diff --git a/spack_repo/nwchemex/common/mixins/__init__.py b/spack_repo/nwchemex/common/mixins/__init__.py
index 63c84d2..5d82e1a 100644
--- a/spack_repo/nwchemex/common/mixins/__init__.py
+++ b/spack_repo/nwchemex/common/mixins/__init__.py
@@ -1,4 +1,13 @@
 from .cmaize import CMaizePackage
-from .nwchemex import NWChemExBaseCXX, NWChemExBasePybindings
+from .nwchemex import (
+    NWChemExBaseCXX,
+    NWChemExBasePybindings,
+    NWChemExBasePython,
+)
 
-__all__ = ["CMaizePackage", "NWChemExBaseCXX", "NWChemExBasePybindings"]
+__all__ = [
+    "CMaizePackage",
+    "NWChemExBaseCXX",
+    "NWChemExBasePybindings",
+    "NWChemExBasePython",
+]
diff --git a/spack_repo/nwchemex/common/mixins/nwchemex.py b/spack_repo/nwchemex/common/mixins/nwchemex.py
index f9f41ea..a2fa8a1 100644
--- a/spack_repo/nwchemex/common/mixins/nwchemex.py
+++ b/spack_repo/nwchemex/common/mixins/nwchemex.py
@@ -2,6 +2,7 @@
 
 from spack import package as pkg
 from spack.package_base import PackageBase
+from spack_repo.builtin.build_systems.python import PythonPackage
 
 from .cmaize import CMaizePackage
 
@@ -29,17 +30,6 @@ class NWChemExBaseCXX(NWChemExBaseGit, CMaizePackage):
         sticky=True,
     )
 
-    pkg.variant(
-        "cxxstd",
-        default="17",
-        # NOTE: Comma after "17" is necessary so Spack doesn't split it into
-        #       individual characters
-        values=("17",),
-        multi=False,
-        description="Use the specified C++ standard when building",
-        sticky=True,
-    )
-
     pkg.depends_on("cxx", type="build")
 
     # Test dependencies
@@ -55,7 +45,6 @@ def cmake_args(self):
                 ),
                 self.define_from_variant("BUILD_SHARED_LIBS", "shared"),
                 self.define_from_variant("BUILD_DOCS", "docs"),
-                self.define_from_variant("CMAKE_CXX_STANDARD", "cxxstd"),
                 self.define("BUILD_TESTING", self.run_tests),
             ]
         )
@@ -87,13 +76,24 @@ def cmake_args(self):
 class NWChemExBasePybindings(NWChemExBaseCXX):
 
     pkg.variant(
-        "pybindings",
-        default=False,
-        description="Build the Python bindings with Pybind11",
-        sticky=True,
+        "python",
+        default=True,
+        description="Build the Python bindings",
+        # sticky=True,
     )
 
-    pkg.depends_on("py-pybind11", when="+pybindings")
+    # https://spack.readthedocs.io/en/latest/build_systems/pythonpackage.html#extends-vs-depends-on
+    pkg.extends("python", when="+python")
+    pkg.depends_on(
+        "py-pybind11@3:",
+        type=("build", "link", "run", "test"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "python@3:",
+        type=("build", "link", "run", "test"),
+        when="+python",
+    )
 
     def cmake_args(self):
         args = super().cmake_args()
@@ -101,25 +101,25 @@ def cmake_args(self):
         args.extend(
             [
                 self.define_from_variant(
-                    "BUILD_PYBIND11_PYBINDINGS", "pybindings"
+                    "BUILD_PYBIND11_PYBINDINGS", "python"
                 ),
-                self.define_from_variant("PYBIND11_FINDPYTHON", "pybindings"),
+                self.define_from_variant("PYBIND11_FINDPYTHON", "python"),
             ]
         )
 
-        if self.spec.satisfies("+pybindings"):
-            if "NWX_MODULE_DIRECTORY" in os.environ:
-                args.append(
-                    self.define(
-                        "NWX_MODULE_DIRECTORY",
-                        os.environ["NWX_MODULE_DIRECTORY"],
-                    )
+        if self.spec.satisfies("+python"):
+            args.append(
+                self.define(
+                    "NWX_MODULE_DIRECTORY",
+                    # lib64 is used for platlib from Python package
+                    self.prefix.lib.join(
+                        "python{}".format(self.spec["python"].version[:-1])
+                    ).join("site-packages"),
                 )
-            # TODO: Allow the user to configure this?
-            # args.append(
-            #     "-DNWX_MODULE_DIRECTORY={}".format(
-            #         self.prefix.lib.join(self.project.lower()).join("python")
-            #     )
-            # )
+            )
 
         return args
+
+
+class NWChemExBasePython(NWChemExBaseGit, PythonPackage):
+    pass
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_chemcache/package.py b/spack_repo/nwchemex/core/packages/nwchemex_chemcache/package.py
index c366f5c..bb28e16 100644
--- a/spack_repo/nwchemex/core/packages/nwchemex_chemcache/package.py
+++ b/spack_repo/nwchemex/core/packages/nwchemex_chemcache/package.py
@@ -48,7 +48,7 @@ class NwchemexChemcache(NWChemExBasePybindings):
     pkg.maintainers("ryanmrichard", "jwaldrop107", "zachcran")
     pkg.license("Apache-2.0", checked_by="zachcran")
 
