diff --git a/src/main/java/binnie/core/machines/power/IProcess.java b/src/main/java/binnie/core/machines/power/IProcess.java
index ba70a6ada..fc2b996bd 100644
--- a/src/main/java/binnie/core/machines/power/IProcess.java
+++ b/src/main/java/binnie/core/machines/power/IProcess.java
@@ -9,4 +9,11 @@ public interface IProcess extends IErrorStateSource {
     boolean isInProgress();
 
     ProcessInfo getInfo();
+
+    /***
+     * Returns true if the current target got worked on at least once.
+     */
+    default boolean workedOnTarget() {
+        return false;
+    }
 }
diff --git a/src/main/java/binnie/genetics/machine/splicer/SplicerComponentLogic.java b/src/main/java/binnie/genetics/machine/splicer/SplicerComponentLogic.java
index 5d8f1055b..6fea9bf6f 100644
--- a/src/main/java/binnie/genetics/machine/splicer/SplicerComponentLogic.java
+++ b/src/main/java/binnie/genetics/machine/splicer/SplicerComponentLogic.java
@@ -19,6 +19,10 @@
 
 public class SplicerComponentLogic extends ComponentProcessSetCost implements IProcess {
 
+    // Needed to keep stack. If user takes out target slot and it gets automatically refilled, this happens in the same
+    // tick
+    private ItemStack workedOnStack = null;
+
     public int nOfGenes;
 
     public SplicerComponentLogic(Machine machine) {
@@ -50,6 +54,11 @@ public int getProcessEnergy() {
     public void onInventoryUpdate() {
         super.onInventoryUpdate();
         nOfGenes = getGenesToUse();
+        ItemStack newTarget = getUtil().getStack(Splicer.SLOT_TARGET);
+
+        if (newTarget == null || !ItemStack.areItemStacksEqual(workedOnStack, newTarget)) {
+            workedOnStack = null;
+        }
     }
 
     protected int getGenesToUse() {
@@ -190,5 +199,31 @@ protected void onFinishTask() {
             Splicer.setGene(gene, target, 1);
         }
         getUtil().damageItem(Splicer.SLOT_SERUM_VIAL, 1);
+        workedOnStack = getUtil().getStack(Splicer.SLOT_TARGET).copy();
+    }
+
+    @Override
+    public boolean workedOnTarget() {
+        return ItemStack.areItemStacksEqual(workedOnStack, getUtil().getStack(Splicer.SLOT_TARGET));
+    }
+
+    @Override
+    public void readFromNBT(NBTTagCompound nbt) {
+        super.readFromNBT(nbt);
+        NBTTagCompound tagWorkedOnStack = (NBTTagCompound) nbt.getTag("workedOnStack");
+        if (tagWorkedOnStack != null) {
+            workedOnStack = ItemStack.loadItemStackFromNBT(tagWorkedOnStack);
+        }
+    }
+
+    @Override
+    public void writeToNBT(NBTTagCompound nbt) {
+        super.writeToNBT(nbt);
+        if (workedOnStack != null) {
+            NBTTagCompound tagWorkedOnStack = new NBTTagCompound();
+            workedOnStack.writeToNBT(tagWorkedOnStack);
+            // Need to save, in case inventory is full it might need to get moved out way later.
+            nbt.setTag("workedOnStack", tagWorkedOnStack);
+        }
     }
 }
diff --git a/src/main/java/binnie/genetics/machine/splicer/SplicerPackage.java b/src/main/java/binnie/genetics/machine/splicer/SplicerPackage.java
index 174bd616f..44335eb2c 100644
--- a/src/main/java/binnie/genetics/machine/splicer/SplicerPackage.java
+++ b/src/main/java/binnie/genetics/machine/splicer/SplicerPackage.java
@@ -3,6 +3,7 @@
 import net.minecraft.item.ItemStack;
 
 import binnie.core.craftgui.minecraft.IMachineInformation;
+import binnie.core.machines.IMachine;
 import binnie.core.machines.Machine;
 import binnie.core.machines.inventory.ComponentInventorySlots;
 import binnie.core.machines.inventory.ComponentInventoryTransfer;
@@ -79,8 +80,20 @@ public boolean fufilled(ItemStack stack) {
 
             @Override
             public boolean fufilled(ItemStack stack) {
-                return stack != null && transfer.getMachine().getMachineUtil().getStack(Splicer.SLOT_SERUM_VIAL) != null
-                        && transfer.getMachine().getInterface(SplicerComponentLogic.class).isValidSerum() != null;
+                if (stack == null) {
+                    return false;
+                }
+                IMachine machine = transfer.getMachine();
+                boolean hasSerum = machine.getMachineUtil().getStack(Splicer.SLOT_SERUM_VIAL) != null;
+
+                if (hasSerum) {
+                    // Move item if it can't be processed anymore with current serum.
+                    boolean validSerum = machine.getInterface(SplicerComponentLogic.class).isValidSerum() == null;
+                    return !validSerum;
+                } else {
+                    // Move item if there is no serum and item got processed already
+                    return machine.getMachineUtil().getProcess().workedOnTarget();
+                }
             }
         });