diff --git a/Configuration/StandardSequences/python/VtxSmeared.py b/Configuration/StandardSequences/python/VtxSmeared.py
index 088e1237404a4..e9305be3931a2 100644
--- a/Configuration/StandardSequences/python/VtxSmeared.py
+++ b/Configuration/StandardSequences/python/VtxSmeared.py
@@ -75,5 +75,6 @@
     'Realistic2023PbPbCollision' : 'IOMC.EventVertexGenerators.VtxSmearedRealistic2023PbPbCollision_cfi',
     'Realistic2024ppRefCollision' : 'IOMC.EventVertexGenerators.VtxSmearedRealistic2024ppRefCollision_cfi',
     'Realistic2024PbPbCollision' : 'IOMC.EventVertexGenerators.VtxSmearedRealistic2024PbPbCollision_cfi',
+    'Nominal2025OOCollision' : 'IOMC.EventVertexGenerators.VtxSmearedNominal2025OOCollision_cfi',
 }
 VtxSmearedDefaultKey='DBrealistic'
diff --git a/IOMC/EventVertexGenerators/python/VtxSmearedNominal2025OOCollision_cfi.py b/IOMC/EventVertexGenerators/python/VtxSmearedNominal2025OOCollision_cfi.py
new file mode 100644
index 0000000000000..fa9da284b515f
--- /dev/null
+++ b/IOMC/EventVertexGenerators/python/VtxSmearedNominal2025OOCollision_cfi.py
@@ -0,0 +1,7 @@
+import FWCore.ParameterSet.Config as cms
+
+from IOMC.EventVertexGenerators.VtxSmearedParameters_cfi import Nominal2025OOCollisionVtxSmearingParameters,VtxSmearedCommon
+VtxSmeared = cms.EDProducer("BetafuncEvtVtxGenerator",
+    Nominal2025OOCollisionVtxSmearingParameters,
+    VtxSmearedCommon
+)
diff --git a/IOMC/EventVertexGenerators/python/VtxSmearedParameters_cfi.py b/IOMC/EventVertexGenerators/python/VtxSmearedParameters_cfi.py
index 17ec6addd55a5..698e6e7e16048 100644
--- a/IOMC/EventVertexGenerators/python/VtxSmearedParameters_cfi.py
+++ b/IOMC/EventVertexGenerators/python/VtxSmearedParameters_cfi.py
@@ -1097,6 +1097,19 @@
     Z0 = cms.double(0.2290316)
 )
 
+# Estimate for the 2025 OO beam conditions, based on the 2024 PbPb beam width parameters from Realistic2024PbPbCollisionVtxSmearingParameters with the pp beam centroid from runs 392109 and 392112
+Nominal2025OOCollisionVtxSmearingParameters = cms.PSet(
+    Phi = cms.double(0.0),
+    BetaStar = cms.double(50),
+    Emittance = cms.double(6.684e-08),
+    Alpha = cms.double(0.0),
+    SigmaZ = cms.double(4.9068349),
+    TimeOffset = cms.double(0.0),
+    X0 = cms.double(0.0184194),
+    Y0 = cms.double(-0.0141852),
+    Z0 = cms.double(0.3423956)
+)
+
 # Parameters for HL-LHC operation at 13TeV
 HLLHCVtxSmearingParameters = cms.PSet(
     MeanXIncm = cms.double(0.),