-    pkg.version("generated_data", branch="generated_data")
+    pkg.version("generated_data", branch="generated_data", preferred=True)
 
     # Versions from git tags
     pkg.version(
@@ -56,24 +56,19 @@ class NwchemexChemcache(NWChemExBasePybindings):
         sha256="5efb2a60d75aaa57e08e8b2a0b84a24e502083fa5bacae416406ec59bd2839b8",
     )
 
-    # TODO: Are we sure this shouldn't be here to propagate down to SimDE?
-    # pkg.variant(
-    #     "sigma",
-    #     default=False,
-    #     description="Enable Sigma for uncertainty tracking",
-    #     sticky=True,
-    # )
-    pkg.variant(
-        "experimental",
-        default=False,
-        description="Enable experimental features",
-        sticky=False,
-    )
-
-    # Runtime dependencies
+    pkg.depends_on("py-requests@2.16:")
 
     # First-party
-    pkg.depends_on("nwchemex-simde")
+    pkg.depends_on(
+        "nwchemex-simde+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-simde~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
 
     # Start with CMaize sanity check locations
     sanity_check_is_dir = NWChemExBasePybindings.cmaize_sanity_check_dirs(
@@ -83,16 +78,3 @@ class NwchemexChemcache(NWChemExBasePybindings):
         project.lower()
     )
     # Append more sanity checks as needed
-
-    def cmake_args(self):
-        args = super().cmake_args()
-
-        args.extend(
-            [
-                self.define_from_variant(
-                    "ENABLE_EXPERIMENTAL_FEATURES", "experimental"
-                ),
-            ]
-        )
-
-        return args
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_chemist/package.py b/spack_repo/nwchemex/core/packages/nwchemex_chemist/package.py
index e6e3bb5..b075f91 100644
--- a/spack_repo/nwchemex/core/packages/nwchemex_chemist/package.py
+++ b/spack_repo/nwchemex/core/packages/nwchemex_chemist/package.py
@@ -63,8 +63,27 @@ class NwchemexChemist(NWChemExBasePybindings):
 
     # First-party
     pkg.depends_on("nwchemex-utilities")
-    pkg.depends_on("nwchemex-parallelzone")
-    pkg.depends_on("nwchemex-tensorwrapper")
+    pkg.depends_on(
+        "nwchemex-parallelzone+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-parallelzone~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
+
+    pkg.depends_on(
+        "nwchemex-tensorwrapper+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-tensorwrapper~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
 
     # Although we have a variant, technically it is not a direct dependency
     # of this package
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_friendzone/_package.py b/spack_repo/nwchemex/core/packages/nwchemex_friendzone/_package.py
new file mode 100644
index 0000000..1f1774e
--- /dev/null
+++ b/spack_repo/nwchemex/core/packages/nwchemex_friendzone/_package.py
@@ -0,0 +1,109 @@
+# Copyright 2013-2024 Lawrence Livermore National Security, LLC and other
+# Spack Project Developers. See the top-level COPYRIGHT file for details.
+#
+# SPDX-License-Identifier: (Apache-2.0 OR MIT)
+
+# ----------------------------------------------------------------------------
+# If you submit this package back to Spack as a pull request,
+# please first remove this boilerplate and all FIXME comments.
+#
+# This is a template package file for Spack.  We've put "FIXME"
+# next to all the things you'll want to change. Once you've handled
+# them, you can save this file and test your package like this:
+#
+#     spack install nwchemex-simde
+#
+# You can edit this file again by typing:
+#
+#     spack edit nwchemex-simde
+#
+# See the Spack documentation for more information on packaging.
+# ----------------------------------------------------------------------------
+
+from spack import package as pkg
+
+from spack_repo.nwchemex.common.mixins import NWChemExBasePybindings
+
+
+class NwchemexFriendzone(NWChemExBasePybindings):
+    """Generic, helpful C++ classes used by the NWChemEx project."""
+
+    project = "FriendZone"
+
+    homepage = f"https://github.com/NWChemEx/{project}"
+    url = f"https://github.com/NWChemEx/{project}/archive/refs/tags/v1.0.9.tar.gz"
+    git = f"https://github.com/NWChemEx/{project}.git"  # For the latest commit
+
+    # Versions are hosted under GitHub tags right now
+    list_url = f"https://github.com/NWChemEx/{project}/tags"
+    # To get older versions, uncomment 'list_depth' below and set it to a
+    # value >0 to get list_depth + 1 pages of versions.
+    # WARNING: This increases the number of links that the search spider will
+    # follow, meaning even 'list_depth = 1' may increase the search time
+    # significantly!
+    # list_depth = 1
+
+    pkg.maintainers("ryanmrichard", "jwaldrop107", "zachcran")
+    pkg.license("Apache-2.0", checked_by="zachcran")
+
+    # Versions from git tags
+    pkg.version(
+        "1.0.9",
+        sha256="fbf3b4a8f392e88e675696976d4d4927af1f158a2602f761796d415c1fbaeab1",
+    )
+
+    # TODO: Should this still be here for SimDE propagation?
+    # pkg.variant(
+    #     "sigma",
+    #     default=False,
+    #     description="Enable Sigma for uncertainty tracking",
+    #     sticky=True,
+    # )
+
+    pkg.depends_on("py-pip", when="+python", type=("build", "link"))
+    pkg.depends_on(
+        "py-pydantic", when="+python", type=("build", "link", "run")
+    )
+    pkg.depends_on(
+        "py-networkx~default", when="+python", type=("build", "link", "run")
+    )
+    pkg.depends_on(
+        "py-qcelemental", when="+python", type=("build", "link", "run")
+    )
+    pkg.depends_on(
+        "py-qcengine", when="+python", type=("build", "link", "run")
+    )
+    # pkg.depends_on("py-ase", when="+python", type=("build", "link", "run"))
+    pkg.depends_on("nwchem", when="+python", type=("build", "link", "run"))
+
+    # First-party
+    pkg.depends_on(
+        "nwchemex-simde+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-simde~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
+
+    # Start with CMaize sanity check locations
+    # sanity_check_is_dir = NWChemExBasePybindings.cmaize_sanity_check_dirs(
+    #     project.lower()
+    # )
+    # sanity_check_is_file = NWChemExBasePybindings.cmaize_sanity_check_files(
+    #     project.lower()
+    # )
+    # Append more sanity checks as needed
+
+    def cmake_args(self):
+        args = super().cmake_args()
+
+        args.extend(
+            [
+                self.define("ENABLE_ASE", "OFF"),
+            ]
+        )
+
+        return args
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_friendzone/package.py b/spack_repo/nwchemex/core/packages/nwchemex_friendzone/package.py
index 1203f76..03b9113 100644
--- a/spack_repo/nwchemex/core/packages/nwchemex_friendzone/package.py
+++ b/spack_repo/nwchemex/core/packages/nwchemex_friendzone/package.py
@@ -11,22 +11,22 @@
 # next to all the things you'll want to change. Once you've handled
 # them, you can save this file and test your package like this:
 #
-#     spack install nwchemex-simde
+#     spack install nwchemex-friendzone
 #
 # You can edit this file again by typing:
 #
-#     spack edit nwchemex-simde
+#     spack edit nwchemex-friendzone
 #
 # See the Spack documentation for more information on packaging.
 # ----------------------------------------------------------------------------
 
