diff --git a/.mypy.ini b/.mypy.ini
index 4a1333c4704..12aac2be56c 100644
--- a/.mypy.ini
+++ b/.mypy.ini
@@ -34,3 +34,6 @@ ignore_missing_imports = True
 
 [mypy-gunicorn.*]
 ignore_missing_imports = True
+
+[mypy-hyperscan]
+ignore_missing_imports = True
diff --git a/aiohttp/web_urldispatcher.py b/aiohttp/web_urldispatcher.py
index e16f973984c..5e59ad05664 100644
--- a/aiohttp/web_urldispatcher.py
+++ b/aiohttp/web_urldispatcher.py
@@ -41,6 +41,7 @@
 from .abc import AbstractMatchInfo, AbstractRouter, AbstractView
 from .helpers import DEBUG
 from .http import HttpVersion11
+from .log import web_logger
 from .typedefs import Handler, PathLike
 from .web_exceptions import (
     HTTPException,
@@ -68,6 +69,14 @@
 )
 
 
+try:
+    import hyperscan
+
+    HAS_HYPERSCAN = True
+except ImportError:
+    HAS_HYPERSCAN = False
+
+
 if TYPE_CHECKING:
     from .web_app import Application
 
@@ -735,6 +744,7 @@ def __init__(self, prefix: str, app: "Application") -> None:
     def add_prefix(self, prefix: str) -> None:
         super().add_prefix(prefix)
         self._add_prefix_to_resources(prefix)
+        self._app.router._rebuild()
 
     def _add_prefix_to_resources(self, prefix: str) -> None:
         router = self._app.router
@@ -998,28 +1008,98 @@ def __init__(self) -> None:
         self._named_resources: Dict[str, AbstractResource] = {}
         self._resource_index: dict[str, list[AbstractResource]] = {}
         self._matched_sub_app_resources: List[MatchedSubAppResource] = []
+        self._hyperdb: Optional[hyperscan.Database] = None  # type: ignore[no-any-unimported]
+        self._plain_resources: dict[str, PlainResource] = {}
+        self._prefix_resources: dict[tuple[str, ...], list[PrefixResource]] = {}
+        self._max_prefix_cardinality = 0
+        self._has_variable_resources = True
+
+    def _on_match(
+        self, id_: int, from_: int, to: int, flags: int, found: list[int]
+    ) -> Optional[bool]:
+        found.append(id_)
+        return None
 
     async def resolve(self, request: Request) -> UrlMappingMatchInfo:
-        resource_index = self._resource_index
-        allowed_methods: Set[str] = set()
+        allowed_methods: set[str] = set()
+        path = request.rel_url.path_safe
+
+        # plain resource lookup
+        if (plain_resource := self._plain_resources.get(path)) is not None:
+            match_dict, allowed = await plain_resource.resolve(request)
+            if match_dict is not None:
+                return match_dict
+            else:
+                allowed_methods |= allowed
 
