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README.md

scvi-tools

Deep generative models for single-cell omics — probabilistic batch correction, transfer learning, differential expression with uncertainty, and multi-modal integration.

What it does

Wraps the scvi-tools library for advanced single-cell analysis: scVI for batch correction and latent space modeling, TOTALVI for CITE-seq (RNA + protein), MultiVI for multiome (RNA + ATAC), scANVI for semi-supervised cell type annotation, and differential expression with posterior uncertainty quantification.

Setup

cd scvi-tools
python3 -m venv .venv && source .venv/bin/activate && pip install scvi-tools -q

Environment variables

None.

Usage

python3 scripts/demo.py --format summary

Dependencies

  • scvi-tools

Tested with

  • Direct script run: pass (--help)
  • Agno agent (Claude Haiku 4.5): pass

Agno agent verdict

Agent loaded the skill and described scVI, TOTALVI, MultiVI, and scANVI models with their respective use cases.

Fix notes

  • Cleaned __pycache__/, 1 ruff lint fix