diff --git a/conda_smithy/configure_feedstock.py b/conda_smithy/configure_feedstock.py
index aba123d42..ef8c9f9c6 100644
--- a/conda_smithy/configure_feedstock.py
+++ b/conda_smithy/configure_feedstock.py
@@ -693,12 +693,63 @@ def _collapse_subpackage_variants(
 
     logger.debug("final used_key_values %s", pprint.pformat(used_key_values))
 
+    configs = break_up_top_level_values(top_level_loop_vars, used_key_values)
+
+    # return (configs, top_level_loop_vars)
+
     return (
-        break_up_top_level_values(top_level_loop_vars, used_key_values),
+        [
+            config
+            for config in configs
+            if not _is_config_skipped(config, top_level_loop_vars, list_of_metas)
+        ],
         top_level_loop_vars,
     )
 
 
+def _is_config_skipped(config, top_level_loop_vars, list_of_metas):
+    trimmed_config = {loop_var: config[loop_var] for loop_var in top_level_loop_vars}
+    logger.debug("checking config: %s", trimmed_config)
+    for i, meta in enumerate(list_of_metas):
+        trimmed_meta = {
+            loop_var: meta.config.variant.get(loop_var)
+            for loop_var in top_level_loop_vars
+        }
+        logger.debug("  checking in meta: %s", trimmed_meta)
+        for loop_var in top_level_loop_vars:
+            variant = meta.config.variant
+            if loop_var not in variant:
+                logger.debug(
+                    "    skipping meta because %s is not in meta variant", loop_var
+                )
+                break
+            if isinstance(variant[loop_var], (list, set)) and set(
+                config[loop_var]
+            ) - set(variant[loop_var]):
+                logger.debug(
+                    "    skipping meta because %s in meta variant is %s, but in config is %s",
+                    loop_var,
+                    variant[loop_var],
+                    config[loop_var],
+                )
+                break
+            if isinstance(variant[loop_var], (int, float, str)) and set(
+                config[loop_var]
+            ) - set([variant[loop_var]]):
+                logger.debug(
+                    "    skipping meta because %s in meta variant is %s and in config is %s",
+                    loop_var,
+                    [variant[loop_var]],
+                    config[loop_var],
+                )
+                break
+        else:
+            logger.debug("    FOUND! meta variant matches config")
+            return False
+    logger.debug("  SKIPPED!")
+    return True
+
+
 def _yaml_represent_ordereddict(yaml_representer, data):
     # represent_dict processes dict-likes with a .sort() method or plain iterables of key-value
     #     pairs. Only for the latter it never sorts and retains the order of the OrderedDict.
diff --git a/news/2434-skipped-matrix.rst b/news/2434-skipped-matrix.rst
new file mode 100644
index 000000000..f62da7153
--- /dev/null
+++ b/news/2434-skipped-matrix.rst
@@ -0,0 +1,23 @@
+**Added:**
+
+* <news item>
+
+**Changed:**
+
+* <news item>
+
+**Deprecated:**
+
+* <news item>
+
+**Removed:**
+
+* <news item>
+
+**Fixed:**
+
+* Fix configuration generation by respecting additive ``skip`` statements properly. (#1617 via #2434)
+
+**Security:**
+
+* <news item>
diff --git a/tests/recipes/skip_rerenders_ok/conda_build_config.yaml b/tests/recipes/skip_rerenders_ok/conda_build_config.yaml
new file mode 100644
index 000000000..35d40156a
--- /dev/null
+++ b/tests/recipes/skip_rerenders_ok/conda_build_config.yaml
@@ -0,0 +1,7 @@
+# https://github.com/conda-forge/conda-smithy/issues/1617
+mpi:
+  - openmpi
+  - nompi
+double:
+  - "no"
+  - "yes"
diff --git a/tests/recipes/skip_rerenders_ok/meta.yaml b/tests/recipes/skip_rerenders_ok/meta.yaml
new file mode 100644
index 000000000..5ccafcfcf
--- /dev/null
+++ b/tests/recipes/skip_rerenders_ok/meta.yaml
@@ -0,0 +1,11 @@
+package:
+  name: skip-rerenders-ok
+  version: 1.0
+
+build:
+  # Only build for linux so we get up-to 4 configs (as per the conda-build-config-file)
+  skip: true  # [not linux64]
+  # With this one skip, we remove one entry from the 2x2 matrix
+  skip: true  # [mpi == "nompi" and double == "yes"]
+
+about: {}
diff --git a/tests/test_cli.py b/tests/test_cli.py
index e4a8aa4a5..4b724b919 100644
--- a/tests/test_cli.py
+++ b/tests/test_cli.py
@@ -3,6 +3,7 @@
 import os
 import shutil
 import subprocess
+from pathlib import Path
 from textwrap import dedent
 
 import pytest
@@ -349,6 +350,39 @@ def test_render_variant_mismatches(testing_workdir):
         assert data["a"] == data["b"]
 
 
+def test_render_skipped_variants(testing_workdir):
+    """
+    Regression test for https://github.com/conda-forge/conda-smithy/issues/1617
+    """
+    parser = argparse.ArgumentParser()
+    subparser = parser.add_subparsers()
+    init_obj = cli.Init(subparser)
+    regen_obj = cli.Regenerate(subparser)
+    _thisdir = os.path.abspath(os.path.dirname(__file__))
+    recipe = os.path.join(_thisdir, "recipes", "skip_rerenders_ok")
+    feedstock_dir = os.path.join(testing_workdir, "test-skipped-variants-feedstock")
+    args = InitArgs(
+        recipe_directory=recipe,
+        feedstock_directory=feedstock_dir,
+        temporary_directory=os.path.join(recipe, "temp"),
+    )
+    init_obj(args)
+    args = RegenerateArgs(
+        feedstock_directory=feedstock_dir,
+        feedstock_config=None,
+        commit=False,
+        no_check_uptodate=True,
+        exclusive_config_file="recipe/conda_build_config.yaml",
+        check=False,
+        temporary_directory=os.path.join(recipe, "temp"),
+    )
+    regen_obj(args)
+
+    # We skip one config out of the 2x2 matrix, so we expect three configs
+    configs = list(Path(feedstock_dir, ".ci_support").glob("*.yaml"))
+    assert len(configs) == 3
+
+
 def test_render_readme_with_v1_recipe_name(testing_workdir):
     parser = argparse.ArgumentParser()
     subparser = parser.add_subparsers()