diff --git a/Configuration/StandardSequences/python/VtxSmeared.py b/Configuration/StandardSequences/python/VtxSmeared.py
index e9305be3931a2..7b7d72a167746 100644
--- a/Configuration/StandardSequences/python/VtxSmeared.py
+++ b/Configuration/StandardSequences/python/VtxSmeared.py
@@ -76,5 +76,6 @@
     'Realistic2024ppRefCollision' : 'IOMC.EventVertexGenerators.VtxSmearedRealistic2024ppRefCollision_cfi',
     'Realistic2024PbPbCollision' : 'IOMC.EventVertexGenerators.VtxSmearedRealistic2024PbPbCollision_cfi',
     'Nominal2025OOCollision' : 'IOMC.EventVertexGenerators.VtxSmearedNominal2025OOCollision_cfi',
+    'Realistic2025pOCollision' : 'IOMC.EventVertexGenerators.VtxSmearedRealistic2025pOCollision_cfi',
 }
 VtxSmearedDefaultKey='DBrealistic'
diff --git a/IOMC/EventVertexGenerators/python/VtxSmearedParameters_cfi.py b/IOMC/EventVertexGenerators/python/VtxSmearedParameters_cfi.py
index 698e6e7e16048..83dfbe7974e2a 100644
--- a/IOMC/EventVertexGenerators/python/VtxSmearedParameters_cfi.py
+++ b/IOMC/EventVertexGenerators/python/VtxSmearedParameters_cfi.py
@@ -1110,6 +1110,19 @@
     Z0 = cms.double(0.3423956)
 )
 
+# From 2025 pO data runs 393975-394007)
+Realistic2025pOCollisionVtxSmearingParameters = cms.PSet(
+    Phi = cms.double(0.0),
+    BetaStar = cms.double(100),
+    Emittance = cms.double(3.835e-08),
+    Alpha = cms.double(0.0),
+    SigmaZ = cms.double(4.855060),
+    TimeOffset = cms.double(0.0),
+    X0 = cms.double(0.041049),
+    Y0 = cms.double(-0.008035),
+    Z0 = cms.double(0.569058)
+)
+
 # Parameters for HL-LHC operation at 13TeV
 HLLHCVtxSmearingParameters = cms.PSet(
     MeanXIncm = cms.double(0.),
diff --git a/IOMC/EventVertexGenerators/python/VtxSmearedRealistic2025pOCollision_cfi.py b/IOMC/EventVertexGenerators/python/VtxSmearedRealistic2025pOCollision_cfi.py
new file mode 100644
index 0000000000000..2cbb872a87a75
--- /dev/null
+++ b/IOMC/EventVertexGenerators/python/VtxSmearedRealistic2025pOCollision_cfi.py
@@ -0,0 +1,7 @@
+import FWCore.ParameterSet.Config as cms
+
+from IOMC.EventVertexGenerators.VtxSmearedParameters_cfi import Realistic2025pOCollisionVtxSmearingParameters,VtxSmearedCommon
+VtxSmeared = cms.EDProducer("BetafuncEvtVtxGenerator",
+    Realistic2025pOCollisionVtxSmearingParameters,
+    VtxSmearedCommon
+)
\ No newline at end of file