From 90d000f300861456efced025fb1d0dc44df26ae9 Mon Sep 17 00:00:00 2001
From: ch-kr <kchao@broadinstitute.org>
Date: Thu, 23 Oct 2025 09:58:25 -0400
Subject: [PATCH 1/3] add v5 to DOWNSAMPLINGS constant

---
 gnomad/resources/grch38/gnomad.py | 8 ++++++++
 1 file changed, 8 insertions(+)

diff --git a/gnomad/resources/grch38/gnomad.py b/gnomad/resources/grch38/gnomad.py
index 8bbd2a98c..23ed85e48 100644
--- a/gnomad/resources/grch38/gnomad.py
+++ b/gnomad/resources/grch38/gnomad.py
@@ -308,6 +308,14 @@
         200000,
         500000,
     ],
+    # Need to update these with final counts.
+    "v5": [
+        10000,
+        62145,
+        67336,
+        100000,
+        199794,
+    ],
 }
 """
 List of the downsampling numbers to use for frequency calculations by version.

From 954892f181a5eb3c565553dd411bae7f5947818b Mon Sep 17 00:00:00 2001
From: ch-kr <kchao@broadinstitute.org>
Date: Fri, 7 Nov 2025 10:16:28 -0500
Subject: [PATCH 2/3] update v5 downsamplings with current meta counts

---
 gnomad/resources/grch38/gnomad.py | 6 +++---
 1 file changed, 3 insertions(+), 3 deletions(-)

diff --git a/gnomad/resources/grch38/gnomad.py b/gnomad/resources/grch38/gnomad.py
index 23ed85e48..a074bf0f8 100644
--- a/gnomad/resources/grch38/gnomad.py
+++ b/gnomad/resources/grch38/gnomad.py
@@ -311,10 +311,10 @@
     # Need to update these with final counts.
     "v5": [
         10000,
-        62145,
-        67336,
+        51698,
+        68269,
         100000,
-        199794,
+        189824,
     ],
 }
 """

From 2f2f6fbcfb2441ef9dbec2a00d7c88f87de6df0d Mon Sep 17 00:00:00 2001
From: ch-kr <kchao@broadinstitute.org>
Date: Mon, 8 Dec 2025 16:30:18 -0500
Subject: [PATCH 3/3] update v5 downsampling numbers

---
 gnomad/resources/grch38/gnomad.py | 7 +++----
 1 file changed, 3 insertions(+), 4 deletions(-)

diff --git a/gnomad/resources/grch38/gnomad.py b/gnomad/resources/grch38/gnomad.py
index a074bf0f8..bfa3e1c99 100644
--- a/gnomad/resources/grch38/gnomad.py
+++ b/gnomad/resources/grch38/gnomad.py
@@ -308,13 +308,12 @@
         200000,
         500000,
     ],
-    # Need to update these with final counts.
     "v5": [
         10000,
-        51698,
-        68269,
+        59355,
+        89074,
         100000,
-        189824,
+        223733,
     ],
 }
 """