 from spack import package as pkg
 
-from spack_repo.nwchemex.common.mixins import NWChemExBasePybindings
+from spack_repo.nwchemex.common.mixins import NWChemExBasePython
 
 
-class NwchemexFriendzone(NWChemExBasePybindings):
-    """Generic, helpful C++ classes used by the NWChemEx project."""
+class NwchemexFriendzone(NWChemExBasePython):
+    """Provides SimDE-compatible APIs so that NWChemEx can play nicely with its friends."""
 
     project = "FriendZone"
 
@@ -48,46 +48,51 @@ class NwchemexFriendzone(NWChemExBasePybindings):
 
     # Versions from git tags
     pkg.version(
-        "1.0.9",
-        sha256="fbf3b4a8f392e88e675696976d4d4927af1f158a2602f761796d415c1fbaeab1",
+        "1.0.14",
+        sha256="b504cb1f20ed5839a1fc926650b2f4114b8ff985f2295f81980e05281c74d652",
     )
 
-    # TODO: Should this still be here for SimDE propagation?
-    # pkg.variant(
-    #     "sigma",
-    #     default=False,
-    #     description="Enable Sigma for uncertainty tracking",
-    #     sticky=True,
-    # )
     pkg.variant(
-        "experimental",
-        default=False,
-        description="Enable experimental features",
-        sticky=False,
+        "friends",
+        values=pkg.any_combination_of("molssi", "ase", "nwchem"),
+        # pkg.any_combination_of() automatically adds a "none" option and sets
+        # the following two options
+        # default="none",
+        # multi=True,
+        description=(
+            "Which friends to include. For multiple friends, use a "
+            "comma-separated list "
+            "(e.g. `spack install friendzone friends=molssi,ase`)"
+        ),
     )
 
-    pkg.depends_on("py-ase")
-    pkg.depends_on("nwchem")
+    # TODO: Many of these may be able to be switched to ("build", "run")
+    # instead of ("build", "link", "run")
+    pkg.depends_on("python@3.10:", type=("build", "run"))
+    pkg.depends_on("py-pip", type=("build", "link"))
+    pkg.depends_on("py-setuptools", type="build")
+    pkg.depends_on("py-pydantic", type=("build", "link", "run"))
+    with pkg.when("friends=molssi"):
+        pkg.depends_on("py-networkx~default", type=("build", "link", "run"))
+        pkg.depends_on("py-qcelemental", type=("build", "link", "run"))
+        pkg.depends_on("py-qcengine", type=("build", "link", "run"))
+    with pkg.when("friends=nwchem"):
+        pkg.depends_on("nwchem", type=("build", "link", "run"))
+    with pkg.when("friends=ase"):
+        pkg.depends_on("py-ase", type=("build", "link", "run"))
 
     # First-party
-    pkg.depends_on("nwchemex-simde")
+    pkg.depends_on(
+        "nwchemex-simde+python",
+        type=("build", "link", "run"),
+    )
 
