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To avoid n^2 distance matrices, we could compute tanimoto distances on the fly when running Butina. However, butina can be run on generic data, so any use case we want to support has to be done on a case-by-case basis.
To avoid n^2 distance matrices, we could compute tanimoto distances on the fly when running Butina. However, butina can be run on generic data, so any use case we want to support has to be done on a case-by-case basis.