diff --git a/build-with-pip.file b/build-with-pip.file
index b27a27cfa9e..7d5567874eb 100644
--- a/build-with-pip.file
+++ b/build-with-pip.file
@@ -8,6 +8,10 @@
 #Pip<Pre|Post><Section>: Extra macros to run extra commands for various sections e.g
 #PipPostBuild to relocate hardcoded pyton paths
 #define PipPostBuild perl -p -i -e "s|^#!.*python|#!/usr/bin/env python|" %{i}/bin/*
+#PipPackageNameCommand to get the exact package name
+#PipDepsMatch Command to find out pypi package dependencies
+#PipDepsCommand to get package dependencies
+#PipInstallCommand Command to install the package
 
 ## INITENV +PATH PYTHON3PATH %{i}/${PYTHON3_LIB_SITE_PACKAGES}
 
@@ -40,6 +44,18 @@
 %if "%{?PipDepsPost:set}" != "set"
 %define PipDepsPost %{nil}
 %endif
+%if "%{?PipPackageNameCommand:set}" != "set"
+%define PipPackageNameCommand pip3 show %{pip_name} --disable-pip-version-check | grep '^Name:' | sed 's|^Name: *||;s| ||g'
+%endif
+%if "%{?PipDepsMatch:set}" != "set"
+%define PipDepsMatch grep "^${PKG_NAME}  *%{realversion}  *requires " | sed 's|,.*||;s|.* |py3-|'
+%endif
+%if "%{?PipDepsCommand:set}" != "set"
+%define PipDepsCommand pip3 check --disable-pip-version-check | %{PipDepsMatch} %{PipDepsPost} | tr '\\n' ' '
+%endif
+%if "%{?PipInstallCommand:set}" != "set"
+%define PipInstallCommand pip3 install --no-clean --no-deps --no-index --no-build-isolation --no-cache-dir --disable-pip-version-check --user -v %{PipInstallOptions} %{PipBuildOptions} $PIPFILE
+%endif
 
 %define pip pip3&package_dependency=py3-pip
 Requires: python3 py3-pip py3-setuptools
@@ -101,16 +117,16 @@ if [ $(cat files.list | wc -l) -eq 1 ] ; then
    export PYTHONUSERBASE=%{i}
    pip3 list --disable-pip-version-check
    %{?PipPreBuildPy:%PipPreBuildPy}
-   pip3 install --no-clean --no-deps --no-index --no-build-isolation --no-cache-dir --disable-pip-version-check --user -v %{PipInstallOptions} %{PipBuildOptions} $PIPFILE
-   PKG_NAME=$(pip3 show %{pip_name} --disable-pip-version-check | grep '^Name:' | sed 's|^Name: *||;s| ||g')
+   %{PipInstallCommand}
+   PKG_NAME=$(%{PipPackageNameCommand})
    [ "${PKG_NAME}" = "" ] && exit 1
-   DEPS=$(pip3 check --disable-pip-version-check | grep "^${PKG_NAME}  *%{realversion}  *requires " | sed 's|,.*||;s|.* |py3-|' %{PipDepsPost} | tr '\n' ' ')
+   DEPS=$(%{PipDepsCommand})
    if [ "$DEPS" != "" ] ; then
-      echo "ERROR: Missing dependencies for %n (python3) found: $DEPS"
-      exit 1
-    fi
-    %{relocatePy3SitePackages}
-    %{?PipPostBuildPy:%PipPostBuildPy}
+     echo "ERROR: Missing dependencies for %n (python3) found: $DEPS"
+     exit 1
+   fi
+   %{relocatePy3SitePackages}
+   %{?PipPostBuildPy:%PipPostBuildPy}
 else
    echo "Sorry I don't know how to handle no/multiple install files yet"
    cat %{_builddir}/files.list
diff --git a/curl.spec b/curl.spec
index 9ca2b26ab3b..6e25d50973b 100644
--- a/curl.spec
+++ b/curl.spec
@@ -1,4 +1,4 @@
-### RPM external curl 7.70.0
+### RPM external curl 7.79.0
 Source: http://curl.haxx.se/download/%{n}-%{realversion}.tar.gz
 Requires: zlib
 