+    # TODO: Add sanity checks
     # Start with CMaize sanity check locations
-    sanity_check_is_dir = NWChemExBasePybindings.cmaize_sanity_check_dirs(
-        project.lower()
-    )
-    sanity_check_is_file = NWChemExBasePybindings.cmaize_sanity_check_files(
-        project.lower()
-    )
+    # sanity_check_is_dir = NWChemExBasePybindings.cmaize_sanity_check_dirs(
+    #     project.lower()
+    # )
+    # sanity_check_is_file = NWChemExBasePybindings.cmaize_sanity_check_files(
+    #     project.lower()
+    # )
     # Append more sanity checks as needed
-
-    def cmake_args(self):
-        args = super().cmake_args()
-
-        args.extend(
-            self.define_from_variant(
-                "ENABLE_EXPERIMENTAL_FEATURES", "experimental"
-            ),
-        )
-
-        return args
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_integrals/package.py b/spack_repo/nwchemex/core/packages/nwchemex_integrals/package.py
index 295ce03..a2ca584 100644
--- a/spack_repo/nwchemex/core/packages/nwchemex_integrals/package.py
+++ b/spack_repo/nwchemex/core/packages/nwchemex_integrals/package.py
@@ -67,7 +67,16 @@ class NwchemexIntegrals(NWChemExBasePybindings):
     # pkg.depends_on("sigma+eigen", when="+sigma")
 
     # First-party
-    pkg.depends_on("nwchemex-simde")
+    pkg.depends_on(
+        "nwchemex-simde+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-simde~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
 
     # Start with CMaize sanity check locations
     sanity_check_is_dir = NWChemExBasePybindings.cmaize_sanity_check_dirs(
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_nux/package.py b/spack_repo/nwchemex/core/packages/nwchemex_nux/package.py
index bb85011..9a97ef7 100644
--- a/spack_repo/nwchemex/core/packages/nwchemex_nux/package.py
+++ b/spack_repo/nwchemex/core/packages/nwchemex_nux/package.py
@@ -52,16 +52,17 @@ class NwchemexNux(NWChemExBasePybindings):
         sha256="58cb55b4975baf3255208333fd4366293efe55b0aeaab3c269f7485f75f2061b",
     )
 
-    # TODO: Should this still be here for SimDE propagation?
-    # pkg.variant(
-    #     "sigma",
-    #     default=False,
-    #     description="Enable Sigma for uncertainty tracking",
-    #     sticky=True,
-    # )
-
     # First-party
-    pkg.depends_on("nwchemex-simde")
+    pkg.depends_on(
+        "nwchemex-simde+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-simde~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
 
     # Start with CMaize sanity check locations
     sanity_check_is_dir = NWChemExBasePybindings.cmaize_sanity_check_dirs(
@@ -71,14 +72,3 @@ class NwchemexNux(NWChemExBasePybindings):
         project.lower()
     )
     # Append more sanity checks as needed
-
-    def cmake_args(self):
-        args = super().cmake_args()
-
-        args.extend(
-            [
-                self.define_from_variant("ENABLE_SIGMA", "sigma"),
-            ]
-        )
-
-        return args
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_nwchemex/_package.py b/spack_repo/nwchemex/core/packages/nwchemex_nwchemex/_package.py
new file mode 100644
index 0000000..12e729a
--- /dev/null
+++ b/spack_repo/nwchemex/core/packages/nwchemex_nwchemex/_package.py
@@ -0,0 +1,129 @@
+# Copyright 2013-2024 Lawrence Livermore National Security, LLC and other
+# Spack Project Developers. See the top-level COPYRIGHT file for details.
+#
+# SPDX-License-Identifier: (Apache-2.0 OR MIT)
+
+# ----------------------------------------------------------------------------
+# If you submit this package back to Spack as a pull request,
+# please first remove this boilerplate and all FIXME comments.
+#
+# This is a template package file for Spack.  We've put "FIXME"
+# next to all the things you'll want to change. Once you've handled
+# them, you can save this file and test your package like this:
+#
+#     spack install nwchemex-simde
+#
+# You can edit this file again by typing:
+#
+#     spack edit nwchemex-simde
+#
+# See the Spack documentation for more information on packaging.
+# ----------------------------------------------------------------------------
+
+from spack import package as pkg
+
+from spack_repo.nwchemex.common.mixins import NWChemExBasePybindings
+
+
+class NwchemexNwchemex(NWChemExBasePybindings):
+    """Generic, helpful C++ classes used by the NWChemEx project."""
+
+    project = "NWChemEx"
+
+    homepage = f"https://github.com/NWChemEx/{project}"
+    url = f"https://github.com/NWChemEx/{project}/archive/refs/tags/v0.0.27.tar.gz"
+    git = f"https://github.com/NWChemEx/{project}.git"  # For the latest commit
+
+    # Versions are hosted under GitHub tags right now
+    list_url = f"https://github.com/NWChemEx/{project}/tags"
+    # To get older versions, uncomment 'list_depth' below and set it to a
+    # value >0 to get list_depth + 1 pages of versions.
+    # WARNING: This increases the number of links that the search spider will
+    # follow, meaning even 'list_depth = 1' may increase the search time
+    # significantly!
+    # list_depth = 1
+
+    pkg.maintainers("ryanmrichard", "jwaldrop107", "zachcran")
+    pkg.license("Apache-2.0", checked_by="zachcran")
+
+    # Versions from git tags
+    pkg.version(
+        "0.0.27",
+        sha256="1bd22792ca0fbe74f95b2065f2f2d674f2c62d186a340150e8ed1e0f27c2d334",
+    )
+
+    # TODO: Should this still be here for SimDE propagation?
+    # pkg.variant(
+    #     "sigma",
+    #     default=False,
+    #     description="Enable Sigma for uncertainty tracking",
+    #     sticky=True,
+    # )
+    # TODO: Handle this turned on
+    pkg.variant(
+        "tamm",
+        default=False,
+        description="Build modules that rely on TAMM/Exachem",
+    )
+    pkg.variant(
+        "full-chemcache",
+        default=False,
+        description="If ChemCache isn't found, build the full version",
+        sticky=False,
+    )
+
+    # First-party
+    pkg.depends_on(
+        "nwchemex-friendzone+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-scf+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-scf~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
+    pkg.depends_on(
+        "nwchemex-nux+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-nux~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
+    pkg.depends_on(
+        "nwchemex-chemcache+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-chemcache~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
+    pkg.depends_on(
+        "nwchemex-integrals+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-integrals~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
+
+    # Start with CMaize sanity check locations
+    # sanity_check_is_dir = NWChemExBasePybindings.cmaize_sanity_check_dirs(
+    #     project.lower()
+    # )
+    # sanity_check_is_file = NWChemExBasePybindings.cmaize_sanity_check_files(
+    #     project.lower()
+    # )
+    # Append more sanity checks as needed
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_nwchemex/package.py b/spack_repo/nwchemex/core/packages/nwchemex_nwchemex/package.py
index b4e2de4..d8afa69 100644
--- a/spack_repo/nwchemex/core/packages/nwchemex_nwchemex/package.py
+++ b/spack_repo/nwchemex/core/packages/nwchemex_nwchemex/package.py
@@ -22,10 +22,10 @@
 
