diff --git a/participants/thyroid-cancer.md b/participants/thyroid-cancer.md new file mode 100644 index 0000000..aefd796 --- /dev/null +++ b/participants/thyroid-cancer.md @@ -0,0 +1,38 @@ +--- +title: Thyroid Cancer Research Group, The University of Sydney +description: +toc: false +type: ABLeS Participant +--- + +## Project title + +Applying single cell RNA sequencing to understand the immune landscape of thyroid cancer, with the goal of identifying therapeutic targets and biomarkers. + +## Collaborators and funding + +- Thyroid Cancer Research Group, Faculty of Medicine and Health, University of Sydney +- Kolling Institute of Medical Research +- Sydney Informatics Hub, University of Sydney + +## Contact(s) + +- Dr Martyn Bullock +- Dr Georgie Samaha +- Mr Frederick Jaya + +## Project description and aims + +Understanding the immune composition of thyroid tumours is critical for identifying novel therapeutic targets and predictive biomarkers. Leveraging single-cell RNA sequencing, this study will profile the tumour immune microenvironment at high resolution, enabling the discovery of cell-type-specific expression patterns and pathway dysregulation. + +This project will be implemented on NCI's Gadi HPC, leveraging the open source [nf-core/scrnaseq](https://nf-co.re/scrnaseq) pipeline, and will produce public interactive notebooks for quality control, cell type annotation, differential expression, and biomarker discovery. + +## How is ABLeS supporting this work? + +This work is supported through the production bioinformatics scheme provided by ABLeS. The support includes and 10 KSUs per quarter. + +## Expected outputs enabled by participation in ABLeS + +A public scalable computational workflow and analytical notebooks for single-cell RNA sequencing in cancer cohorts that can be deployed on NCI Gadi. + +