+        # prefix resource lookup
+        parts = tuple(
+            path[1:].split("/", self._max_prefix_cardinality)[
+                : self._max_prefix_cardinality
+            ]
+        )
+        prefix_resources = self._prefix_resources
         # Walk the url parts looking for candidates. We walk the url backwards
         # to ensure the most explicit match is found first. If there are multiple
         # candidates for a given url part because there are multiple resources
         # registered for the same canonical path, we resolve them in a linear
         # fashion to ensure registration order is respected.
-        url_part = request.rel_url.path_safe
-        while url_part:
-            for candidate in resource_index.get(url_part, ()):
-                match_dict, allowed = await candidate.resolve(request)
+        while True:
+            for prefix_resource in prefix_resources.get(parts, ()):
+                match_dict, allowed = await prefix_resource.resolve(request)
                 if match_dict is not None:
                     return match_dict
                 else:
                     allowed_methods |= allowed
-            if url_part == "/":
+            if len(parts) <= 1:
                 break
-            url_part = url_part.rpartition("/")[0] or "/"
-
+            parts = parts[:-1]
+
+        # variable resource lookup
+        if self._has_variable_resources:
+            if self._hyperdb is not None:
+                found: list[int] = []
+                resources = self._resources
+
+                self._hyperdb.scan(
+                    path.encode("utf8"),
+                    match_event_handler=self._on_match,
+                    context=found,
+                )
+                if len(found) > 1:
+                    # Multiple matches are found,
+                    # use the FIRST match.
+                    # Match ids are basically indexes in self._resources.
+                    found.sort()
+
+                for idx in found:
+                    resource = resources[idx]
+                    match_dict, allowed = await resource.resolve(request)
+                    if match_dict is not None:
+                        return match_dict
+                    else:
+                        allowed_methods |= allowed
+            else:
+                url_part = path
+                resource_index = self._resource_index
+
+                # Walk the url parts looking for candidates. We walk the url backwards
+                # to ensure the most explicit match is found first. If there are multiple
+                # candidates for a given url part because there are multiple resources
+                # registered for the same canonical path, we resolve them in a linear
+                # fashion to ensure registration order is respected.
+                while url_part:
+                    for candidate in resource_index.get(url_part, ()):
+                        match_dict, allowed = await candidate.resolve(request)
+                        if match_dict is not None:
+                            return match_dict
+                        else:
+                            allowed_methods |= allowed
+                    if url_part == "/":
+                        break
+                    url_part = url_part.rpartition("/")[0] or "/"
+
+        # domain resource lookup
         #
         # We didn't find any candidates, so we'll try the matched sub-app
         # resources which we have to walk in a linear fashion because they
@@ -1239,6 +1319,62 @@ def freeze(self) -> None:
         super().freeze()
         for resource in self._resources:
             resource.freeze()
+        self._rebuild()
+
+    def _rebuild(self) -> None:
+        self._hyperdb = None
+        self._plain_resources.clear()
+        self._prefix_resources.clear()
+        self._max_prefix_cardinality = 0
+        patterns: list[bytes] = []
+        ids: list[int] = []
+        for id_, resource in enumerate(self._resources):
+            if isinstance(resource, PlainResource):
+                self._plain_resources[resource.get_info()["path"]] = resource
+            elif isinstance(resource, DynamicResource):
+                pattern = resource.get_info()["pattern"].pattern
+                patterns.append(f"^{pattern}$".encode())
+                ids.append(id_)
+            elif isinstance(resource, PrefixResource):
+                if isinstance(resource, MatchedSubAppResource):
+                    # wildcard resources doesn't fit hyperscan table
+                    continue
+                prefix = resource.get_info()["prefix"]
+                # There may be multiple resources for a prefix
+                # so we keep them in a list to ensure that registration
+                # order is respected.
+                parts = tuple(prefix.split("/")[1:])
+                self._prefix_resources.setdefault(parts, []).append(resource)
+                self._max_prefix_cardinality = max(
+                    self._max_prefix_cardinality, len(parts)
+                )
+                # breakpoint()
+            else:
+                raise RuntimeError(f"Unsupported resource type {type(resource)}")
+
+        count = len(patterns)
+        self._has_variable_resources = count > 0
+        if self._has_variable_resources:
+            if HAS_HYPERSCAN:
+                self._hyperdb = hyperscan.Database()
+                try:
+                    self._hyperdb.compile(
+                        expressions=patterns,
+                        ids=ids,
+                        elements=count,
+                        flags=[
+                            hyperscan.HS_FLAG_UTF8
+                            | hyperscan.HS_FLAG_UCP
+                            | hyperscan.HS_FLAG_SINGLEMATCH
+                        ]
+                        * count,
+                    )
+                except hyperscan.error as exc:
+                    web_logger.warning(
+                        "Cannot compile hyperscan database: %s, switching to fallback url resolver",
+                        repr(exc),
+                    )
+                    self._hyperdb = None
 
     def add_routes(self, routes: Iterable[AbstractRouteDef]) -> List[AbstractRoute]:
         """Append routes to route table.
diff --git a/requirements/runtime-deps.in b/requirements/runtime-deps.in
index 48ee7016d13..be075fe615a 100644
--- a/requirements/runtime-deps.in
+++ b/requirements/runtime-deps.in
@@ -7,6 +7,7 @@ async-timeout >= 4.0, < 6.0 ; python_version < "3.11"
 Brotli; platform_python_implementation == 'CPython'
 brotlicffi; platform_python_implementation != 'CPython'
 frozenlist >= 1.1.1
+hyperscan >= 0.7.8; platform_python_implementation == 'CPython' and (sys_platform=="linux" or sys_platform=="darwin")
 multidict >=4.5, < 7.0
 propcache >= 0.2.0
 yarl >= 1.17.0, < 2.0
diff --git a/requirements/runtime-deps.txt b/requirements/runtime-deps.txt
index 6ef30951c89..2c5450dd964 100644
--- a/requirements/runtime-deps.txt
+++ b/requirements/runtime-deps.txt
@@ -20,6 +20,8 @@ frozenlist==1.5.0
     # via
     #   -r requirements/runtime-deps.in
     #   aiosignal
+hyperscan == 0.7.8 ; platform_python_implementation == "CPython" and (sys_platform=="linux" or sys_platform=="darwin")
+    # via -r requirements/runtime-deps.in
 idna==3.6
     # via yarl
 multidict==6.1.0
diff --git a/setup.cfg b/setup.cfg
index 66b779b8db9..e9dd87ce2df 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -70,6 +70,7 @@ speedups =
   aiodns >= 3.2.0; sys_platform=="linux" or sys_platform=="darwin"
   Brotli; platform_python_implementation == 'CPython'
   brotlicffi; platform_python_implementation != 'CPython'
+  hyperscan >= 0.7.8; platform_python_implementation == 'CPython' and (sys_platform=="linux" or sys_platform=="darwin")
 
 [options.packages.find]
 exclude =