 from spack import package as pkg
 
-from spack_repo.nwchemex.common.mixins import NWChemExBasePybindings
+from spack_repo.nwchemex.common.mixins import NWChemExBasePython
 
 
-class NwchemexNwchemex(NWChemExBasePybindings):
+class NwchemexNwchemex(NWChemExBasePython):
     """Generic, helpful C++ classes used by the NWChemEx project."""
 
     project = "NWChemEx"
@@ -47,61 +47,47 @@ class NwchemexNwchemex(NWChemExBasePybindings):
     pkg.license("Apache-2.0", checked_by="zachcran")
 
     # Versions from git tags
+    pkg.version("python_package", branch="python_package")
     pkg.version(
         "0.0.27",
         sha256="1bd22792ca0fbe74f95b2065f2f2d674f2c62d186a340150e8ed1e0f27c2d334",
     )
 
-    # TODO: Should this still be here for SimDE propagation?
-    # pkg.variant(
-    #     "sigma",
-    #     default=False,
-    #     description="Enable Sigma for uncertainty tracking",
-    #     sticky=True,
-    # )
-    # TODO: Handle this turned on
-    pkg.variant(
-        "tamm",
-        default=False,
-        description="Build modules that rely on TAMM/Exachem",
-    )
-    pkg.variant(
-        "full-chemcache",
-        default=False,
-        description="If ChemCache isn't found, build the full version",
-        sticky=False,
-    )
-
-    # TODO: Create this package
-    # pkg.depends_on("gauxc")
-    pkg.depends_on("eigen")
-    pkg.depends_on("libint", when="+tamm")
-    # pkg.depends_on("tamm", when="+tamm")
-    # pkg.depends_on("exachem", when="+tamm")
+    # TODO: Many of these may be able to be switched to ("build", "run")
+    # instead of ("build", "link", "run")
+    pkg.depends_on("python@3.10:", type=("build", "run"))
+    pkg.depends_on("py-setuptools", type="build")
 
     # First-party
-    pkg.depends_on("nwchemex-friendzone")
-    pkg.depends_on("nwchemex-scf")
-    pkg.depends_on("nwchemex-nux")
-    pkg.depends_on("nwchemex-chemcache")
-    pkg.depends_on("nwchemex-integrals")
-
-    # Start with CMaize sanity check locations
-    sanity_check_is_dir = NWChemExBasePybindings.cmaize_sanity_check_dirs(
-        project.lower()
+    # TODO: Figure out how to ensure that the correct value for the "friends"
+    # variant can be propagated, or switch each friend to a separate variant
+    pkg.depends_on(
+        "nwchemex-friendzone",
+        type=("build", "link", "run"),
     )
-    sanity_check_is_file = NWChemExBasePybindings.cmaize_sanity_check_files(
-        project.lower()
+    pkg.depends_on(
+        "nwchemex-scf+python",
+        type=("build", "link", "run"),
+    )
+    pkg.depends_on(
+        "nwchemex-nux+python",
+        type=("build", "link", "run"),
+    )
+    pkg.depends_on(
+        "nwchemex-chemcache+python",
+        type=("build", "link", "run"),
+    )
+    pkg.depends_on(
+        "nwchemex-integrals+python",
+        type=("build", "link", "run"),
     )
-    # Append more sanity checks as needed
-
-    def cmake_args(self):
-        args = super().cmake_args()
-
-        args.extend(
-            self.define_from_variant(
-                "ENABLE_EXPERIMENTAL_FEATURES", "experimental"
-            ),
-        )
 
