diff --git a/CHANGELOG.md b/CHANGELOG.md
index e564a70cbc..c5d9d8ed52 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -12,6 +12,10 @@
 
 - Add `enableNdkAppHangTracking` and `ndkAppHangTimeoutIntervalMillis` options to enable Android NDK app hang tracking ([#6548](https://github.com/getsentry/sentry-react-native/pull/6548))
 
+### Fixes
+
+- Fix Android fragment memory leak in `RNSentryReactFragmentLifecycleTracer` ([#6599](https://github.com/getsentry/sentry-react-native/pull/6599))
+
 ### Dependencies
 
 - Bump Android SDK from v8.52.0 to v8.53.0 ([#6586](https://github.com/getsentry/sentry-react-native/pull/6586))
diff --git a/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/rnsentryandroidtester/RNSentryReactFragmentLifecycleTracerTest.kt b/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/rnsentryandroidtester/RNSentryReactFragmentLifecycleTracerTest.kt
index d7599ea274..c636a60a54 100644
--- a/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/rnsentryandroidtester/RNSentryReactFragmentLifecycleTracerTest.kt
+++ b/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/rnsentryandroidtester/RNSentryReactFragmentLifecycleTracerTest.kt
@@ -41,6 +41,21 @@ class RNSentryReactFragmentLifecycleTracerTest {
         verify(mockEventDispatcher, times(1)).addListener(any())
     }
 
+    @Test
+    fun tracerRemovesListenerWhenFragmentViewDestroyed() {
+        val mockEventDispatcher = mock<EventDispatcher>()
+        val fragment = mock<ScreenStackFragment>()
+
+        val tracer = createSutWith()
+        mockUIManager(mockEventDispatcher)
+
+        callOnFragmentViewCreated(fragment, mockScreenViewWithReactContext(), tracer)
+        verify(mockEventDispatcher, times(1)).addListener(any())
+
+        callOnFragmentViewDestroyed(fragment, tracer)
+        verify(mockEventDispatcher, times(1)).removeListener(any())
+    }
+
     @Test
     fun tracerDoesNotAddListenerForGenericFragment() {
         val mockEventDispatcher = mock<EventDispatcher>()
@@ -87,8 +102,9 @@ class RNSentryReactFragmentLifecycleTracerTest {
     private fun callOnFragmentViewCreated(
         mockFragment: Fragment,
         mockView: View,
+        tracer: RNSentryReactFragmentLifecycleTracer = createSutWith(),
     ) {
-        createSutWith().onFragmentViewCreated(
+        tracer.onFragmentViewCreated(
             mock(),
             mockFragment,
             mockView,
@@ -96,6 +112,13 @@ class RNSentryReactFragmentLifecycleTracerTest {
         )
     }
 
+    private fun callOnFragmentViewDestroyed(
+        mockFragment: Fragment,
+        tracer: RNSentryReactFragmentLifecycleTracer = createSutWith(),
+    ) {
+        tracer.onFragmentViewDestroyed(mock(), mockFragment)
+    }
+
     private fun createSutWith(): RNSentryReactFragmentLifecycleTracer {
         val logger: ILogger = mock()
         val buildInfo = BuildInfoProvider(logger)
diff --git a/packages/core/android/src/main/java/io/sentry/react/RNSentryReactFragmentLifecycleTracer.java b/packages/core/android/src/main/java/io/sentry/react/RNSentryReactFragmentLifecycleTracer.java
index 4ee8700214..c8cbc4bc88 100644
--- a/packages/core/android/src/main/java/io/sentry/react/RNSentryReactFragmentLifecycleTracer.java
+++ b/packages/core/android/src/main/java/io/sentry/react/RNSentryReactFragmentLifecycleTracer.java
@@ -16,6 +16,8 @@
 import io.sentry.SentryLevel;
 import io.sentry.android.core.BuildInfoProvider;
 import io.sentry.android.core.internal.util.FirstDrawDoneListener;
+import java.util.HashMap;
+import java.util.Map;
 import org.jetbrains.annotations.NotNull;
 import org.jetbrains.annotations.Nullable;
 
@@ -24,6 +26,7 @@ public class RNSentryReactFragmentLifecycleTracer extends FragmentLifecycleCallb
   private @NotNull final BuildInfoProvider buildInfoProvider;
   private @NotNull final Runnable emitNewFrameEvent;
   private @NotNull final ILogger logger;
+  private final Map<Fragment, EventDispatcherListenerWrapper> listenerWrapperMap = new HashMap<>();
 
   public RNSentryReactFragmentLifecycleTracer(
       @NotNull BuildInfoProvider buildInfoProvider,
@@ -83,18 +86,40 @@ public void onFragmentViewCreated(
       return;
     }
 
-    final @NotNull Runnable emitNewFrameEvent = this.emitNewFrameEvent;
-    eventDispatcher.addListener(
-        new EventDispatcherListener() {
+    EventDispatcherListenerWrapper listenerWrapper =
+        new EventDispatcherListenerWrapper(eventDispatcher) {
           @Override
           public void onEventDispatch(Event event) {
             if ("com.swmansion.rnscreens.events.ScreenAppearEvent"
                 .equals(event.getClass().getCanonicalName())) {
-              eventDispatcher.removeListener(this);
+              this.dispatcher.removeListener(this);
+              listenerWrapperMap.remove(f);
               FirstDrawDoneListener.registerForNextDraw(v, emitNewFrameEvent, buildInfoProvider);
             }
           }
-        });
+        };
+
+    eventDispatcher.addListener(listenerWrapper);
+    listenerWrapperMap.put(f, listenerWrapper);
+  }
+
+  @Override
+  public void onFragmentViewDestroyed(@NonNull FragmentManager fm, @NonNull Fragment f) {
+    super.onFragmentViewDestroyed(fm, f);
+    EventDispatcherListenerWrapper listenerWrapper = listenerWrapperMap.get(f);
+    if (listenerWrapper != null && listenerWrapper.dispatcher != null) {
+      listenerWrapper.dispatcher.removeListener(listenerWrapper);
+      listenerWrapperMap.remove(f);
+    }
+  }
+
+  abstract static class EventDispatcherListenerWrapper implements EventDispatcherListener {
+
+    protected final EventDispatcher dispatcher;
+
+    public EventDispatcherListenerWrapper(EventDispatcher dispatcher) {
+      this.dispatcher = dispatcher;
+    }
   }
 
   private static @Nullable EventDispatcher getEventDispatcherForReactTag(