@@ -20,7 +20,8 @@ esac
   --with-zlib=${ZLIB_ROOT} \
   --without-nss \
   --without-libssh2 \
-  --with-gssapi=${KERBEROS_ROOT}
+  --with-gssapi=${KERBEROS_ROOT} \
+  --with-openssl
 
 make %{makeprocesses}
 
diff --git a/pcre2.spec b/pcre2.spec
index 016180f3132..28a2861ddf4 100644
--- a/pcre2.spec
+++ b/pcre2.spec
@@ -1,4 +1,4 @@
-### RPM external pcre2 10.33
+### RPM external pcre2 10.36
 Source0: http://downloads.sourceforge.net/pcre/%{n}-%{realversion}.tar.bz2
 
 Requires: bz2lib zlib
diff --git a/pip/numexpr.file b/pip/numexpr.file
index a8ba8bf59d7..617f73a68a0 100644
--- a/pip/numexpr.file
+++ b/pip/numexpr.file
@@ -1 +1 @@
-Requires: py3-numpy
+Requires: py3-numpy py3-packaging
diff --git a/pip/requirements.txt b/pip/requirements.txt
index 463d66e9651..5fb4a8df1e9 100644
--- a/pip/requirements.txt
+++ b/pip/requirements.txt
@@ -105,8 +105,6 @@ histbook==1.2.5
 histoprint==2.2.0
 histogrammar==1.0.25
 html5lib==1.1
-hyperas==0.4.1
-hyperopt==0.2.5
 idna==3.2
 immutables==0.16
 importlib-metadata==4.8.1
@@ -170,12 +168,10 @@ nbformat==5.1.3
 nest-asyncio==1.5.1
 networkx==2.6.2
 neurolab==0.3.5
-nose-parameterized==0.6.0
-nose==1.3.7
 node-semver==0.8.0
 notebook==6.4.3
 numba==0.54.0
-numexpr==2.7.3
+numexpr==2.8.1
 numpy==1.21.2
 onnx==1.10.1
 onnxmltools==1.9.1
diff --git a/py3-pip.spec b/py3-pip.spec
index 25e3e388582..9babceb7c75 100644
--- a/py3-pip.spec
+++ b/py3-pip.spec
@@ -1,4 +1,4 @@
-### RPM external py3-pip 20.3.3
+### RPM external py3-pip 22.0.4
 ## INITENV +PATH PATH %{i}/bin
 ## INITENV +PATH LD_LIBRARY_PATH %{i}/lib
 ## INITENV +PATH PYTHON3PATH %{i}/${PYTHON3_LIB_SITE_PACKAGES}
diff --git a/py3-setuptools.spec b/py3-setuptools.spec
index a8ed2e42db3..7c399c9919b 100644
--- a/py3-setuptools.spec
+++ b/py3-setuptools.spec
@@ -1,4 +1,4 @@
-### RPM external py3-setuptools 51.3.3
+### RPM external py3-setuptools 60.9.3
 ## INITENV +PATH PYTHON3PATH %{i}/${PYTHON3_LIB_SITE_PACKAGES}
 
 Source: https://github.com/pypa/setuptools/archive/v%{realversion}.tar.gz
@@ -9,14 +9,12 @@ Requires: python3
 %setup -n setuptools-%{realversion}
 
 %build
-python3 bootstrap.py
 python3 setup.py build
+python3 setup.py egg_info
 
 %install
 python3 setup.py install --single-version-externally-managed --record=/dev/null --skip-build --prefix=%{i}
 sed -i 's|#!.*python.*|#!/usr/bin/env python3|' \
- %{i}/bin/* \
  %{i}/${PYTHON3_LIB_SITE_PACKAGES}/setuptools/command/easy_install.py \
  %{i}/${PYTHON3_LIB_SITE_PACKAGES}/pkg_resources/_vendor/appdirs.py
-mv %{i}/bin/easy_install %{i}/bin/easy_install3