-        return args
+    # TODO: Add sanity checks
+    # Start with CMaize sanity check locations
+    # sanity_check_is_dir = NWChemExBasePybindings.cmaize_sanity_check_dirs(
+    #     project.lower()
+    # )
+    # sanity_check_is_file = NWChemExBasePybindings.cmaize_sanity_check_files(
+    #     project.lower()
+    # )
+    # Append more sanity checks as needed
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_parallelzone/package.py b/spack_repo/nwchemex/core/packages/nwchemex_parallelzone/package.py
index a4a55c1..6111d81 100644
--- a/spack_repo/nwchemex/core/packages/nwchemex_parallelzone/package.py
+++ b/spack_repo/nwchemex/core/packages/nwchemex_parallelzone/package.py
@@ -85,4 +85,15 @@ class NwchemexParallelzone(NWChemExBasePybindings):
     sanity_check_is_file = NWChemExBasePybindings.cmaize_sanity_check_files(
         project.lower()
     )
+
     # Append more sanity checks as needed
+    def cmake_args(self):
+        args = super().cmake_args()
+
+        args.extend(
+            [
+                self.define_from_variant("BUILD_PAPI_BINDINGS ", "papi"),
+            ]
+        )
+
+        return args
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_pluginplay/package.py b/spack_repo/nwchemex/core/packages/nwchemex_pluginplay/package.py
index f8c5006..2fcd7ff 100644
--- a/spack_repo/nwchemex/core/packages/nwchemex_pluginplay/package.py
+++ b/spack_repo/nwchemex/core/packages/nwchemex_pluginplay/package.py
@@ -21,6 +21,7 @@
 # ----------------------------------------------------------------------------
 
 from spack import package as pkg
+
 from spack_repo.nwchemex.common.mixins import NWChemExBasePybindings
 
 
@@ -63,7 +64,16 @@ class NwchemexPluginplay(NWChemExBasePybindings):
     pkg.depends_on("rocksdb", when="+rocksdb")
     # First-party
     pkg.depends_on("nwchemex-utilities")
-    pkg.depends_on("nwchemex-parallelzone")
+    pkg.depends_on(
+        "nwchemex-parallelzone+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-parallelzone~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
 
     # Start with CMaize sanity check locations
     sanity_check_is_dir = NWChemExBasePybindings.cmaize_sanity_check_dirs(
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_scf/package.py b/spack_repo/nwchemex/core/packages/nwchemex_scf/package.py
index ce7b1b9..1194533 100644
--- a/spack_repo/nwchemex/core/packages/nwchemex_scf/package.py
+++ b/spack_repo/nwchemex/core/packages/nwchemex_scf/package.py
@@ -51,46 +51,28 @@ class NwchemexScf(NWChemExBasePybindings):
         sha256="b175c15e8c814cd288817c970f4e049c7eab248975ff7c891d8927d7555d0cd8",
     )
 
-    pkg.variant(
-        "sigma",
-        default=False,
-        description="Enable Sigma for uncertainty tracking",
-        sticky=True,
-    )
-    # TODO: Handle this turned on
-    pkg.variant(
-        "tamm",
-        default=False,
-        description="Build modules that rely on TAMM/Exachem",
-    )
-    pkg.variant(
-        "experimental",
-        default=False,
-        description="Enable experimental features",
-        sticky=False,
-    )
-
     # For building GauXC, I think
     pkg.depends_on("c", type="build")
 
     # TODO: Create this package
     # pkg.depends_on("gauxc")
     pkg.depends_on("eigen")
-    # The "tune" variant is not available prior to v2.6
-    # TODO: A value of "tune=none" or any of the molgw-* options likely break
-    # the unit tests, but I don't know how to add them as conflicts yet.
-    pkg.depends_on("libint@2.6:", when="+tamm")
     pkg.depends_on("mpi")
     pkg.depends_on("py-numpy")
-    # pkg.depends_on("tamm", when="+tamm")
-    # pkg.depends_on("exachem", when="+tamm")
-
-    # Although we have a variant, technically it is not a direct dependency
-    # of this package
-    # pkg.depends_on("sigma+eigen", when="+sigma")
+    # Uncomment when GauXC/Libxc interactions are sorted out
+    # pkg.depends_on("libxc")
 
     # First-party
-    pkg.depends_on("nwchemex-simde")
+    pkg.depends_on(
+        "nwchemex-simde+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-simde~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
 
     # Start with CMaize sanity check locations
     sanity_check_is_dir = NWChemExBasePybindings.cmaize_sanity_check_dirs(
@@ -100,17 +82,3 @@ class NwchemexScf(NWChemExBasePybindings):
         project.lower()
     )
     # Append more sanity checks as needed
-
-    def cmake_args(self):
-        args = super().cmake_args()
-
-        args.extend(
-            [
-                self.define_from_variant(
-                    "ENABLE_EXPERIMENTAL_FEATURES", "experimental"
-                ),
-                self.define_from_variant("ENABLE_SIGMA", "sigma"),
-            ]
-        )
-
-        return args
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_simde/package.py b/spack_repo/nwchemex/core/packages/nwchemex_simde/package.py
index 809253b..6abe88f 100644
--- a/spack_repo/nwchemex/core/packages/nwchemex_simde/package.py
+++ b/spack_repo/nwchemex/core/packages/nwchemex_simde/package.py
@@ -59,8 +59,26 @@ class NwchemexSimde(NWChemExBasePybindings):
     )
 
