NOTICE

VFDistiller — Variant Fusion Distiller
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Copyright (C) 2026 Lukas Geiger (c/o Um:bruch Think Tank)
Licensed under the GNU Affero General Public License v3.0 or later
(AGPL-3.0-or-later). See LICENSE for the full text.

This NOTICE file is provided for informational purposes alongside the
license and must be preserved in redistributions of the source code
and in substantial portions of the software.

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1. Research Use Only / Not for Clinical Use
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VFDistiller is a bioinformatics research and teaching tool for the
processing, conversion and annotation of genetic variant files (VCF,
gVCF, 23andMe raw format, FASTA). It is explicitly:

  * NOT a CE-marked in-vitro diagnostic medical device (IVD) within
    the meaning of Regulation (EU) 2017/746 (IVDR).
  * NOT certified by BfArM, a notified body or any other regulator.
  * NOT intended for clinical diagnosis, prognosis, therapeutic
    decision-making, or the interpretation of clinical test results
    (including in the consumer-genomics context).
  * NOT a medical opinion, diagnosis or recommendation.

The ClinSig values (from ClinVar), variant-impact predictions (from
Ensembl VEP, AlphaGenome) and allele-frequency annotations (from
gnomAD, ALFA, TOPMed) that VFDistiller displays are database
annotations reproduced from third-party research sources. They are
for scientific orientation only and must not be used as a basis for
clinical decisions.

Any person using VFDistiller to interpret real human genetic data must
consult qualified human-genetics professionals.

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2. No Medical Device / Kein Medizinprodukt
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Zweckbestimmung (German, binding for the European market):

  VFDistiller ist ein bioinformatisches Desktop-Tool zur technischen
  Verarbeitung, Format-Konvertierung und Annotation genetischer
  Variantendaten. Die Software ist ausschließlich für Forschung,
  Lehre und Software-Entwicklung bestimmt. Sie ist KEIN
  In-vitro-Diagnostikum, KEIN Medizinprodukt und darf weder für die
  klinische Diagnose noch für therapeutische Entscheidungen
  verwendet werden.

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3. Liability / Haftung (Schenkungshaftung)
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VFDistiller is distributed free of charge as an unentgeltliche
Open-Source-Schenkung (§§ 516 ff. BGB). Liability is limited to
intent and gross negligence in accordance with § 521 BGB and
§§ 15–17 AGPL-3.0. Liability for damage to life, body and health
remains unaffected under German mandatory law.

The Product Liability Directive (EU) 2024/2853 contains an
open-source exception (Art. 4 (3)); its applicability to software
distributed via commercial app stores is legally disputed and not
guaranteed here.

USE AT YOUR OWN RISK.

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4. Third-Party Components
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VFDistiller bundles or depends on third-party libraries licensed
under MIT, BSD, Apache-2.0, PIL License, Biopython License and
compatible permissive licenses. See README/licenses/THIRD_PARTY_LICENSES.txt
for the full list and license texts.

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5. Contact
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Source repository: https://github.com/biotec-line/VFDistiller
Author / Maintainer: Lukas Geiger, c/o Um:bruch Think Tank
ORCID: https://orcid.org/0009-0005-7296-1534