diff --git a/Dockerfile.macos b/Dockerfile.macos
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+FROM python:3.10.6-slim-bullseye AS compile-image
+
+ENV DEBIAN_FRONTEND=noninteractive
+
+# Install git to be able to set the pySCENIC version.
+RUN apt-get update && \
+    apt-get -y --no-install-recommends install git gcc python3-dev
+
+# Create virtual environment.
+RUN python -m venv /opt/venv
+
+# Make sure we use the virtual environment.
+ENV PATH="/opt/venv/bin:$PATH"
+
+# Install pySCENIC dependencies with pip.
+COPY requirements.txt /tmp/
+RUN pip install --no-cache-dir -r /tmp/requirements.txt
+
+# Install scanpy, MulticoreTSNE and ipykernel.
+#COPY requirements_docker_with_scanpy.txt /tmp/
+#RUN pip install --no-cache-dir -r /tmp/requirements_docker_with_scanpy.txt
+
+# Install pySCENIC from local copy:
+COPY . /tmp/pySCENIC
+RUN  cd /tmp/pySCENIC && \
+     pip install . && \
+     cd .. && rm -rf pySCENIC
+
+FROM python:3.10.6-slim-bullseye AS build-image
+
+RUN apt-get -y update && \
+    apt-get -y upgrade && \
+    apt-get -y --no-install-recommends install \
+        # Need to run ps
+        procps \
+        libxml2 \
+        less && \
+    rm -rf /var/cache/apt/* && \
+    rm -rf /var/lib/apt/lists/*
+
+COPY --from=compile-image /opt/venv /opt/venv
+
+# Make sure we use the virtualenv:
+ENV PATH="/opt/venv/bin:$PATH"
+
+EXPOSE 8787
+