     # First-party
-    pkg.depends_on("nwchemex-chemist")
-    pkg.depends_on("nwchemex-pluginplay")
+    pkg.depends_on(
+        "nwchemex-chemist+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-chemist~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
+    pkg.depends_on(
+        "nwchemex-pluginplay+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "nwchemex-pluginplay~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
 
     pkg.depends_on("sigma+eigen", when="+sigma")
 
diff --git a/spack_repo/nwchemex/core/packages/nwchemex_tensorwrapper/package.py b/spack_repo/nwchemex/core/packages/nwchemex_tensorwrapper/package.py
index 43c8bd4..675bd6c 100644
--- a/spack_repo/nwchemex/core/packages/nwchemex_tensorwrapper/package.py
+++ b/spack_repo/nwchemex/core/packages/nwchemex_tensorwrapper/package.py
@@ -60,11 +60,26 @@ class NwchemexTensorwrapper(NWChemExBasePybindings):
 
     # Runtime dependencies
     pkg.depends_on("boost")
-    pkg.depends_on("eigen")
+    pkg.depends_on("eigen", type=("build", "link", "run"))
+    pkg.depends_on("py-numpy", when="+python", type=("build", "run"))
 
     # First-party
     pkg.depends_on("nwchemex-utilities")
-    pkg.depends_on("nwchemex-parallelzone")
+    pkg.depends_on(
+        "nwchemex-parallelzone~python",
+        type=("build", "link", "run"),
+        when="~python",
+    )
+    pkg.depends_on(
+        "nwchemex-parallelzone+python",
+        type=("build", "link", "run"),
+        when="+python",
+    )
+    pkg.depends_on(
+        "py-numpy",
+        type=("build", "link", "run"),
+        when="+python",
+    )
 
     pkg.depends_on("sigma+eigen", when="+sigma")
 
