extension.PriorityBatchValueMax),
+					Containers: []corev1.Container{
+						{
+							Resources: corev1.ResourceRequirements{
+								Requests: corev1.ResourceList{
+									corev1.ResourceCPU: resource.MustParse("1"),
+								},
+							},
+						},
+					},
+				},
+			},
+			wantAllowed: false,
+			wantReason:  `Pod: Forbidden: koordinator.sh/qosClass=SYSTEM and priorityClass=koord-batch cannot be used in combination`,
+		},
+		{
+			name:      "forbidden QoS and priorityClass combination: SYSTEM And Mid",
+			operation: admissionv1.Create,
+			newPod: &corev1.Pod{
+				ObjectMeta: metav1.ObjectMeta{
+					Labels: map[string]string{
+						extension.LabelPodQoS: string(extension.QoSSystem),
+					},
+				},
+				Spec: corev1.PodSpec{
+					Priority: pointer.Int32(extension.PriorityMidValueMax),
+					Containers: []corev1.Container{
+						{
+							Resources: corev1.ResourceRequirements{
+								Requests: corev1.ResourceList{
+									corev1.ResourceCPU: resource.MustParse("1"),
+								},
+							},
+						},
+					},
+				},
+			},
+			wantAllowed: false,
+			wantReason:  `Pod: Forbidden: koordinator.sh/qosClass=SYSTEM and priorityClass=koord-mid cannot be used in combination`,
+		},
+		{
+			name:      "forbidden QoS and priorityClass combination: SYSTEM And free",
+			operation: admissionv1.Create,
+			newPod: &corev1.Pod{
+				ObjectMeta: metav1.ObjectMeta{
+					Labels: map[string]string{
+						extension.LabelPodQoS: string(extension.QoSSystem),
+					},
+				},
+				Spec: corev1.PodSpec{
+					Priority: pointer.Int32(extension.PriorityFreeValueMax),
+					Containers: []corev1.Container{
+						{
+							Resources: corev1.ResourceRequirements{
+								Requests: corev1.ResourceList{
+									corev1.ResourceCPU: resource.MustParse("1"),
+								},
+							},
+						},
+					},
+				},
+			},
+			wantAllowed: false,
+			wantReason:  `Pod: Forbidden: koordinator.sh/qosClass=SYSTEM and priorityClass=koord-free cannot be used in combination`,
+		},
 		{
 			name:      "forbidden resources - LSR And Prod: unset CPUs",
 			operation: admissionv1.Create,
@@ -443,6 +593,36 @@ func TestClusterColocationProfileValidatingPod(t *testing.T) {
 			wantAllowed: false,
 			wantReason:  `pod.spec.containers[*].resources.requests: Invalid value: "100m": the requested CPUs of LSR Pod must be integer`,
 		},
+		{
+			name:      "validate resources - LSE And Prod",
+			operation: admissionv1.Create,
+			newPod: &corev1.Pod{
+				ObjectMeta: metav1.ObjectMeta{
+					Labels: map[string]string{
+						extension.LabelPodQoS: string(extension.QoSLSE),
+					},
+				},
+				Spec: corev1.PodSpec{
+					Priority: pointer.Int32(extension.PriorityProdValueMax),
+					Containers: []corev1.Container{
+						{
+							Name: "test-container-skip",
+							Resources: corev1.ResourceRequirements{
+								Limits: corev1.ResourceList{
+									corev1.ResourceCPU:    resource.MustParse("1000m"),
+									corev1.ResourceMemory: resource.MustParse("4Gi"),
+								},
+								Requests: corev1.ResourceList{
+									corev1.ResourceCPU:    resource.MustParse("1000m"),
+									corev1.ResourceMemory: resource.MustParse("4Gi"),
+								},
+							},
+						},
+					},
+				},
+			},
+			wantAllowed: true,
+		},
 	}
 
 	for _, tt := range tests {