diff --git a/func_adl_uproot/transformer.py b/func_adl_uproot/transformer.py
index e723c32..00b5a38 100644
--- a/func_adl_uproot/transformer.py
+++ b/func_adl_uproot/transformer.py
@@ -8,6 +8,7 @@
 
 input_filenames_argument_name = 'input_filenames'
 tree_name_argument_name = 'tree_name'
+branch_filter_name = '_remove_not_interpretable'
 
 unary_op_dict = {ast.UAdd: '+', ast.USub: '-', ast.Invert: '~'}
 
@@ -437,7 +438,9 @@ def visit_Call(self, node):
                 + "(logging.getLogger(__name__).info('Using treename='"
                 + ' + repr(tree_name_to_use)),'
                 + ' uproot.dask({input_file: tree_name_to_use'
-                + ' for input_file in input_files}))[1])'
+                + ' for input_file in input_files}, filter_branch='
+                + branch_filter_name
+                + '))[1])'
                 + '('
                 + source_rep
                 + ', '
diff --git a/func_adl_uproot/translation.py b/func_adl_uproot/translation.py
index 0ed20f7..b9b21b5 100644
--- a/func_adl_uproot/translation.py
+++ b/func_adl_uproot/translation.py
@@ -3,7 +3,39 @@
 import qastle
 
 from .transformer import PythonSourceGeneratorTransformer
-from .transformer import input_filenames_argument_name, tree_name_argument_name
+from .transformer import branch_filter_name, input_filenames_argument_name, tree_name_argument_name
+
+# Adapted from https://github.com/CoffeaTeam/coffea/blob/v2024.4.0/src/coffea/util.py#L217-L248
+remove_not_interpretable_source = (
+    '    def '
+    + branch_filter_name
+    + '''(branch):
+        if isinstance(branch.interpretation, uproot.interpretation.identify.uproot.AsGrouped):
+            for name, interpretation in branch.interpretation.subbranches.items():
+                if isinstance(
+                        interpretation, uproot.interpretation.identify.UnknownInterpretation
+                    ):
+                    logging.getLogger(__name__).warning(
+                        f"Skipping {branch.name} as it is not interpretable by Uproot"
+                    )
+                    return False
+        if isinstance(branch.interpretation, uproot.interpretation.identify.UnknownInterpretation):
+            logging.getLogger(__name__).warning(
+                f"Skipping {branch.name} as it is not interpretable by Uproot"
+            )
+            return False
+        try:
+            _ = branch.interpretation.awkward_form(None)
+        except uproot.interpretation.objects.CannotBeAwkward:
+            logging.getLogger(__name__).warning(
+                f"Skipping {branch.name} as it cannot be represented as an Awkward array"
+            )
+            return False
+        else:
+            return True
+
+'''
+)
 
 
 def python_ast_to_python_source(python_ast):
@@ -26,7 +58,8 @@ def generate_python_source(ast, function_name='run_query'):
         + '=None):\n'
     )
     source += '    import functools, logging, numpy as np, dask_awkward as dak, uproot, vector\n'
-    source += '    vector.register_awkward()\n'
+    source += '    vector.register_awkward()\n\n'
+    source += remove_not_interpretable_source
     source += '    return ' + python_ast_to_python_source(python_ast) + '.compute()\n'
     return source