diff --git a/spack_repo/nwchemex/core/packages/py_qcelemental/package.py b/spack_repo/nwchemex/core/packages/py_qcelemental/package.py
new file mode 100644
index 0000000..963d564
--- /dev/null
+++ b/spack_repo/nwchemex/core/packages/py_qcelemental/package.py
@@ -0,0 +1,92 @@
+# Copyright Spack Project Developers. See COPYRIGHT file for details.
+#
+# SPDX-License-Identifier: (Apache-2.0 OR MIT)
+
+# ----------------------------------------------------------------------------
+# If you submit this package back to Spack as a pull request,
+# please first remove this boilerplate and all FIXME comments.
+#
+# This is a template package file for Spack.  We've put "FIXME"
+# next to all the things you'll want to change. Once you've handled
+# them, you can save this file and test your package like this:
+#
+#     spack install py-qcelemental
+#
+# You can edit this file again by typing:
+#
+#     spack edit py-qcelemental
+#
+# See the Spack documentation for more information on packaging.
+# ----------------------------------------------------------------------------
+
+from spack_repo.builtin.build_systems.python import PythonPackage
+
+from spack import package as pkg
+
+
+class PyQcelemental(PythonPackage):
+    """FIXME: Put a proper description of your package here."""
+
+    homepage = "https://github.com/MolSSI/QCElemental"
+    url = "https://github.com/MolSSI/QCElemental/archive/refs/tags/v0.29.0.tar.gz"
+    git = "https://github.com/MolSSI/QCElemental.git"
+    # pypi = "qcelemental/qcelemental-0.29.0.tar.gz"
+
+    pkg.maintainers("ryanmrichard", "jwaldrop107", "zachcran")
+
+    pkg.license("BSD-3-Clause")
+
+    pkg.version(
+        "0.29.0",
+        sha256="3571b9bc6c67faba8ea9d988948fd8efc593bf3b5d533486f84ee2e423d60c1e",
+    )
+    pkg.version(
+        "0.28.0",
+        sha256="59f2104095b2d5bd78b02149c50c06fa884cde9fc2f49272edd0ec2e7f5fdd3d",
+    )
+    pkg.version(
+        "0.27.1",
+        sha256="10686a022e7e85259d6ee1730c29cedff1b67c8a21d753b336fb4c42529922b1",
+    )
+    pkg.version(
+        "0.27.0",
+        sha256="bf9ce6d6e134e905a5818c5907a3b8fa9fd8754eeb6b7519bd58c1a6a8177f1a",
+    )
+    pkg.version(
+        "0.26.0",
+        sha256="fe198b92298c2a922b5e780757c055a522b31e46178851594185924df82bc00a",
+    )
+    pkg.version(
+        "0.25.1",
+        sha256="87decd18ff6fffbbded4c77fe974c332a12573b9075247f461d57ec88301ac8b",
+    )
+    pkg.version(
+        "0.25.0",
+        sha256="aad969fb10ac803a659f400a8ffd452f8bfa98409c092a136761dc99eb8374a8",
+    )
+    pkg.version(
+        "0.24.0",
+        sha256="154367a7afa0a532325972caa16fd55b27c711fc4520a371eb9db56f4c2c62d1",
+    )
+    pkg.version(
+        "0.23.0",
+        sha256="a6c9b77e66241b0862bcad8507aa94c40d5f54d299f46484363e3413caa93185",
+    )
+    pkg.version(
+        "0.22.0",
+        sha256="e8d5e2cb00e5d8cd996157150e7270b304760c8a2bb569c68ad8ce279d5702d0",
+    )
+
+    pkg.depends_on("python@3.7:", type=("build", "run"))
+
+    pkg.depends_on("py-poetry-core", type="build")
+
+    pkg.depends_on("py-numpy@1.26:", type=("build", "run"))
+    pkg.depends_on("py-packaging@24.1:", type=("build", "run"))
+    pkg.depends_on("py-pint@0.24:", type=("build", "run"))
+    pkg.depends_on("py-pydantic@1.8.2:", type=("build", "run"))
+    pkg.depends_on("py-importlib-metadata@4.8:", type=("build", "run"))
+    pkg.depends_on("py-networkx~default", type=("build", "run"))
+    pkg.depends_on("py-scipy@1.9.0:", type=("build", "run"))
+    pkg.depends_on("py-setuptools@68.0.0:", type=("build", "run"))
+    pkg.depends_on("py-pytest@7.2.2:", type=("build", "run"))
diff --git a/spack_repo/nwchemex/core/packages/py_qcengine/package.py b/spack_repo/nwchemex/core/packages/py_qcengine/package.py
new file mode 100644
index 0000000..e6b92b6
--- /dev/null
+++ b/spack_repo/nwchemex/core/packages/py_qcengine/package.py
@@ -0,0 +1,90 @@
+# Copyright Spack Project Developers. See COPYRIGHT file for details.
+#
+# SPDX-License-Identifier: (Apache-2.0 OR MIT)
+
+# ----------------------------------------------------------------------------
+# If you submit this package back to Spack as a pull request,
+# please first remove this boilerplate and all FIXME comments.
+#
+# This is a template package file for Spack.  We've put "FIXME"
+# next to all the things you'll want to change. Once you've handled
+# them, you can save this file and test your package like this:
+#
+#     spack install py-qcengine
+#
+# You can edit this file again by typing:
+#
+#     spack edit py-qcengine
+#
+# See the Spack documentation for more information on packaging.
+# ----------------------------------------------------------------------------
+
+from spack_repo.builtin.build_systems.python import PythonPackage
+
+from spack import package as pkg
+
+
+class PyQcengine(PythonPackage):
+    """QCEngine provides a wrapper to ingest and produce QCSchema for a variety
+    of quantum chemistry programs."""
+
+    homepage = "https://github.com/MolSSI/QCEngine"
+    url = "https://github.com/MolSSI/QCEngine/archive/refs/tags/v0.29.0.tar.gz"
+    git = "https://github.com/MolSSI/QCEngine.git"
+    # pypi = "qcengine/qcengine-0.33.0.tar.gz"
+
+    pkg.maintainers("ryanmrichard", "jwaldrop107", "zachcran")
+
+    pkg.license("BSD-3-Clause")
+
+    pkg.version(
+        "0.33.0",
+        sha256="7d9317355294b2118b9e959e57394eb3f2205db004d9ebe7441cd5026a7fc6c4",
+    )
+    pkg.version(
+        "0.32.0",
+        sha256="666ae2eeec6758904548ac72199964c2141a1fcd2f14fed5dbe8bc324e43e4ac",
+    )
+    pkg.version(
+        "0.31.0",
+        sha256="1d220c32efa813191a95a5c6a7aa8035551e4126230b60dccea4af236eeff810",
+    )
+    pkg.version(
+        "0.30.0",
+        sha256="896c690fa82a5f65b6d702775ac61606dc54050f8642f0c04b6497c5f9bdca62",
+    )
+    pkg.version(
+        "0.29.0",
+        sha256="a790f733d9132675636216011286415872ce815e6a4e7f7029ccde8c90293bfc",
+    )
+    pkg.version(
+        "0.28.1",
+        sha256="11555cfc475fe6d048da6335fc1e2150a6c5f8082a415c45fe596e4fc96588ee",
+    )
+    pkg.version(
+        "0.28.0",
+        sha256="c4b27a7a2f06e02e0ddfabf9b9b95adcc4f92acdd9a55678ae603d79a8464e60",
+    )
+    pkg.version(
+        "0.27.0",
+        sha256="d339976c880c79cfe2da7cdb8458895a97322ca2abd134734b0b15031f5e3eeb",
+    )
+    pkg.version(
+        "0.26.0",
+        sha256="0659fc6e92d0b8bd2252e4d0290543fdbf6fd5361943b4a43d429fe3074ab2dc",
+    )
+    pkg.version(
+        "0.25.0",
+        sha256="2b651ed588c606cb9a734d4cfe04f8dfdee5ce7ccc64885c38f1a4e7798dadea",
+    )
+
+    pkg.depends_on("python@3.7:", type=("build", "run"))
+
+    pkg.depends_on("py-setuptools", type="build")
+
+    pkg.depends_on("py-pyyaml", type=("build", "run"))
+    pkg.depends_on("py-py-cpuinfo", type=("build", "run"))
+    pkg.depends_on("py-psutil", type=("build", "run"))
+    pkg.depends_on("py-pydantic@1.8.2:", type=("build", "run"))
+    pkg.depends_on("py-packaging", type=("build", "run"))
+    pkg.depends_on("py-qcelemental", type=("build", "run"))